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Alfacal (Calcitriol)
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Alfacal

Alfacal is a man-made active form of vitamin D. Most people get enough vitamin D from exposure to the sun and from fortified food products. Vitamin D helps control parathyroid hormone and the levels of certain minerals that are needed for building and keeping strong bones.

Other names for this medication:
Alfacal, Alfarich, Alphadol, Apcical, Arachitol, Biocal, Calasto, Calbec, Calcibest, Calcicare, Calcigra, Calcirol, Calcit, Calcor, Caldikind, Caldix, Calfa, Calgel, Calosto, Caltive, Carcal, Cholical, Citroj, Estovon, Koncal, Lctrol, Minroset, Netxod, Novadee, Nutribone, Osteobel, Ostriol, Politrol, Primacal, Qpcal, Rical, Romical, Septriol, Statbone, Trolec, Vezocal

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Also known as: Calcitriol

Description

Generic Alfacal is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Alfacal are intestine and bone. Generic Alfacal receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Alfacal may also act on the kidney and the parathyroid glands. Generic Alfacal is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Alfacal has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Alfacal, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Alfacal in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Alfacal produces other independent beneficial effects. Alfacal is also known as Calcitriol. Generic Alfacal treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Alfacal is Calcitriol. Brand name of Generic Alfacal is Alfacal.

Dosage

This section provides information on the proper use of a number of products that contain vitamin d and related compounds. It may not be specific to Alfacal. Please read with care.

For use as a dietary supplement:

Do not take more than the recommended daily amount. Vitamin D is stored in the body, and taking too much over a period of time can cause poisoning and even death.

If you have any questions about this, check with your health care professional.

For individuals taking the oral liquid form of this dietary supplement:

This preparation should be taken by mouth even though it comes in a dropper bottle. This dietary supplement may be dropped directly into the mouth or mixed with cereal, fruit juice, or other food.

While you are taking alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, doxercalciferol or paricalcitol , your health care professional may want you to follow a special diet or take a calcium supplement. Be sure to follow instructions carefully. If you are already taking a calcium supplement or any medicine containing calcium, make sure your health care professional knows.

The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For alfacalcidol To treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For parenteral dosage form (injection): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 12 mcg a week. To treat diseases in which calcium is not used properly by the body: For oral dosage form (capsules): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 0.25 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day.

For calcifediol To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults, teenagers, and children over 10 years of age—At first, 300 to 350 micrograms (mcg) a week, taken in divided doses either once a day or every other day. Your doctor may change your dose if needed. Children 2 to 10 years of age—50 mcg a day. Children up to 2 years of age—20 to 50 mcg a day. To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage forms (capsules and solution): Adults, teenagers, and children—At first, 0.25 micrograms (mcg) a day. Your doctor may change your dose if needed. For parenteral dosage forms (injection): Adults and teenagers—At first, 0.5 mcg injected into a vein three times a week. Your doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For dihydrotachysterol To treat diseases in which calcium is not used properly by the body: For oral dosage forms (capsules, solution, or tablets): Adults and teenagers—At first, 100 micrograms (mcg) to 2.5 milligrams (mg) a day. Your doctor may change your dose if needed. Children—At first, 1 to 5 mg a day. Your doctor may change your dose if needed.

For doxercalciferol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—10 micrograms (mcg) three times weekly at dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For ergocalciferol The amount of vitamin D to meet normal daily recommended intakes will be different for different individuals. The following information includes only the average amounts of vitamin D. To prevent deficiency, the amount taken by mouth is based on normal daily recommended intakes: For oral dosage form (capsules): For the U.S. Adults and teenagers—5 to 10 micrograms (mcg) (200 to 400 Units) per day. Pregnant and breast-feeding females—10 mcg (400 Units) per day. Children 4 to 10 years of age—10 mcg (400 Units) per day. Children birth to 3 years of age—7.5 to 10 mcg (300 to 400 Units) per day. For Canada Adults and teenagers—2.5 to 5 mcg (100 to 200 Units) per day. Pregnant and breast-feeding females—5 to 7.5 mcg (200 to 300 Units) per day. Children 7 to 10 years of age—2.5 to 5 mcg (100 to 200 Units) per day. Children 4 to 6 years of age—5 mcg (200 Units) per day. Children birth to 3 years of age—5 to 10 mcg (200 to 400 Units) per day. To treat deficiency: Adults, teenagers, and children—Treatment dose is determined by prescriber for each individual based on severity of deficiency. To treat diseases in which calcium and phosphate are not used properly by the body: Adults and teenagers—At first, 1000 to 500,000 Units a day. The doctor may change your dose if needed. Children—At first, 1000 to 200,000 Units a day. The doctor may change your dose if needed.

