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Alpra (Alprazolam)
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Alpra

Alprazolam, available under the trade name Xanax, is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder, but also in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Alpra, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Alpra is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Aderta, Albiz, Allam, Alpradol, Alpranex, Alprasan, Alprastan, Alprazan, Alprogard, Alpron, Alpronit, Alsert, Altalin, Altok, Altrex, Alzom, Anxigo, Anxigon, Anxitab, Cooltime, Cqlam, Depwell, Dizeral, Elflu, Endolam, Finezol, Golprax, Hipose, Imprax, Mediprex, Pifzot, Prazil, Prolam, Selamb, Sertakem, Setlan, Tenrid, Tranax, Ziety, Zocam, Zolar, Zoldac, Zolran, Zoltweet, Zorest, Zotin

Similar Products:
Detrol, Lopressor, Prometrium, Zetia, Maxalt

Also known as: Alprazolam

Description

Alprazolam is used to relieve symptoms of anxiety, including anxiety caused by depression. It is also used to treat panic disorder in some patients.

Alprazolam is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system.

This medicine is available only with your doctor's prescription.

Dosage

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results.

Do not crush, chew, or break an extended-release tablet. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking the pill would cause too much of the drug to be released at one time.

Measure the liquid form of Alpra with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Do not swallow the orally disintegrating tablets whole. Allow it to dissolve in your mouth without chewing.

Contact your doctor if this medicine seems to stop working as well in treating your panic or anxiety symptoms.

You may have seizures or withdrawal symptoms when you stop using Alpra. Ask your doctor how to avoid withdrawal symptoms when you stop using Alpra.

Keep track of the amount of medicine used from each new bottle. Alpra is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Overdose

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of Alpra XR can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, fainting, and coma.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details.

Side effects

The most common side effects associated with Alpra are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.

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Meta-analysis: the placebo rate of abdominal pain remission in clinical trials of chronic pancreatitis. Coarse aggregates were typical of terminals of mossy fibers and climbing fibers. 2-Alkylsulfanyl-4(5)-aryl-5(4)-heteroarylimidazoles: An Overview on Synthetic Strategies and Biological Activity. The aim of our study was to describe the supplying arteries of the trapezium and the TM joint since this knowledge is essential for trapezium osteotomies. In contrast to TDP-43, no changes in subcellular distribution, no labeling of pathologic inclusions and no biochemical alterations were detectable for the tested hnRNPs and SMN in FTLD-U brains compared to controls. This study examined the longitudinal associations between stress, depressive symptoms, leisure satisfaction, and endothelial function as measured by FMD. NHANES should resume collecting audiometric data as part of their data collection protocol so that trends in the prevalence of childhood hearing loss can be documented. This study thus identifies Pitx2 as an upstream transcriptional regulator of atrial electric function, the insufficiency of which results in cellular and molecular changes leading to atrial electric and structural remodeling linked to arrhythmogenesis. Combined effect of bumetanide, bromide, and GABAergic agonists: an alternative treatment for intractable seizures. We also found that NBR1-independent bulk autophagy prevents premature plant death, thus extending the life span of virus reservoirs and particle production.

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Large-scale study of the interactions between proteins involved in type IV pilus biology in Neisseria meningitidis: characterization of a subcomplex involved in pilus assembly. These glacial forefield soils had significantly higher xyloglucan contents than detected in a UK grassland soil. We evaluated whether enhanced attention toward aversive stimuli, as indexed by an event-related potential component, the late positive potential (LPP), would predict response to cognitive behavioral therapy (CBT) in patients with social anxiety disorder and/or major depressive disorder. Some physical and chemical sand properties, the number of nests belong to both species and selected nest specifications were investigated in this study. However, mechanisms for functional regulation of C/EBPbeta remain uncharacterized. in an endemic area with a very low incidence of malaria in extra-Amazonian Brazil. Growth Kinetics of Thiobacillus ferrooxidans Isolated from Arsenic Mine Drainage.

