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Alpam (Alprazolam)

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Alprazolam, available under the trade name Xanax, is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder, but also in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Alpam, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Alpam is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Aaram, Aleez, Alpanol, Alprawin, Alprosym, Alprotame, Andep, Anxicalm, Anxico, Anxit, Anxyl, Azoslip, Cardilax, Emlol, Finezol, Niravam, Ozolam, Paxor, Prazolam, Procalm, Rescalm, Riolam, Romipraz, Samprex, Silam, Sinaday, Sinzolam, Somnirest, Tenfree, Tenil, Zopain

Similar Products:
Colospa, Neoral, Norvasc, Caverta, Casodex

Also known as: Alprazolam


{name} (alprazolam) is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). It is thought that alprazolam works by enhancing the activity of certain neurotransmitters in the brain.

{name} is used to treat anxiety disorders and anxiety caused by depression.

{name} is also used to treat panic disorders with or without a fear of places and situations that might cause panic, helplessness, or embarrassment (agoraphobia).

It is dangerous to purchase {name} on the Internet or outside the United States. The sale and distribution of medicines outside the U.S. does not comply with safe-use regulations of the Food and Drug Administration (FDA). These medications may contain dangerous ingredients, or may not be distributed by a licensed pharmacy.


This section provides information on the proper use of a number of products that contain alprazolam. It may not be specific to Alpam XR. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is used for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the extended-release tablet or tablet whole with a full glass of water. Do not break, crush, or chew it.

If you are using the orally disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not remove the tablets from the bottle until you are ready to take it. Place the tablet immediately on the top of your tongue. It should melt quickly and be swallowed with saliva.

If you are using the oral liquid, measure the dose with a marked measuring spoon, oral syringe, or medicine cup.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For anxiety: For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.25 to 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 4 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For panic disorder: For oral dosage form (extended-release tablets): Adults—At first, 0.5 to 1 milligram (mg) taken in the morning once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.5 mg taken in the morning once a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention if you think you have used too much of this medicine. An overdose of Alpam XR can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, fainting, and coma.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details.

Side effects

The most common side effects associated with Alpam are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: kava, sodium oxybate.Other medications can affect the removal of Alpam from your body, which may affect how Alpam works. Examples include azole antifungals (such as itraconazole, ketoconazole), cimetidine, certain anti-depressants (such as fluoxetine, fluvoxamine, nefazodone), drugs to treat HIV (delavirdine, protease inhibitors such as indinavir), macrolide antibiotics (such as erythromycin), rifamycins (such as rifabutin), St. John's wort, drugs used to treat seizures (such as carbamazepine, phenytoin), among others.Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (such as diphenhydramine), medicine for sleep or anxiety (such as diazepam, zolpidem), muscle relaxants, narcotic pain relievers (such as codeine), psychiatric medicines (such as chlorpromazine, risperidone, amitriptyline, trazodone).Check the labels on all your medicines (such as cough-and-cold products) because they may contain ingredients which cause drowsiness. Ask your pharmacist about the safe use of those products.Cigarette smoking decreases blood levels of this medication. Tell your doctor if you smoke or if you have recently stopped smoking.

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Spinal mobility and its impact in Moroccan patients with ankylosing spondylitis. Thoracic surgical patients have chest drains inserted to enable re-expansion of lungs, to clear contents from the pleural cavity which sometimes require negative suction. The portability and compactness of this system enables short-term and potential long-term experimentation inside a conventional incubator. Furthermore, the change of the motion (V and D) and deformation (S and SR) in the course of the pregnancy was analyzed. The phospholipase activity detected by the PLA1 substrate could be inhibited with the small molecule esterase inhibitor ebelactone B. Recently, positive contrast techniques have been proposed, such as susceptibility gradient mapping (SGM). A generic coalescent-based framework for the selection of a reference panel for imputation.

