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Adalate (Nifedipine)

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Adalate is a calcium-channel blocker. It affects the amount of calcium found in your heart and muscle cells. This relaxes your blood vessels, which can reduce the amount of work the heart has to do. This medicine is used to treat chest pain caused by angina.

Other names for this medication:
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Also known as: Nifedipine


Nifedipine is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Nifedipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, nifedipine relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain nifedipine. It may not be specific to Adalate PA 10. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended release tablet whole. Do not break, crush, or chew it. It is best to take this tablet on an empty stomach.

If you are taking the extended-release tablets, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of chest pain or high blood pressure: For oral dosage form (capsules): Adults—At first, 10 milligrams (mg) three times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 30 or 60 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 90 mg once a day. Children—Use and dose must be determined by your doctor.


If you overdose Adalate and you don't feel good you should visit your doctor or health care provider immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Nifedipine dosage information

Side effects

The most common side effects associated with Adalate are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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Animal studies show that IL-1 blockade is effective in limiting atherosclerosis and atherothrombosis and improving outcomes in acute myocardial infarction and ischemic stroke. HOMOLOGOUS INHIBITION, TOXICITY, AND MULTIPLICITY REACTIVATION WITH ULTRAVIOLET-IRRADIATED VACCINIA VIRUS. Genes of unknown function made up the largest category of the differentially expressed genes, followed by transcription regulation-related genes. THE TREATMENT OF CHRONIC RENAL FAILURE WITH LAVAGE OF THE SEPARATED INTESTINAL LOOP. The rosetting response-appears in this model to be a response to the acute phase of infection. To promote widespread adoption and use, technical assistance to support the implementation and management of interventions, evidence-based or best practice models that highlight successful implementation strategies in care delivery, and the introduction of new payment or reimbursement policies will be essential. Transcriptional modulator ZBED6 affects cell cycle and growth of human colorectal cancer cells. We conclude that a team approach between the clinician who performs the ultrasound and the reporting cytopathologist improves Bethesda reporting, its predictive value, and thus potentially avoiding unnecessary thyroidectomies in benign thyroid nodules and hemithyroidectomies in thyroid cancers. No association was found between HT and follicular, medullary, or anaplastic thyroid cancer.

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PLASMA SODIUM, CALCIUM AND POTASSIUM LEVELS IN RABBITS DURING EXPERIMENTAL ACUTE LEAD POISONING. By application of these principles, one can accurately quantify modifications undertaken to treat diseases, for example, the size of a patch that augments a vessel and the angle of an anastomosis to allow a certain flow. We can use the phantom to design any type of waveform (e.g., brain activity or systemic fluctuation) of absorption change, which can then be reproducibly measured. Clindamycin administered IV until the patient is afebrile for three consecutive days and then orally for approximately four weeks is an alternative to nafcillin/methicillin in the therapy of S aureus osteomyelitis in children. Use of multivalent metal ions to define its characteristics and role in exocytosis. In children, the co-administered volume increases with age because of a gradual switch from liquids to solid dosage forms. Human macrophages synthesize and secrete a major 95,000-dalton gelatin-binding protein distinct from fibronectin. The preparation and properties of ribonucleic acids from rat liver. Immunologically 4 different groups of gamma-crystallins (gamma 1a-1d-crystallin) could be detected. As we increasingly rely on data to understand our world, and as problems require global solutions, we need to effectively communicate that data to help people make informed decisions.

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The pregnancy-related alterations in MS, including the effect of pregnancy on disease activity, long-term disability accumulation, and prevalence will be reviewed, as well as the hormonal and immunological mechanisms potentially underlying these changes. The morphologic changes were studied in the parenchymal and digestive organs of a total of 39 calves with gastroenteritis from which pathogenic Escherichia coli organisms were isolated. Social factors in the etiology of multiple outcomes: the case of blood pressure and alcohol consumption patterns. We localized the adult-like immunoreactivity in all efferent fibres and synapses of the outer hair cells along the entire cochlear duct. This approach gives direct physical insight into the absorption mechanism in such structures, which can be used to enhance the absorption. Serial sections of longissimus dorsi and rectus femoris muscles from 15 Yorkshire breed pigs (live weights 24-46 and 49-139 kg) were stained for glycogen (PAS) and a mitochondrial enzyme (NAD tetrazolium reductase). Administration of caffeine in 125 mg increments produced a syndrome strongly resembling malignant hyperpyrexia in rabbits anesthetized with halothane.