For paricalcitol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—1 to 2 micrograms (mcg) one time per day or 2 to 4 mcg three times a week (not more often than every other day). The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor. For parenteral dosage form (injection): Adults—0.04 to 0.1 micrograms (mcg) per kg no more than every other day during dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Generic Alfacal and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Side effects

The most common side effects associated with Alfacal are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

If you are taking a dietary supplement without a prescription, carefully read and follow any precautions on the label. For these supplements, the following should be considered:

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Recurrent hepatoblastoma in orthotopic transplanted liver: detection with FDG positron emission tomography. Parental refusal to have children immunised: extent and reasons. Central bisegmentectomy of the liver and extrahepatic bile duct resection was performed. Metabolic differences in estrogen receptor-negative breast cancer based on androgen receptor status. The tolerability of intramuscular ziprasidone and haloperidol treatment and the transition to oral therapy. TBLR1 is a novel prognostic marker and promotes epithelial-mesenchymal transition in cervical cancer.

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Radiation injuries of the ribs in preoperative radiotherapy of breast cancer. We investigated whether genomic copy number variations of the beta-defensin gene cluster have a functional role in airway epithelial cells and associate with the presence of COPD. With the realization of the important role innate immunity plays in orchestrating immune responses, invertebrates such as worms and flies have been added to the repertoire. The Blood glucose, lipid and serum insulin were measured before and after the treatment, and the changes in gene expression among four groups were studied by mRNA differential display technique. Non-planning impulsivity, defined as a lack of future orientation, has been demonstrated to be the main impulsivity domain altered during euthymia in bipolar disorder patients. Guidelines for sclerotherapy of varicose veins (ICD 10: I83.0, I83.1, I83.2, and I83.9). Management of rodent viral disease outbreaks: one institutions (r)evolution. In this study we report an increase in the number of nucleoli in fibroblast cells from 3 patients with GS after x-radiation.

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A loading dose of morphine (50 micro g kg(-1)) was administered in the perioperative period. Consequential late effects play a major role after radiotherapy for prostate cancer. These hybrid enzymes introduce a variety of new monomer-sequence patterns into their substrates, and some regions important for the subsite specificity or processivity of the enzymes were identified. The role of the nervous system in the maintenance of venous hypertension in heart failure. Anabolic steroid use by adolescents: prevalence, motives, and knowledge of risks. We performed a systematic review of randomized controlled trials and searched for all-language publications in the Cochrane Controlled Trials Register, MEDLINE, EMBASE, and CINAHL in April 2002. This mutation is associated with neurogenic muscle weakness, ataxia and retinitis pigmentosa (NARP) and the neurodegenerative condition, Leigh syndrome. TMG could be useful in establishing skeletal-muscle fatigue status without exacerbating the functional decrement of the muscle. Their established benefits for the patients are likely to cause their widespread use in the future.

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We term the current procedure as polymer-coated hollow fiber microextraction (PC-HFME). Two degradation products were identified with a hybrid ESI-Q-TOF mass spectrometer. Three non-steroidal anti-androgens are available in the US, i.e. A novel stop codon mutation in the PMP22 gene associated with a variable phenotype. These features comprise a mobile domain called the lid that controls access to the catalytic site. gondii in the fibroblast cells was significantly inhibited by treatment with 200-300 U/ml ov.rIFN gamma, whereas concentrations as low as 1 U/ml suppressed parasite replication in the alveolar macrophages. A uniform spherical structure with particle size of 200-500 nm was found in SEM. This could coincide with stress-induced malfunction of the hippocampal declarative memory system.

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In infants with feeding difficulties, a MBSW may demonstrate aspiration when the UGI is negative. Moving forward to improve the diagnosis and treatment of refractory asthma. Neuropsychologic traits in individuals with chronic exposure to mercury at work. The preoperative height and lateral width of both SMH and pigment epithelial detachment documented with optical coherence tomography, were measured. Randomized trial of cohesive short-stretch versus four-layer bandaging in the management of venous ulceration. This study assessed the effects of using Xpert in place of conventional solid and liquid culture and drug-susceptibility testing on case detection rates, treatment initiation rates, and health system delays among drug-resistant tuberculosis (TB) patients. Based on these results and the original definition by Yakovlev and Wadsworth, the following two conclusions were suggested.