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The first type interacted with native recombinant dN-GAPDS as well as with native human sperm-specific glyceraldehyde-3-phosphate dehydrogenase, not cross-reacting with muscle glyceraldehyde-3-phosphate dehydrogenase (GAPD). Ongoing audit and monitoring of service delivery will ensure a high standard of care is maintained. To evaluate the neuroprotective activity of hydroalcoholic extract of P. Analysis of 23 OCPs was performed using dual-column gas chromatography with electron-capture detectors. The efficacy of ECP in the treatment of chronic GvHD in paediatric patients after haematopoietic stem cell transplantation based on RCTs can currently not be evaluated since we have found no such studies. The objective of the present study is to determine the efficacy of vagus nerve stimulation therapy in patients with intractable epilepsy who have failed surgical and medical therapy. New advances in the biomechanics and pathomechanics of distal radius fractures as well as new generations of plates and improved surgical approaches now make possible the stable management and early functional rehabilitation not only of simple but also of complicated distal radius fractures according to the principles for articular and juxta-articular fractures.

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The second purpose was to analyze the relationships between the CPAQ and other important measures of pain adjustment. Development and pilot testing of the collaborative practice assessment tool. With optimized kinetic parameters, our theory produces a quantitative account of the measured time-dependent carbon adatom density. An alternative procedure is also proposed, in which the natural attached/free-living ratio is altered by an intervention experiment, allowing an estimation which is less model dependent but more labor intensive. Further details on a new method for quantitative erythrocyte determination. The aggregation rate of beta-GA in lyophilized formulations unexpectedly correlated with the local mobility of beta-GA, as indicated by T(1rho), rather than with (T-T(g)).

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We found that the activation of metabotropic glutamate receptors, via endogenous neurotransmitter or by agonist, causes long-term reduction of electrical synapse strength between the inhibitory neurons of the rat thalamic reticular nucleus. The objective of this review was to systematically evaluate and summarize the available evidence investigating the effect of PA on the survival of individuals with cancer. Overexpression of SOCS3 was found to reduce the level of calcium ionophore-induced phosphorylation of ERK1/2 and c-Jun transcription factor. Experience of prophylactic thyroidectomy in multiple endocrine neoplasia type 2A kindreds with RET codon 804 mutations. The Floxopatch mouse line is a useful tool for fast and sensitive characterization of neural activity in genetically specified cell types in intact tissue.

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Several studies suggest that histologic findings from tissues obtained at revision arthroplasty for failed metal-on-metal (MOM) total hip implants may reflect an immune reaction to particles or ions in some patients. Of the patients treated definitively, 4 had clinical stage T2A-T2C and 1 had clinical stage T1B. Can cyanobacterial biomass applied to soil affect survival and reproduction of springtail Folsomia candida?. Project meeting notes, PN activity logs and debriefings, physician interviews, and patient/family member interviews were analyzed using a grounded approach. Fh1 mutants developed multiple clonal renal cysts that overexpressed Hif1alpha and Hif2alpha. The histopathological diagnosis was mixed squamous cell and glandular papilloma. The majority of studies indicated a negative correlation between the expression of OCT4 and prognosis, and only in testicular germ cell tumor this correlation was positive. Survey questions were drawn and adapted from published studies and national surveys. The fundus images were classified as described in the Rotterdam Study and were graded independently by two experienced ophthalmologists (CK and UBK) based on the presence of hard and soft drusen, retinal pigmentary abnormalities, and signs of atrophic or neovascular age-related macular generation (AMD).

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The importance of social factors in the hospitalization of children. Response evaluation with 18FDG-PET has been shown to accurately assess the pathological response and also to predict the risk of local recurrence and overall survival. Inclusion criteria were the presence of unilateral or bilateral CIA aneurysm (independently from its diameter), IIA artery measuring up to 9 mm in its maximum diameter, not dilatation of IIA and EIA. The spontaneous resolution of pseudopancreatic cyst due to internal fistulization into the duodenum in a 4-year-old male child is described here. In 2001, The American Association of Immunologists Committee on the Status of Women conducted a survey examining the percentage of women faculty members within immunology departments or women in immunology graduate programs across 27 institutions in the United States, comparing it to the percentage of women receiving a Ph.D. The pore size and periodicity of sCOFs are tunable by employing diamine monomers with different lengths. The efficacy of two different lipid-based amphotericin B in neonatal Candida septicemia. Serotypes and Antimicrobial Susceptibility of Pasteurella multocida Isolated from Cattle and Pigs in Ontario. Polymorphic variation in glutathione-S-transferase genes and risk of chronic myeloid leukaemia in the Kashmiri population.