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pylori and to attenuate the gastric inflammation caused by an H. Estradiol and progesterone strongly inhibit the innate immune response of mononuclear cells in newborns. Effect of arylamine acetyltransferase Nat3 gene knockout on N-acetylation in the mouse. A focally directed treatment strategy using fSRT with or without surgery appears to be an effective initial strategy. Demographic, work- and health-related factors, and back endurance were measured at baseline, while 14 monthly repeated text message assessments of LBP intensity were prospectively collected. The prospective studies showed that the S100B biomarker levels could be influenced by patient age and the time frame between head injury and blood sampling. 17 autosomal and Y STR loci were analyzed using AmpFlSTR Identifiler, PowerPlex 16, AmpFlSTR(R)Y-filertrade mark kits. Observations and results of the BCG vaccination with the Swiss BCG vaccine. However, few studies have systematically compared these different RNA-based markers. The cavity forms a three electrode section of a Penning-Malmberg trap and has a bulged cylindrical geometry with open ends aligned with the magnetic trapping axis.

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Various studies examined the relationship between VEGF overexpression with the clinical outcome in patients with hepatocellular carcinoma (HCC), but yielded conflicting results. We measured anti-natalizumab antibodies in a large cohort of 4881 unselected patients from four MS centres that systematically measured antibodies in patients treated with natalizumab. Prospective evaluation of an anaphylaxis education mini-handout: the AAAAI Anaphylaxis Wallet Card. The closed macular holes were categorized into two patterns based on optical coherence tomography: flat/closed and flat/open. The effect of sodium bicarbonate on acid-base balance in metabolic acidosis is interpreted differently by Henderson-Hasselbalch and strong ion acid-base approaches. Moreover, cells with aberrant chromatin morphology were found after treatment with the JNK inhibitor. Here, following error-prone polymerase chain reaction of the RTA open reading frame, we have used a modified gap-repair protocol in Saccharomyces cerevisiae to show that it is possible to rapidly generate a panel of inactive RTA mutants. Graft versus host disease in a pediatric multiple organ transplant recipient with trichohepatoenteric syndrome - a unique case report. The influences of different concentrations of As, Ben and Carb upon the endometrium were compared. Arabidopsis noncoding RNA modulates seedling greening during deetiolation.

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A total of 2206 genes were up-regulated and 1398 were down-regulated in infected plants, with an overrepresentation of genes involved in hormone metabolism and responses, nucleic acid metabolism, regulation of transcription, ubiquitin-proteasome pathway and autophagy among those up-regulated, and in primary and secondary metabolism, phosphorylation, transcription and methylation-dependent chromatin silencing among those down-regulated. High-throughput epidemiology: combining existing data from the Nordic countries in health-related collaborative research. Such patients often present to rheumatologists with rheumatologic symptoms and awareness of the disease is necessary to make the proper diagnosis. These modified metabolites included glutamate, acetylcholine, tryptamine, glucose, lactate, creatine, 3-hydroxybutyrate and nicotinamide-adenine dinucleotide (NAD), which was closely associated with neurotransmitter and energy source. Cancer systems biology: exploring cancer-associated genes on cellular networks. We describe a patient with follicular carcinoma submitted to total thyroidectomy. These results indicate that severe semen abnormality may be a risk factor in developing testicular cancers. The magnitude of angle SN-C axis is closely associated with vertical growth patterns and is weakly influenced by maxillofacial growth and development. This report contends that the preclinical evaluation of NXY-059 lacked strenuous testing and was not shown to reproducibly lead to robust protection in extended time windows in clinically relevant stroke models, at several different academic research laboratories. In this analytical cross sectional survey 83 children with ASD age range from 8 to 18 years were selected through convenient sampling technique from five special schools of Lahore city.