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Methylated Host Cell Gene Promoters and Human Papillomavirus Type 16 and 18 Predicting Cervical Lesions and Cancer. Doppler ultrasonography--perinatal data in cases with end-diastolic block and reverse flow. Immunohistochemical evidence for sclerostin during cementogenesis in mice. An experimental study on hypoxia loading, especially on its relationship to thyroid function. After a 2010 needs assessment, we conducted 2 statewide workshops targeting 6 of the Ten Steps found to be most deficient among New Hampshire birthing hospitals. In addition, the findings that maternal exposure to various CNS acting drugs resulted in a marked sex difference in the brain function of the offspring when assessed with a number of measures such as open-field behavior, tolerance to the exposed drug itself, thermic responses to chlorpromazine, and the pituitary response to releasing hormones were presented and discussed. Ricin(II)-agarose lectin affinity chromatography, oligomapping, and monosaccharide analyses provided evidence that Lec19 N-glycans have fewer Gal residues than CHO N-glycans. HEART STROKE VOLUME, VENOUS ADMIXTURE AND RESPIRATORY DEAD SPACE DURING CHANGES IN THE MEAN INTRAPULMONARY PRESSURE ON THE ARTIFICALLY VENTILATED DOG. 14-3-3 proteins are involved in many physiological and pathological cellular processes either by triggering or interfering with the activity of specific protein partners.

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The bursts of EA (10-11 oscillations per s) with maximum amplitude and duration in locus coeruleus (LC) correspond to the syndrome of anxiety. The aim of this study was to investigate the effect of cavity design and the type of pulp capping materials on the fracture resistance of Class II composite restorations. The inability to wait for a large, delayed reward when faced with a small, immediate one, known as delay discounting, has been implicated in a number of disorders including substance abuse. Normal laboratory parameters and no radiological signs of an ongoing inflammatory process were observed during follow-up examinations. Overexpression of reggie-1 resulted in the induction of numerous filopodia-like protrusions in various cell lines, suggesting a role for reggie-1 as a signalling protein in actin-dependent processes. Despite this clear advice from NHMRC and the financial incentives provided by Medicare and the PBS, less than one in three of this vulnerable cohort receives the vaccine. A correct impression can be secured the first time, overcoming further discomfort and inconvenience to the patient. If the infection is serious, a bacteriocidal agent should be selected in preference to a bacteriostatic agent. Two New Species of Marine Saprotrophic Sphaeroformids in the Mesomycetozoea Isolated From the how much does cytoxan cost Sub-Arctic Bering Sea. First, does the use of earplugs during the night reduce the onset of delirium or confusion in the ICU?.

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This review highlights the interactive cross-modal compensation within sensory systems that can occur that reduces the likelihood of identifying these losses in less sentient animals used in standard preclinical toxicology and safety protocols. Freeze-clamped studies showed an increase in glycogen levels upon insulin treatment of the glucose perfused rat heart. Further research is required to examine this issue in more detail. In the first-trimester, prilosec medicine ST contains a large amount of hCG which sharply diminishes thereafter, but hPL in ST increases with the fetal age. The quality of trials was assessed according to the Jadad five-point scale. The assessment was made after the first hospitalization, and then after three and twelve years. The natural history of carcinogenesis: implications of experimental carcinogenesis in the genesis of human cancer. NCDs were observed to have higher prevalence in subjects who were illiterate and married, speaking Punjabi language, and belonged to higher age groups and nuclear families. However, over the last 20 years there has been a series of stepwise advances resulting from laboratory studies and clinical observations which have resulted not only in a better understanding of this disease but in successful therapeutic applications as well. Interplay of delay and multiplexing: Impact on cluster synchronization.

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Angiotensin II-positive autonomic fibres with and without a catecholaminergic cophenotype (hydroxylase-positive) were found in all parts of the human ventricles. Mucosal biopsies were taken from 20 ears with secretory otitis media (glue ear) and histochemical stainings were made for comparison with data obtained from biochemical analysis of the fluids. A brief mention of postoperative blood salvage drains is also included. Letter: Biphasic tumour-enhancing and tumour-inhibiting effects of non-specific immunotherapy. Collectively, the results show that human cells are exquisitely sensitive to the amount of HP1(Hsalpha) or HP1(Hsbeta) present, as their overexpression influences telomere stability, population doubling time, radioresistance, and tumorigenicity in a mouse xenograft model. It is based on the analysis of articles indexed in Medline and is calculated by taking into account the place of the author and the ranking of the journal according to the disciplinary field. A case of cholecystitis secondary to radiofrequency treatment of a similarly-located tumor has ramipril dosage previously been described and, therefore, the use of percutaneous local destructive treatments for tumors close to the gallbladder would seem unadvisable.

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