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Production of ascites by gradual occlusion of the hepatic Veins with an internal vena caval cannula. The presence of orthostatic hypotension was associated with increasing tendency of WMH score and the blood pressure changes during tilting and supine blood pressure were positively correlated with increasing WMH score. Results showed a reduced corrosion rate and good biocompatibility of the SLM produced magnesium with PCL coating. Based on these results, the authors hypothesize that stimulating the contralateral femoral nerve to produce SSEPs and then analyzing the distribution of the SSEPs may provide a method for functional localization of the sensorimotor cortex around the interhemispheric fissure during craniotomy. The advantages and pitfalls of this technique are described and compared with other classic approaches. Rotary processing is an efficient multistage, single-pot spheroid production method. Mutations in the IGF-I receptor (IGF1R) gene can be responsible for intrauterine and postnatal growth disorders. To compare the strength-duration (S-D) time constants of motor cortex structures activated by current pulses oriented posterior-anterior (PA) or anterior-posterior (AP) across the central sulcus. Recent comparative studies of the effects of general anaesthetics across a structurally homologous family of inhibitory amino acid receptors that includes mammalian GABAA, glycine and Drosophila RDL GABA receptors have provided new insights into the structural basis of anaesthetic action at transmitter-gated channels. Using a simple extension of the wormlike chain model, we study the response of a weakly bending filament in two dimensions to a pulling force applied at its ends (a configuration common in classical in-vitro experiments and relevant to several in-vivo cell cases).

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Recovery from blindness following removal of suprasellar epidermoid. We now review the molecular biology of urothelial bladder carcinoma and discuss clinical applications of biomarkers and targeted therapies. In the left eye, there was an area of retinal elevation and whitening involving the peripheral retina. In the current study, we evaluated whether multiple psychological factors predict poor functional outcome in individuals with schizophrenia, and whether associations between psychological variables and functional outcome persist even after accounting for neuropsychological impairment and negative symptoms. The present study investigates whether these phenotypes of STAT5b-deficient mice result from impaired intracellular GH signaling associated with a loss of GH pulse responsiveness, as contrasted with a feminization of the pituitary GH secretory profile leading to the observed feminization of body growth and liver gene expression. Nursing home residents are a continuously growing population with a need for intense pharmacotherapy due to numerous comorbid conditions. The complement fixation reaction with treponemal protein extract (Reiter strain) in the diagnosis of human treponematosis. Morphologic study of the efferent ductules of the pigeon (Columba livia). Optic atrophy as the presenting sign in Hallervorden-Spatz syndrome. Hospitalizations of nursing home residents with dementia may not be uncommon.

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Second primary tumors in the head and neck of patients with cancer are not uncommon. Hyperextension vertebral body fractures in diffuse idiopathic skeletal hyperostosis: a cause of intravertebral fluidlike collections on MR imaging. In this article, we reconcile these pathways and elements by presenting a graphic image for clinicians and teachers in medical education. He underwent C1LM-C2P fixation for stabilization of type II odontoid process fracture described by Harms. Taken together, these results suggest that ALK7 induces apoptosis through activation of the traditional TGF-beta pathway components, thus resulting in new gene transcription and JNK and p38 activation that initiates cross-talk with the cellular stress death pathway and ultimately leads to apoptosis. This technique holds promise for clinical studies and therapeutic trials. Compound 1 is a new Lycopodium alkaloid, and compound 3 was obtained from nature for the first time. Mortality from ischemic cardiopathy in Spain: the trends and geographic distribution. The aim of this study was to analyze differential features of patients in these two groups as they behaved dissimilarly in regard to clinical significance and outcomes, especially those concerning infectious risk.

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Although anxiety disorders are more prevalent during the perinatal period, little attention has been given so far to the influence that pregnancy and the post-partum period can have on anxiety disorders. Percentage body fat was measured via dual-energy x-ray absorptiometry (DEXA) and with a portable bioimpedance monitor, and body condition score (BCS) was measured by use of a 9-integer scale. Data covering 7 years of daily monitoring of river water turbidity and concentrations of E. Multifaceted diagnostic approach to myocardial cell injury based on quantitative as well as qualitative cTnT and CK-MB/CK measurements, electrocardiographic (ECG) and echocardiographic (TTE) findings. Even an aristocort generic name increase in vagal tone caused by the insertion of a bladder catheter can acutely decrease preload and lead to cardiogenic shock. Results revealed six pedagogy profiles that were classified in terms of three broad types of performances delivered by after-school staff: (1) positive youth development, (2) staff-centered, and (3) low-quality. Release of silver and copper nanoparticles from polyethylene nanocomposites and their penetration into Listeria monocytogenes. Chronic airway diseases, such as asthma and chronic obstructive pulmonary disease, are characterized by airway remodeling. Determination of hormones, a plasticizer, preservatives, perfluoroalkylated compounds, and a flame retardant in water samples by ultrasound-assisted dispersive liquid-liquid microextraction based on the solidification of a floating organic drop. The patients should be told that the effectiveness and success of this therapy cannot be predicted in advance.

