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Adnil (Clonazepam)

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Clonazepam, sold under the brand name Klonopin among others, is a medication used to prevent and treat seizures, panic disorder, and for the movement disorder known as akathisia. It is a tranquilizer of the benzodiazepine class. It is taken by mouth. It begins having an effect within an hour and lasts between six and 12 hours. Adnil was initially patented in 1964 and went on sale in the United States in 1975. It is available as a generic medication.

Other names for this medication:
Adnil, Almac, Azpax, Cleps, Clonark, Clonatrac, Clonaxyl, Clonopam, Clopam, Closis, Clozipam, Clozorix, Deptune, Dipwell, Easyfeel, Eminaz, Epicloz, Epitril, Epizam, Escimax, Escitrac, Esitor, Jbcloz, Lonazep, Lozep, Melzap, Nozim, Nupam, Ozepam, Prasilex, Sezolan, Somnotril, Ubitpam, Xenotril, Xitzen, Zepam

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Also known as: Clonazepam


Clonazepam is used alone or together with other medicines to treat certain seizure disorders (eg, Lennox-Gastaut syndrome, akinetic, myoclonic, and absence seizures). It is also used to treat panic disorder. Clonazepam is a benzodiazepine that works in the brain to prevent seizures. Benzodiazepines are central nervous system (CNS) depressants, which are medicines that slow down the nervous system.

This medicine is available only with your doctor's prescription.


Adults. The initial dose for adults with seizure disorders should not exceed 1.5 mg/day divided into three doses. Dosage may be increased in increments of 0.5 to 1 mg every 3 days until seizures are adequately controlled or until side effects preclude any further increase. Maintenance dosage must be individualized for each patient depending upon response. Maximum recommended daily dose is 20 mg. The use of multiple anticonvulsants may result in an increase of depressant adverse effects. This should be considered before adding Adnil to an existing anticonvulsant regimen.

Pediatric Patients. Adnil is administered orally. In order to minimize drowsiness, the initial dose for infants and children (up to 10 years of age or 30 kg of body weight) should be between 0.01 and 0.03 mg/kg/day but not to exceed 0.05 mg/kg/day given in two or three divided doses. Dosage should be increased by no more than 0.25 to 0.5 mg every third day until a daily maintenance dose of 0.1 to 0.2 mg/kg of body weight has been reached, unless seizures are controlled or side effects preclude further increase. Whenever possible, the daily dose should be divided into three equal doses. If doses are not equally divided, the largest dose should be given before retiring.

Geriatric Patients. There is no clinical trial experience with Adnil in seizure disorder patients 65 years of age and older. In general, elderly patients should be started on low doses of Adnil and observed closely.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, or coma.


Tablets should be kept at room temperature, between 15 C and 30 C (59 F and 86 F).

Side effects

The most common side effects associated with Adnil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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Carbon nanocones/disks as new coating for solid-phase microextraction. Existing studies indicate a significant genetic component for sudden cardiac arrest (SCA) and genome-wide association studies (GWAS) provide an unbiased approach for identification of novel genes. To assess the anti-tumour and side effects of paclitaxel in patients with ovarian carcinoma, after prior treatment with al least one platinum-containing chemotherapy regimen. Structural specificity of chloroquine-hematin binding related to inhibition of hematin polymerization and parasite growth. By identifying similar high affinity binding sites in potential target genes of the Pax2 protein, including the pax2 gene itself, we obtained further evidence that the triple-A sites are biologically significant.

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Swarming and swimming were enhanced only in dam mutant and biofilm formation increased significantly in all tested strains after UV-C exposure. The active component of ES-62 appears to be PC, as the results obtained with ES-62 are broadly mimicked by PC conjugated to BSA or PC alone. The endoscopic examination of the stomach disclosed gastric cancer in the posterior wall of the antrum and the biopsy showed signet-ring cell carcinoma. holbrooki, Xenotoca eiseni, Phoxinus phoxinus, Pterophyllum scalare, Xenopoecilus sarasinorun, and Trichogaster trichopterus. Further, it has been hypothesized that the lower nasal region of the lens is the most susceptible to damage by environmental ultraviolet light exposure. A randomized, multicenter, active-controlled trial to compare the efficacy of recombinant human parathyroid hormone (1-34) with that of elcatonin in postmenopausal women with osteoporosis in China. Action of the 4-nitro-2-phenoximethanesulphonanilide (nimesulide) on neutrophil chemotaxis and superoxide production.

