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Actical (Calcitriol)
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Actical

Actical is a hormonally-active, synthetic vitamin D analog prescribed to treat hypocalcemia, osteoporosis, and the prevention of corticosteroid-induced osteoporosis. Systemic Actical is FDA indicated to control hypocalcemia in patients on chronic renal dialysis, secondary hyperparathyroidism in those with chronic kidney disease not yet on dialysis, and hypocalcemia in patients with hypoparathyroidism and pseudohypoparathyroidism.

Other names for this medication:
Actical, Alcee, Alfacalcirol, Alfarich, Aristrol, Calbec, Calbory, Calbovic, Calcikind, Calcirol, Calcit, Calday, Calfa, Calsonic, Caltive, Caltop, Calvical, Calzem, Denscal, Estovon, Fovit, Koncal, Kurecal, Laretol, Lctrol, Minroset, Netxod, Nutribone, Politrol, Qpcal, Rical, Rockbon, Roical, Rolsical, Statbone, Tobalt, Trolec

Similar Products:
Zyloprim, Lunesta, Omnicef, Cardura, Aricept, Zantac

Also known as: Calcitriol

Description

Generic Actical is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Actical are intestine and bone. Generic Actical receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Actical may also act on the kidney and the parathyroid glands. Generic Actical is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Actical has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Actical, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Actical in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Actical produces other independent beneficial effects. Actical is also known as Calcitriol. Generic Actical treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Actical is Calcitriol. Brand name of Generic Actical is Actical.

Dosage

Generic Actical is available in capsules (0.25 mcg) and liquid form. Capsules must be swallowed whole. Do not crush or chew them. If you are prescribed the liquid form, use as directed. Follow dosing instructions closely. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. If you want to achieve most effective results do not stop taking Generic Actical suddenly.

Overdose

If you overdose Generic Actical and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Side effects

The most common side effects associated with Actical are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Generic Actical if you are allergic to Generic Actical components. Do not take Generic Actical if you are pregnant, planning to become pregnant, or are breast-feeding. It is not known if this medication appears in breast milk. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Be careful with Generic Actical if you have heart disease, kidney disease or kidney stones, coronary artery disease (hardening of the arteries). Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. It can be dangerous to stop Generic Actical taking suddenly.

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Histological study of the changes provoked locally by histamine and 5-hydroxytryptamine in connective tissue newly formed in Ivalon sponge. Influence of local antiseptics on regeneration of corneal epithelium of rabbits. Blood samples were drawn into four different tubes from three patient populations-apparently healthy patients, patients on oral anticoagulant therapy with vitamin K antagonists (OAT-vka) and patients being treated with unfractioned heparin (UFH). Nevertheless, the medical supply of these patients is quite heterogenous and consistent standards do not exist. A case is described of an elderly woman who presented with headaches, hypopituitarism, and visual disturbances and was found to have idiopathic granulomatous hypophysitis, a rare lesion of the pituitary gland. Three hundred eligible neonates were randomly allocated to three parallel groups. Differentiated vascular adjustments reflexly induced by changes in the carotid baro- and chemoreceptor activity and by asphyxia. The combination of well designed validation studies which demonstrate consistent product quality as a function of cell age, and rigorous quality control of every product lot by sensitive protein analytical methods provide the necessary assurance that product structure is not being altered through mechanisms of mutation and selection. Likewise, infections in immunosuppressed hosts, especially those who are neutropenic, are often thought to require microbicidal therapy.

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Exploration of synergistic and redundant information sharing in static and dynamical Gaussian systems. Sry-negative XX sex reversal in a family of Norwegian Elkhounds. One and one half ventricle repair for pure pulmonary atresia--a case report. Variables for the study included both hospital and patient characteristics. Human brain anatomy is extraordinarily complex, and yet, its origin is a simple tubular structure. The interface tissue between the LA and rhabdosphincter area in males contained abundant irregularly arrayed elastic fibers and smooth muscles. Small interference RNA (siRNA) was constructed to knock down GATA3 expression in Hut-78 cells to investigate the possible role of GATA3-NFAT1 complex in IL-13 transcription. Here we introduce a new pulse sequence for resonance assignment that halves the number of data sets required for sequential linking by directly correlating sequential amide resonances in a single diagonal-free spectrum. Association of colorectal cancer susceptibility variants with esophageal cancer in a Chinese population. This is the first prospective study comparing the efficacy of several new topical anesthetic agents.

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Influences of percutaneous administration of estradiol and progesterone on human breast epithelial cell cycle in vivo. The Diabetes Committee of the American Orthopaedic Foot and Ankle Society. Increased basal levels of hsCRP also correlated with severity of stroke and extent of infarct reflected by S100B levels in sera, but did not correlate with post-stroke infections. The role of the Leuconostoc citrovorum factor (LCF) in cell division and the mode of action of folic-acid antagonists on normal and leukaemic cells. Syndromes of shock and adaptation to renal physiopathology in course of the hypertensive phase observed in therapeutic hypotension. A randomized double blind placebo controlled trial for 6 months followed by an open trial of GH treatment for 12 months. Thus, cGMP inhibition of U-46619 actions is expressed at steps distal to TX receptor binding and may involve effects at and proximal to activation of PKC. Left colonic necrosis was seen in two patients while incisional hernia was observed in two patients.

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Identification of a high affinity TAG-72 binding peptide by phage display selection. An important aim of proteome analysis is to study the level of the expressed genes and their response to environmental changes. Subrepeat II consists of nine successive repeat units with a consensus sequence length of 142 bp. A novel neural-network model for deriving standard 12-lead ECGs from serial three-lead ECGs: application to self-care. Increased risk of adenomas in individuals with a family history of colorectal cancer: results of a meta-analysis. These techniques are growing rapidly in popularity, and a great deal of recent research, reviewed in this paper, has examined their ability to restore normal mechanical function to fractured vertebrae. Psychiatric challenges in the first 6 years after traumatic brain injury: cross-sequential analyses of Axis I disorders.

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Vascular injury at the microvascular and macrovascular levels plays a crucial role in the patient with diabetes mellitus. Meningeal relapse in a patient with acute promyelocytic leukemia: a case report and review of the literature. Acute toxicity test of CuO nanoparticles using human mesenchymal stem cells. Ineffectiveness of penicillin in some cases of bacterial endocarditis. Previous studies with FGF-2 identified a low affinity receptor binding site that is located within a loop connecting its 9th and 10th beta-strands.

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