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Little is known about the mechanisms of intracellular targeting of viral nucleic acids within infected cells. Increased frequency of Autism Spectrum Disorder (ASD) diagnosis, increased ASD symptom severity, and increased prevalence of macrocephaly were observed in the duplication relative to deletion carriers, whereas reciprocally increased prevalence of microcephaly was observed in the deletion carriers. In addition, ATX expression was examined in normal human hepatocytes and liver cancer cell lines. Recurrent meningiomas--the immunohistochemical analysis of angiogenesis and cellular proliferation. Protein-protein interactions (PPI) are essential in every step of the HIV replication cycle. Chimeric alpha-factor receptors in which a portion (residues 250-303) of the seven hydrophobic segments were derived from the k-alpha FR and the rest from c-alpha FR conferred potent activation of cellular responses by dTA-alpha-factor including induction of FUS1 expression without significantly affecting binding. Brain edema, neurological deficits and neuronal damage were also ameliorated. The authors manipulated procedural justice and the outcome valence of the decision frame within a vignette, and measured justice orientation of 174 Japanese participants. Development and Application of O-(Trimethylsilyl)aryl Fluorosulfates for the Synthesis of Arynes. Enhanced spontaneous and/or evoked release could contribute to increased SNA frequency.

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The Role of Microvesicles Derived from Mesenchymal Stem Cells in Lung Diseases. Three-gamma annihilation imaging in positron emission tomography. Percutaneous coronary intervention in patients with a history of previous coronary artery bypass grafting (CABG) is associated with an increased rate of subsequent adverse events compared to those without prior CABG. Thirty-two pediatric primary care clinicians used a brief (3- to 5 bactrim and alcohol reviews -minute) evidence-based behavior change intervention with low-income mothers of children aged 2-4 years during each regularly scheduled clinic visit over a 12-month period to target 4 specific obesogenic behaviors (milk consumption, juice and sugar-sweetened beverage consumption, television/screen time, and physical activity). Diagnostic value of automated 3D ultrasound for incisional hernia. Relationship between gene polymorphism at CETP locus and hyperlipidemia in the middle-aged and the elder. Chondromyxoid fibroma of the scapula associated with aneurysmal bone cyst.

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Advantages are a less invasive procedure and rapid restitution of blood flow. The development of the green fluorescent protein (GFP) as a marker for intracellular protein localization has allowed for the real time study of protein localization and dynamics in living cells. Transperineal and endovaginal ultrasound can both be used to analyze hiatus area and anteroposterior diameter with the patient at rest and to diagnose levator avulsion. Influence of actinomycins on the content of 17-hydroxy-corticosteroids in guinea pig plasma. trachomatis is more commonly found in the general population than was previously believed, its role in reactive arthritis may well be currently overlooked.

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These changes in dental insurance coverage are unlikely to challenge the traditional model of dental practice within the next five years, largely because of the growing decline in the supply of dental services and a lack of local market concentration of dental managed care companies. Like its murine homolog Rig1/ norvasc tabs Robo3, but unlike other Robo proteins, ROBO3 is required for hindbrain axon midline crossing. Results indicate that the motivational priming effect on startle modulation elicited by different picture categories is independent of emotion regulation instructions. Progression of nuclear sclerosis based on changes in refractive values after lens-sparing vitrectomy in proliferative diabetic retinopathy. The findings are consistent with the concept that SAM of mitral leaflets is due to anterior malposition of slack mitral leaflet portions into the LVOT. Diarrhea caused by multidrug-resistant bacteria is an important public health problem among children in developing countries. The increased expression of P-Erk1/2 in the corpus cavernosum may be involved in the development of ED in castrated rats. Left ventricular dysfunction (LVD) is a complex, multifactorial condition, caused by mechanical, neurohormonal, and genetic factors. Use of a robust dehydrogenase from an archael hyperthermophile in asymmetric catalysis-dynamic reductive kinetic resolution entry into (S)-profens.

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Vitamin D deficiency is associated with significant increases in the incidence of cardiovascular risk factors and mortality. Interventricular septal thickening in babies of diabetic mothers disrupt the diastolic function of both ventricles. Adult patients who had been diagnosed with smear-positive PTB at a primary care clinic or at the referral hospital and who were being treated at any of the three clinics were interviewed. This is a prospective cohort study involving a historical comparison (before and after the implementation of the protocol) of patients who had been hospitalized with severe sepsis and is bactrim a sulfonamide antibiotic septic shock. Profile of guanfacine extended release and its potential in the treatment of attention-deficit hyperactivity disorder. Because nitric oxide suppresses cell growth and can be metabolized to mutagens and carcinogens, the ability of benzene and its metabolites to modulates its production in the bone marrow may be important in their mechanism of action. Furthermore we give evidence for the specificity of action of AC on hormone release, since gonadotropin secretion remained unaffected. Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity. In addition, the evolutionary history of ST gene duplications indicated that the ST genes have experienced significant expansion in the whole ST gene family after the second WGD, especially after apple and pear divergence. Around one in six couples wishing to have children have problems conceiving, and in a fifth of these, the cause is identified as an ovulatory disorder.

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