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The significance of nuclear sex dimorphism in chromosomal findings. Photosynthesis of succinic acid by Chlorobium thiosulphatophilum. However, randomized clinical trials are needed to confirm this conclusion. In 16 of 18 hips, the labrum regenerated to the extent that dense fibrous scar extending from the surgically denuded origin filled the defect. Despite highly promising results in many animal studies, clinical studies have been disappointing.

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Short-term down-regulation of the brain-specific, PtdIns(3,4,5)P3/Ins(1,3,4,5)P4-binding, adapter protein, p42IP4/centaurin-alpha 1 in rat brain after acoustic and electric stimulation. Early and serious bronchial mutilations after antibiotic cure of certain cases of pulmonary tuberculosis. The clinico-anatomical principle and principle of the structural-functional unity have been underlying in the research activities of the pathology chair as long as 150 years of its existence. The method used is based on the local state isomorphism theorem. How beverage taxes might influence purchases of foods and beverages among households with preschool children is unclear.

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Futile recanalization in mechanical embolectomy trials: a call to improve selection of patients for revascularization. It appears that individuals with ASC are unaffected in perceptual processing of form-from-motion, but may exhibit impairments in higher order judgments such as emotion processing. MiR-124 inhibited glioma cell growth, invasion, angiogenesis, and tumor growth and increased chemosensitivity to temozolomide treatment by negatively regulating the Ras family and its downstream signaling pathways: phosphatidylinositol-3 kinase/Akt and Raf/extracellular signal-regulated kinase 1/2. Detailed protocols are presented for assembling anchored nuclei in a Xenopus cell-free reconstitution system and for the exposure of the nuclear surface in mammalian cell nuclei. CK2 modulation of NF-kappaB, TP53, and the malignant phenotype in head and neck cancer by anti-CK2 oligonucleotides in vitro or in vivo via sub-50-nm nanocapsules. Endoscopic axillary lymphadenectomy can be done safely without prior liposuction. Severe ethylene glycol toxicity can cause profound morbidity and is almost universally fatal if untreated. Human bone marrow-derived mesenchymal stem cells induced toward osteogenesis were cultured in the presence or absence of 50 mM alcohol. Adult victims of work-related injury who presented to an urban public hospital ED from 1 December 1998 to 31 May 1999 were interviewed.

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Cigarette Excise Taxes in Context: Cautionary Lessons from the U.S. Neuromagnetic spectral power in the motor cortex in migraineurs was significantly elevated. Both in vitro and in vivo methyltransferase assays revealed that SMYD2 could methylate HSP90AB1 and mass spectrometry analysis indicated lysines 531 and 574 of HSP90AB1 to be methylated. Sedation in children is increasingly emerging as a minimally invasive technique that may be associated with local anaesthesia or diagnostic and therapeutic procedures which do not necessarily require general anaesthesia. Hospital board oversight of quality and safety: a stakeholder analysis exploring the role of trust and intelligence. It is of particular concern that women with preeclampsia or in premature labor are at high risk for abruptio placentae with consequent compromise of fetal oxygenation. Passive resistive torque and maximum voluntary contraction were measured with a dynamometer. We prospectively collected clinicopathologic data and measured the methylation levels of HAND1, THBD, APC, and MOS in the gastric mucosa by methylation-specific real-time polymerase chain reaction in patients who underwent endoscopic resection of gastric neoplasms. We argue that ocean conditions are already more extreme than those experienced by marine organisms and ecosystems for millions of years, emphasising the urgent need to adopt policies that drastically reduce CO(2) emissions.

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Thrombotic thrombocytopenic purpura: a simpler diagnosis at last?. (2) Islet glycolysis and/or the re-oxidation of cytoplasmic NADH allowed the maintenance of an elevated, though non-oscillating, intracellular calcium concentration, but a reduced response to glucose. The data suggest that the decrease in receptor density is due to a decrease in steady-state mRNA abundance. Educating PCPs on the appropriate referral of CKD patients, especially those at risk for late or non-referral to a nephrologist is warranted, as are trials assessing different educational strategies. Saffman-Taylor instability of viscoelastic fluids: from viscous fingering to elastic fractures. If such approaches are to find a role in therapy, it is likely that it will be restricted: perhaps for the treatment of refractory ulcers, or for prophylaxis of stress ulceration. Coronavirus survival on healthcare personal protective equipment. The incidence of invasive fungal infections (IFIs) in nonneutropenic solid organ transplant patients is increasing.