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This paper proposes a finite-element neural network (FENN) obtained by embedding a finite-element model in a neural network architecture that enables fast and accurate solution of the forward problem. Only a limited number of studies have studied the relationship between vitiligo and psychiatric morbidity and quality of life (QOL) in children and adolescents. To conclude, this work offers a new perspective for understanding the role of CIs and the presence of metabolic homeostasis in the living cell. This study analysed data from 7112 subjects, aged 30 years or over, who participated in the nationally representative Finnish Health 2000 Survey. Topical ophthalmic lipid nanoparticle formulations (SLN, NLC) of indomethacin for delivery to the posterior segment ocular tissues. The present case report illustrates an atypical electrocardiographic presentation of typical atrioventricular nodal re-entrant tachycardia. Ion channels are characterized by inherently stochastic behavior which can be represented by continuous-time Markov models (CTMM). The role of hypoxia-inducible factor family (HIF) proteins in the regulation of cells physiologic responses to hypoxia. In this study, we observed that clitocine can effectively induce drug-resistant human cancer cell apoptosis in vitro and inhibit tumor xenograft growth in vivo.

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C57bl/6J wildtype (WT) and CD11b/CD18 knock-out (CD11b(-/-)) mice were treated for 14 days with subcutaneous infusion of angiotensin II (Ang II), a known stimulus for PMN activation. The assembly successfully focused the intensity of a white beam of cold neutrons of one spin state at the detector, while defocusing the other. Modulation of P3 latency related to stimulus complexity could provide valuable information about the cognitive capabilities of unresponsive patients. Prevention of acute allergic and febrile reactions to blood transfusions by prophylactic use of an antihistamine plus an antipyretic. As a mechanistic approach, we looked at the role of the cannabinergic system which is linked to depression and/or antidepressant effect and appears to interact with neurotrophin signaling. Which is the best catheter to perform atrial fibrillation ablation?.

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Simulation approaches, on the other hand, can access the thermodynamics that contribute to the nanorod distribution and hence offer valuable aide upon the design and manufacture of the materials. The purpose of this study was to identify the underlying genetic mechanisms of a large autosomal dominant Caucasian family with omphalocele. Primary myocardial involvement in systemic sclerosis: evidence for a microvascular origin. Total anomalous pulmonary venous connection (TAPVC) with direct connection of the pulmonary veins to the morphologically right atrium is exceedingly rare other than in the setting of isomerism of the right atrial appendages. Functional analysis of a mitochondrial phosphopantetheinyl transferase (PPTase) gene pptB in Aspergillus fumigatus. Scores on the Hamilton Anxiety Rating Scale (HAM-A), Clinical Global Impression-Severity Scale (CGI-S), and Beck Anxiety Inventory (BAI) were evaluated. Our working hypothesis is that constant inter-pulse interval (IPI) electrical stimulation (ES) would resonate with endogenous epileptogenic reverberating circuits, favoring seizure, while random inter-interval ES protocol would promote desynchronization of such neural networks, interfering with the abnormal recruitment of neural structures. Aimed to compare the outcome in patients with acute low-tone sensorineural hearing loss (ALHL) treated with different doses of glucocorticoids. An unusual and potentially misleading phenotypic change in a primary gastrointestinal stromal tumour (GIST) under imatinib mesylate therapy.

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To establish a pre-column derivatization HPLC method for quantitation of hydroxyproline (Hyp) in rat kidney tissue by reversed-phase assay. To assess the diagnostic performance of a test based on cytogenetic abnormalities to diagnose, stage, and grade BUC from the urine. The study was designed to assess the C-IMT in patients with hypertension (HT) with or without HU. This study evaluated the complications associated with lung cancer surgery and anesthesia in underweight patients in a comparison with obese ones. Adequate intake of calories, protein, and micronutrients via frequent small meals and evening supplements and/or enteral and parenteral nutrition when indicated has been associated with reduced mortality and morbidity in patients with ALD. Reliability and preliminary evidence of validity of a Farsi version of the depression anxiety stress scales. Within a large flock of turkey toms (2000 BUT9 conventionally reared and slaughtered), early muscle pH measurements were randomly done to distinguish two groups of birds presenting low (fast glycolysing, GR) or normal (normal glycolysing, GN) values. I(F) and HOMA were statistically significantly related to BMI, WC, skinfold sum, WHtR, WHR and FM. As a result of current technologies, scientists have mastered several techniques for generating genetically modified animals. Cryo-electron tomography: methodology, developments and biological applications.