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Data were collected up to August 2010 from our prospective penile network database since its inception in 2005. Theileria electrophorin.sp., a parasite of the electric eel Electrophorus electricus (Osteichthyes: Cypriniformes: Gymnotidae) from Amazonian Brazil. A randomized, open-label, parallel-group comparative 28-day study was designed for 67 patients who were randomized into three treatment groups. Careful consideration of sequence processing methods and community analyses are warranted when testing hypotheses using read abundance data. Fractionation and comparison of the lipids of human strains of Mycobacterium tuberculosis by means of their infrared spectrums. In certain specialized applications, such as rotating-field NMR and mobile ex situ NMR, permanent magnet-based shimming systems can provide considerable advantages. In the excised root tips local auxin biosynthesis either alone or in cooperation with the reverse fountain enables RAM maintenance. A third myth, one currently in vogue among media pundits and politicians, is that health care and jobs are two separate issues and policymakers can deal with them as unrelated to each other, when in reality they are inextricably interwoven--the connective tissue of a physically and mentally robust workforce. We discuss diagnosis findings and interest in the surgical resection. Ostensibly, a dilemma has arisen whether the implant should obviate the necessity to preserve teeth with debatable restorative prognosis.

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Adrenergic activity accompanies intense exercise and mediates physiological and metabolic responses to exercise. Effects of sodium butyrate on proliferation of human oral squamous carcinoma cell line and expression of p27Kip1. We are considering the diagnostic algorithm before an isolated and atypical neurological presentation and reviewing the main neurological manifestations in lupus-like and autoimmune systemic disease. The optical excitation leads to a localized heating of the arrays, which in turn gives rise to a local change in conductance and a redistribution of the overall electrical potential in the arrays. The synthesis, photophysical and laser properties of a difluoro-boron-triaza-anthracene (BTAA) compound are analyzed in the present paper. RNA-sequencing analyses utilizing dG9a null mutant flies revealed that the expression of some genes relating to gustatory perception are regulated by dG9a under starvation conditions. The MRSA-colonised healthcare workers received intranasal mupirocin. Patients followed a FES-cycling treatment for 30 minutes a day, 3 days a week for 7 weeks. Application of molecular markers help estimate genetic diversity much more accurately than that of morphological traits. Non-syndromic multiple supernumerary teeth in a family unit with a normal karyotype: case report.

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Gefitinib versus docetaxel in previously treated advanced non-small-cell lung cancer: a meta-analysis of randomized controlled trials. Volume changes across the lung and transvascular fluid fluxes were calculated from changes in haemoglobin, packed cell volume, plasma protein and cardiac output (Q). Results from this study indicate that the order of increasing resistance to alkaline hydrolysis is TNT, DNT and DNAN. Recurrent hemichorea-hemiballism with non-ketotic hyperglycemia. This will require a functional disease surveillance system with adequate laboratory support throughout India. Upon inhibition or knockdown of PKCdelta, StxB molecules colocalized less with giantin and more with EEA1, indicating that the molecules were accumulated in endosomes, unable to reach the Golgi complex. Influenza B viruses cause annual outbreaks of respiratory illness in humans and are increasingly recognized as a major cause of influenza-associated pediatric mortality. Silicon/Mesoporous Carbon/Crystalline TiO2 Nanoparticles for Highly Stable Lithium Storage. The results indicate that the in vivo contact pressures in each TKA are greater for the medial condyle than for the lateral condyle. Hookworm infections are significant public health issues in South-East Asia.