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Active electrode IC for EEG and electrical impedance tomography with continuous monitoring of contact impedance. Evaluation of the residual liquid junction potential contribution to the uncertainty in pH measurement: a case study on low ionic strength natural waters. With a few exceptions, F-homozygotic dogs had no hepatocellular alpha-1 antitrypsin accumulation. However, linear regression did not find an association between DRD4 VNTR and MAXDRINKS, which was defined as the maximum number of drinks consumed within 24h. Increases in intensity of 5-HT immunoreactivity in the dorsal raphe nucleus and decreases in the number of 5-HT-immunoreactive cell can i use tetracycline antibiotic while breastfeeding bodies in the dorsal and the median raphe nuclei were detected. Soya in diet therapy of nutritional disorders: soya in diet therapy of other diseases.

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Some new data on the interaction of corticoids and electrolytes in the tissues. This study was carried out to compare the intraoperative and postoperative results of conventional surgery of the thoracic spine by thoracotomy with those of the thoracoscopic technique to determine the advantages of this new approach. All patients with ACS had high values of platelet aggregation stimulated by adenosine diphosphate in dose 0.1 uM. The thermal responses of nickel, iron and copper heating units were studied by applying an alternating magnetic field as a function of geometry of unit, strength of magnetic field, and kind of metal. At later stages, the OTX2 protein was found in the subcommissural organ, pineal gland, and cerebellum. In mania, metabolism increases in the dorsal cingulate cortex, striatal regions, and the nucleus accumbens, as well as in limbic structures of the temporal lobes, but decreases in dorsolateral prefrontal cortex, possibly reflecting its loss of modulatory control over limbic structures. Adequate sample size with good follow up data is necessary before concluding that it can be safe alternative to surgery on long term. Studies on the presence of tubercle bacilli in sewage utilized for agricultural purposes. Electrochemical and photoelectrochemical investigation of new electrostatic self-assembled films based on Prussian blue and a binuclear Ru(II) complex. fulgidus open reading frame tramadol 50 mg iv injection , AF0394, which is predicted to encode a D-(-)-lactate dehydrogenase (Dld), was cloned, and its product was expressed in Escherichia coli as a fusion with the maltose binding protein (MBP).

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Structured telephone interview survey of randomly selected householders in Townsville. Clinical and histopathological correlation of duodenal biopsy with IgA anti-tissue transglutaminase titers in children with celiac disease. prazosin generic drug In addition to direct effects associated with altered NO production (e.g. Blast results indicated that the PCR products were consistent with the Plasmodium ovale reference sequence in GenBank. The presence of coronary steal phenomenon was detected by dobutamine stress myocardial imaging.

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Spaced and massed practice with a methodological consideration of avoidance conditioning. One-dimensional integrals, used for the numerical computations, are derived for the fields, powers, and decay enhancements. The present nested PCR appears a simple, rapid and valuable method for diagnosing AINO and AKA infection. There are only three reported cases of HH associated with a mosaic, r(X) Turner syndrome. Reverse intermetamorphosis--a rare misidentification phenomenon. For a rational implementation of strategies exploitable for the prevention smoking-related diseases, it is crucial to elucidate both the mechanisms of action of cigarette smoke and the protective mechanisms of the host organism. The type and time of menopause as decisive factors for bone mass changes. Dynamic changes in sleep-related breathing abnormalities in bilateral paramedian mesencephalon and thalamus stroke: a follow-up case study. The breakthrough in applying this new type of microscopy is also due to the fact that the images can be digitally collected at very high resolution in the z-axis, without the need to adopt the critical point-drying method or vacuum conditions, and without the need to coat the surface of the sample with a metal layer, a result not otherwise attainable with other microscopy techniques. In the group that underwent subcutaneous treatment with CO(2) therapy, the results highlighted indocin gout dose a significant increase in tissue oxygenation values, which was confirmed by greater progress of the lesions in terms of both healing and reduction of the injured area.

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