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Information from the baseline questionnaire filled out upon enrollment was used in this cross-sectional analysis on predictors of ANM onset. The relationship between traffic-related air pollutants and cardiac autonomic function in a panel of healthy adults: a further analysis with existing data. Extranodal lymphoma, secondary to or accompanying nodal disease is uncommon, but not unusual finding. Apoptosis is regulated in an orderly fashion by a series of genes, and has a crucial role in important physiological processes such as growth development, immunological response and so on. Comparison of iatrogenic articular cartilage injury in canine stifle arthroscopy versus medial parapatellar mini-arthrotomy in a cadaveric model.

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In addition a fragment of Nup153 encompassing the four tandem zinc fingers was found to bind Ran with similar affinity. local generation of thrombin-cleaved OPN was increased with greater OA severity. Intelligent robust control for uncertain nonlinear time-varying systems and its application to robotic systems. Unusual endocervical adenocarcinomas: an immunohistochemical analysis with molecular detection of human papillomavirus. Clinical and biological characteristics of childhood acute myeloid leukemia with EVI1 gene positive expression. Rebound macular edema following bevacizumab (Avastin) therapy for retinal venous occlusive disease.

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We have found an upward trend in the proportion of patients receiving both chemotherapy and radiotherapy which corresponded to a better survival in this group, but as flutamide 125 mg it only applied for a small proportion of patients, it was not enough to change the overall survival. Evaluation of molecular methods for detection of Borrelia burgdorferi senso lato in ticks. Besides the functional and radiological results, the potential surgical risks and the observed complications are discussed. Stability pad balance training reduces the incidence of noncontact inversion ankle sprains in football players with increased risk. Renal involvement in DN has been widely studied and different pathological classifications have been proposed. Molecular imaging metrics to evaluate response to preclinical therapeutic regimens.

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The risk of the disease is dependent on complex interactions between host genetics and environmental factors. Subsequently, all such sites were classified using various computational methods based on sequence similarity to identify multiple subtypes. All patients what type of drug is evista were operated on via a median sternotomy and a left atrial approach. A mock circulatory system with physiological distribution of terminal resistance and compliance: application for testing the intra-aortic balloon pump. Attempts to broaden the reach, quicken the uptake, and facilitate the use of cancer communication innovations can apply design activities to increase the likelihood of diffusion. The specific sensitivity of NMA and INM allows one to identify equilibrium configurations in this nonequilibrium environment for these finite clusters. We report the case of a kidney transplant recipient with invasive aspergillosis due to Aspergillus fumigatus resistant to voriconazole and intermediately susceptible to posaconazole who failed posaconazole therapy.

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Secondary procedures included flap debulking (5) and Z-plasties (2). To systematically review evidence on clinical effectiveness and safety of acupuncture in irradiation-induced xerostomia in patients with HNC. In contrast, 2-dimethylsulfonioacetate (DMSA), the sulfonium analog of the universal osmoprotectant glycine betaine (GB), was highly toxic to unstressed cells and was not osmoprotective fulvicin medication in stressed cells of wild-type strains of S. Artificial ventilation was carried out using a tracheotomy tube, and a laser fiber was inserted orally for tumor ablation. Mixed-mode pattern in Doublefoot mutant mouse limb--Turing reaction-diffusion model on a growing domain during limb development. Macrolides are used to treat pneumonia despite increasing antimicrobial resistance. Paraffin sections of tumors were immunohistochemically stained for p53 and Ki67 expression.

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Referrals are notoriously difficult to track and review due to poor quality of written paper-based recorded information for handover (illegibility, incomplete paper trail, repetition of information and loss of patients). Human muscle protein synthesis after physical activity and feeding. This led the way for a conservative approach via laparoscopy of untwisting the pedicle to restore blood flow In this case, the ovarian ligament was shorted using 1/0 vicryl and the pregnancy went to term. Measuring and quantifying acute exacerbations of COPD: pitfalls and practicalities. ACCF with anterior plate fixation is a reliable and effective method for treating CSM in terms of JOA score and the recovery rate. Primary sources and secondary formation of organic aerosols in Beijing, China. This population-based study documented changes in workload and treatment complexity over a 10 year period in a Canadian province. However, complete aneurysm occlusion with preservation of the PcomA can be difficult in case of wide-neck aneurysms with a PcomA incorporation. However, Irgel had better effects on wound healing and pain relief than MaxGel, which indicates a better quality of Irgel for this particular kind of treatment. Patients randomly underwent LTD4 and histamine nasal challenge tests, completed the rhinoconjunctivitis quality of life questionnaire (RQoLQ), and rating the symptom severity score (total symptom score 4, TSS4) in the previous week.