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In this retrospective case study of the frequency and extension of aAL and cAL, the authors evaluated 1,384 mandibular sites in 694 CBCT scans of dentate and partly edentulous patients, performed mainly for further diagnosis before removal of the mandibular third molars between January 2009 and February 2013, by using multiplanar reconstructions. Plasmonic nanoantennas permit many functional components for future generations of nanoscale optical devices. Results do not provide support for the stress-vulnerability hypothesis and suggest that loss and CVRFs are independent predictors of depression, whose effects vary with the passage of time. There are several approaches for forming cardiac tissues, non-jet-based and jet-based methodologies. Multiple nodular cutaneous metastases as the first clinical sign of signet ring cell gastric carcinoma: case report.

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Giant intracranial aneurysm of the anterior communicating artery treated by direct surgery using A3-A3 side-to-side anastomosis and A3-RA graft-STA anastomosis. To study the clinicopathologic and immunohistochemical features, biological behavior, diagnosis and treatment of solid pseudopapillary tumor of the pancreas (SPTP). This review will focus on the new frontier defined by the experimental use of RGPs to study ROS signaling. The pregnancy outcome of women with factor V Leiden mutation was compared to those without congenital thrombophilia. Pediatric antiretroviral treatment coverage in resource-limited settings continues to lag behind adults. sPLA(2)-II favors the formation of bioactive lipids, stimulates SMC proliferation, activates macrophages enhancing lipid core formation and cytokine secretion, and binds to proteoglycans in the vessel wall matrix promoting lipid fusion and accumulation. Penile inversion vaginoplasty is considered the gold standard for vaginal construction in transgender women. We evaluated a large population dataset of bichorionic twins after exclusion of potential confounders and after controlling for parity and gestational age. Visibility can be improved in SILS using a PVC without leaving apparent scars.

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Restoration of ribozyme tertiary contact and function using a molecular glue for RNA. This study demonstrates that add-on therapy with montelukast plus low-dose budesonide is what is the maximum dose of plavix more effective than the addition of long-acting beta-agonists or doubling the dose of budesonide for controlling FENO in asthmatic children. The etiology of cardiovascular disease in diabetes may be divided into hyperglycemia per se and factors operating through components of metabolic syndrome (MetS). Physical examination, radiographs, and magnetic resonance imaging were performed during postoperative follow-up. Both lines had good agronomic characteristics and flowering habits, a high outcrossing rate, obvious fertility alterations and good combining abilities. Our earlier studies have shown that a voltage controlled capacitive discharge (VCCD) method of stimulation of nerve activation is able to selectively recruit activity in large myelinated nerve fibers. To enhance the partitioning of a given space, a residual version of the PC-tree algorithm is developed, denoted here as the principal component analysis tree (PCR-tree) algorithm. Efficient regeneration by activation of neurogenesis in homeostatically quiescent regions of the adult vertebrate brain. While these devices currently lack standardization and outcomes measures which establish clear clinical utility, their promise remains great, particularly in the potential to simulate the microenvironment of arteries vs. In conclusion, the inhibition of LDH could enhance anticancer activity of sorafenib, imatinib and sunitinib without increasing their side effects on normal cells, which in conditions of normal functional activity and sufficient oxygen supply do not need the activity of this enzyme.

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Using the data of patients with colon cancer from one English, one German, and two Japanese centers, the characteristics of clinicopathologic features were compared. The role of body mass index in survival outcome for lymphoma patients: US intergroup experience. A hazard ratio of each putative risk factor for IOP elevation was calculated using the Cox proportional hazard model for all participants, incorporating underlying disease as a covariate, as well as for each cohort. Procedures were categorized as arthroscopic Bankart repair, open Bankart repair, Bristow-Latarjet procedure, and other open procedures. Although recent vertebrate studies have revealed that different spinal networks are recruited in locomotor mode- and speed-dependent manners, it is unknown whether humans share similar neural mechanisms. Antioxidants in the egg yolk of a wild passerine: differences between breeding seasons. Giant traumatic popliteal artery (PA) pseudoaneurysms (PSA) are rare but limb threatening if untreated. We have constructed HIV-1 Gag cleavage site mutants to enable the steady state observation of virion maturation steps, and precisely study Gag processing, RNA dimerization, virion morphology and infectivity.

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