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Adnil (Clonazepam)
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Adnil

Clonazepam, sold under the brand name Klonopin among others, is a medication used to prevent and treat seizures, panic disorder, and for the movement disorder known as akathisia. It is a tranquilizer of the benzodiazepine class. It is taken by mouth. It begins having an effect within an hour and lasts between six and 12 hours. Adnil was initially patented in 1964 and went on sale in the United States in 1975. It is available as a generic medication.

Other names for this medication:
Adnil, Almac, Azpax, Cleps, Clonark, Clonatrac, Clonaxyl, Clonopam, Clopam, Closis, Clozipam, Clozorix, Deptune, Dipwell, Easyfeel, Eminaz, Epicloz, Epitril, Epizam, Escimax, Escitrac, Esitor, Jbcloz, Lonazep, Lozep, Melzap, Nozim, Nupam, Ozepam, Prasilex, Sezolan, Somnotril, Ubitpam, Xenotril, Xitzen, Zepam

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Adipex, Arimidex, Robaxin, Seroquel, Bactrim, Alprostadil, Xalatan

Also known as: Clonazepam

Description

Clonazepam is used alone or together with other medicines to treat certain seizure disorders (eg, Lennox-Gastaut syndrome, akinetic, myoclonic, and absence seizures). It is also used to treat panic disorder. Clonazepam is a benzodiazepine that works in the brain to prevent seizures. Benzodiazepines are central nervous system (CNS) depressants, which are medicines that slow down the nervous system.

This medicine is available only with your doctor's prescription.

Dosage

Adults. The initial dose for adults with seizure disorders should not exceed 1.5 mg/day divided into three doses. Dosage may be increased in increments of 0.5 to 1 mg every 3 days until seizures are adequately controlled or until side effects preclude any further increase. Maintenance dosage must be individualized for each patient depending upon response. Maximum recommended daily dose is 20 mg. The use of multiple anticonvulsants may result in an increase of depressant adverse effects. This should be considered before adding Adnil to an existing anticonvulsant regimen.

Pediatric Patients. Adnil is administered orally. In order to minimize drowsiness, the initial dose for infants and children (up to 10 years of age or 30 kg of body weight) should be between 0.01 and 0.03 mg/kg/day but not to exceed 0.05 mg/kg/day given in two or three divided doses. Dosage should be increased by no more than 0.25 to 0.5 mg every third day until a daily maintenance dose of 0.1 to 0.2 mg/kg of body weight has been reached, unless seizures are controlled or side effects preclude further increase. Whenever possible, the daily dose should be divided into three equal doses. If doses are not equally divided, the largest dose should be given before retiring.

Geriatric Patients. There is no clinical trial experience with Adnil in seizure disorder patients 65 years of age and older. In general, elderly patients should be started on low doses of Adnil and observed closely.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, or coma.

Storage

Tablets should be kept at room temperature, between 15 C and 30 C (59 F and 86 F).

Side effects

The most common side effects associated with Adnil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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Carbon nanocones/disks as new coating for solid-phase microextraction. Existing studies indicate a significant genetic component for sudden cardiac arrest (SCA) and genome-wide association studies (GWAS) provide an unbiased approach for identification of novel genes. To assess the anti-tumour and side effects of paclitaxel in patients with ovarian carcinoma, after prior treatment with al least one platinum-containing chemotherapy regimen. Structural specificity of chloroquine-hematin binding related to inhibition of hematin polymerization and parasite growth. By identifying similar high affinity binding sites in potential target genes of the Pax2 protein, including the pax2 gene itself, we obtained further evidence that the triple-A sites are biologically significant.

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The significance of nuclear sex dimorphism in chromosomal findings. Photosynthesis of succinic acid by Chlorobium thiosulphatophilum. However, randomized clinical trials are needed to confirm this conclusion. In 16 of 18 hips, the labrum regenerated to the extent that dense fibrous scar extending from the surgically denuded origin filled the defect. Despite highly promising results in many animal studies, clinical studies have been disappointing.

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Cigarette Excise Taxes in Context: Cautionary Lessons from the U.S. Neuromagnetic spectral power in the motor cortex in migraineurs was significantly elevated. Both in vitro and in vivo methyltransferase assays revealed that SMYD2 could methylate HSP90AB1 and mass spectrometry analysis indicated lysines 531 and 574 of HSP90AB1 to be methylated. Sedation in children is increasingly emerging as a minimally invasive technique that may be associated with local anaesthesia or diagnostic and therapeutic procedures which do not necessarily require general anaesthesia. Hospital board oversight of quality and safety: a stakeholder analysis exploring the role of trust and intelligence. It is of particular concern that women with preeclampsia or in premature labor are at high risk for abruptio placentae with consequent compromise of fetal oxygenation. Passive resistive torque and maximum voluntary contraction were measured with a dynamometer. We prospectively collected clinicopathologic data and measured the methylation levels of HAND1, THBD, APC, and MOS in the gastric mucosa by methylation-specific real-time polymerase chain reaction in patients who underwent endoscopic resection of gastric neoplasms. We argue that ocean conditions are already more extreme than those experienced by marine organisms and ecosystems for millions of years, emphasising the urgent need to adopt policies that drastically reduce CO(2) emissions.

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Thrombotic thrombocytopenic purpura: a simpler diagnosis at last?. (2) Islet glycolysis and/or the re-oxidation of cytoplasmic NADH allowed the maintenance of an elevated, though non-oscillating, intracellular calcium concentration, but a reduced response to glucose. The data suggest that the decrease in receptor density is due to a decrease in steady-state mRNA abundance. Educating PCPs on the appropriate referral of CKD patients, especially those at risk for late or non-referral to a nephrologist is warranted, as are trials assessing different educational strategies. Saffman-Taylor instability of viscoelastic fluids: from viscous fingering to elastic fractures. If such approaches are to find a role in therapy, it is likely that it will be restricted: perhaps for the treatment of refractory ulcers, or for prophylaxis of stress ulceration. Coronavirus survival on healthcare personal protective equipment. The incidence of invasive fungal infections (IFIs) in nonneutropenic solid organ transplant patients is increasing.

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