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These findings suggest that mechanical barriers act downstream of EphA/ephrin signaling to segregate cells from different rhombomeres. Elsewhere, PET imaging has been discussed at length, because it is likely to be superior in the assessment of bone and soft tissue tumours over conventional nuclear medicine procedures. Additionally, a suppression in reactive oxygen species was observed. We report a case with initial clinical, radiological and serological features consistent with NMO, but with concomitant extensively clinical and radiological involvement of the brain stem. Using sea urchin eggs and early embryos, two isoforms of eEF2 of respectively 80 and 83 kDa apparent molecular weight have been discovered. Increased plasma homocysteine has been linked to many clinical conditions including atherosclerosis and ischemic stroke.

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The image subtraction technique also facilitates quantitative and qualitative evaluation of adrenal masses in chemical shift MRI. Can the import of mRNA into chloroplasts be mediated by a secondary structure of a small non-coding RNA?. Such information should motivate floxin drops dosage the discovery and development of novel GAG analogues as new therapeutics for Lyme disease. SpyCatcher has 320-fold specificity for its native SpyTag compared to SdyTag. Lower levels of proinflammatory cytokines in CBMC, used to model a state of minimal immune activation and immature immunity, than in PBMC were associated with lytic EBV infection. In contrast, transcripts for cx34.3 and cx43.2 were low at the PN-stage and increased during later stages of oogenesis, peaking at the mid vitellogenic (VIT)-stage and maturing (MAT)-stage, respectively.

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The neutrophil-lymphocyte ratio (NLR) is a recognized marker of inflammation associated with poor outcomes in various clinical situations. Satisfactory convergent and discriminant validity were demonstrated with the multitrait-multimethod technique. Most participating laboratories could detect influenza virus growth and could identify virus amplified from EQA samples. One dog developed status epilepticus, the recordings of which were also investigated. This review discusses the history and development of coupling reactions between aryl halides and various classes of nucleophiles, focusing mostly on the different mechanisms proposed through the years. Compare adverse events (AEs) in patients with epilepsy taking different antiepileptic drugs (AEDs) using standardized physician-completed questionnaires.

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Resistance concerns are likely insufficient to rule out use of continuous IPT when coupled with effective TB treatment, case finding, and HIV control. Here, we present a detailed analysis of ejaculate expenditure according to male roles in the bank vole (Myodes glareolus). In vitro, H1975 cells were sensitive to the third-generation epidermal growth factor receptor inhibitor osimertinib. Cognitive and affective deficits are prominent clinical features of schizophrenia that impact functioning and are a challenge to effective treatment. To evaluate the clinical effectiveness and safety of uterine artery embolization (UAE) in the treatment of primary postpartum hemorrhage (PPH), secondary PPH, and PPH associated with cesarean section. Spontaneous abortion is one of the most frequent problems of pregnancy, estimated to affect, at least, one in every four women who tries to conceive.

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This new area of interdisciplinary research holds the promise of developing new approaches to treating drug abuse and obesity. This flux appears to promote motion along potential gradients and can be utilized to enhance the sampling of ordered arrangements, i.e., it can facilitate the formation of a critical nucleus. Context and processes of care that could influence ventilator weaning outcomes varied considerably across countries. Knee osteoarthritis (OA) is a significant contributor to disability, and obesity is one of the most modifiable risk factors. Human rhinoviruses and severe respiratory infections: is it possible to identify at-risk patients early?. We describe black widow spider exposures and treatment in the pediatric age group, and investigate reasons for not using antivenom in severe cases. Recent studies have found that the human and mouse Swi5 and Sfr1 proteins form a complex that influences Rad51-mediated HR in cells. Home care today: showcasing interdisciplinary management in home care.

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