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Alrest (Clonazepam)

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Clonazepam, sold under the brand name Klonopin among others, is a medication used to prevent and treat seizures, panic disorder, and for the movement disorder known as akathisia. It is a tranquilizer of the benzodiazepine class. It is taken by mouth. It begins having an effect within an hour and lasts between six and 12 hours. Alrest was initially patented in 1964 and went on sale in the United States in 1975. It is available as a generic medication.

Other names for this medication:
Almac, Azpax, Catier, Cloam, Clodep, Clonapax, Clonasig, Clonatrac, Clonaxyl, Cloneepam, Clonix, Clonopam, Clonotril, Clopam, Clozep, Clozipam, Convaclon, Dipwell, Epcon, Epicloz, Epizam, Escimax, Estalonix, Ezinite, Jasoclam, Jbcloz, Klopam, Lonazep, Lonipax, Melzap, Norep, Petril, Repam, Revozip, Rivotril, Sezolan, Sezolep, Somnolex, Somnotril, Zolpidox

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Also known as: Clonazepam


{name} (clonazepam) is a benzodiazepine. It is thought that clonazepam works by enhancing the activity of certain neurotransmitters in the brain. Clonazepam is also a seizure medicine, also called an anti-epileptic drug.

{name} is used to treat certain seizure disorders (including absence seizures or Lennox-Gastaut syndrome in adults and children.

{name} is also used to treat panic disorder (including agoraphobia) in adults.


Adults. The initial dose for adults with seizure disorders should not exceed 1.5 mg/day divided into three doses. Dosage may be increased in increments of 0.5 to 1 mg every 3 days until seizures are adequately controlled or until side effects preclude any further increase. Maintenance dosage must be individualized for each patient depending upon response. Maximum recommended daily dose is 20 mg. The use of multiple anticonvulsants may result in an increase of depressant adverse effects. This should be considered before adding Alrest to an existing anticonvulsant regimen.

Pediatric Patients. Alrest is administered orally. In order to minimize drowsiness, the initial dose for infants and children (up to 10 years of age or 30 kg of body weight) should be between 0.01 and 0.03 mg/kg/day but not to exceed 0.05 mg/kg/day given in two or three divided doses. Dosage should be increased by no more than 0.25 to 0.5 mg every third day until a daily maintenance dose of 0.1 to 0.2 mg/kg of body weight has been reached, unless seizures are controlled or side effects preclude further increase. Whenever possible, the daily dose should be divided into three equal doses. If doses are not equally divided, the largest dose should be given before retiring.

Geriatric Patients. There is no clinical trial experience with Alrest in seizure disorder patients 65 years of age and older. In general, elderly patients should be started on low doses of Alrest and observed closely.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, or coma.


Store at 25 degrees C (77 degrees F); excursions permitted to 15 to 30 degrees C (59 to 86 degrees F).

Side effects

The most common side effects associated with Alrest are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


This medication may cause withdrawal reactions, especially if it has been used regularly for a long time or in high doses. In such cases, withdrawal symptoms (such as seizures, mental/mood changes, shaking, stomach/muscle cramps) may occur if you suddenly stop using this medication. To prevent withdrawal reactions, your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details, and report any withdrawal reactions right away.

When this medication is used for a long time, it may not work as well. Talk with your doctor if this medication stops working well.

Though it helps many people, this medication may sometimes cause addiction. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). Take this medication exactly as prescribed to lower the risk of addiction. Ask your doctor or pharmacist for more details.

If you have several different types of seizure disorders, you may experience a worsening of seizures when you first start using Alrest. Consult your doctor right away if this happens. Your doctor may need to add or adjust the dose of your other medications to control the seizures.

Tell your doctor if your condition persists or worsens.

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Retinal microglial cells of newborn Lewis rats were isolated and cultured, and the effect of macrophage colony-stimulating factor (M-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), and interferon-gamma (IFN-gamma) on microglial expression of the accessory molecules required for antigen presentation were studied. When the cantilever oscillation amplitude is large, its motion dominates the charge dynamics of the dot which in turn leads to nonlinear, amplitude-dependent damping of the cantilever. These species, generally absent in the milk, occur in dairy ecosystems and dominate the bacterial flora of many ripened semihard cheeses. These results showed that the Meixi River is a sink for atmospheric CO2, and the mainstream of the Three Gorges Reservoir is a source for atmospheric CO2. A convenience sample of 97 patients with benign prostatic hyperplasia was recruited at an outpatient urology clinic of a tertiary hospital in Singapore. Survival after an amniotic fluid embolism following the use of sodium bicarbonate.

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Laparoscopic repair of a diaphragmatic hernia through the right sternocostal foramen of Morgagni in an obese 42-year-old man is described. All novel fullerene derivatives showed potent human immunodeficiency virus-reverse transcriptase inhibition without cytotoxicity. Rats were assigned to receive dextromethorphan (0, 20 or 40 mg/kg) or dextrorphan (0, 15 or 30 mg/kg) combined with norpethidine (0, 28 or 42 mg/kg). Consequently, neutrophil-mediated clearance predominates in elimination of the drug. A photoacoustic cell has been developed in the form of an elliptical cylinder in which essentially all the acoustic energy generated by a laser beam passing down one axis is focused onto a cylindrical acoustic transducer located along the other axis. The procedure describes the delivery of PRV369 to the glands and shows how SMG neurons can then be imaged post-inoculation to explore connectivity and activity.

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Thermoresponsive poly(N-isopropyl acrylamide)-grafted polycaprolactone films with surface immobilization of collagen. Clinical features of Coats disease and consanguinity were also encountered. Previous studies have provided evidence for the presence of familial aggregation of periodontal pathogens and periodontitis and have alluded to possible transmissibility of these organisms within families. A change in the visual analog scale score represents a relative change in the magnitude of pain sensation. Major deficiencies in delivery of secondary prevention after stroke have been demonstrated. If so, mathematical models that are helpful in understanding the spread of infectious diseases may also help to understand the spread of certain behaviors. The preparation of some alpha-dialkylamino-omega-methylaminoalkanes. The Rh D blood group is determined by the RHD gene, which encodes a 12-transmembrane domain protein.

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Both the general and disease-specific comorbidity indices provided important prognostic information. Peer-Assisted Learning Activities During Undergraduate Ophthalmology Training: How the Medical Students of Asia Pacific Region Perceive. We show that the 5T4 glycoprotein is required for optimal functional cell surface expression of the chemokine receptor CXCR4 and CXCL12 mediated chemotaxis in differentiating murine embryonic stem cells and embryo fibroblasts (MEF). This clinical study was a prospective cross-sectional comparative trial that screened 1000 patients (aged 30-50 years) in a low-resource setting. The effect of involvement in a student-run free clinic project on attitudes toward the underserved and interest in primary care. Particularly, variables such as knee abduction moments and transverse plane knee motion have not been studied during a game-specific landing and cutting task after ACL reconstruction.

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We identified five components that were located within different parts of the thalamus and the basal ganglia. Although improvements are still needed, the advanced modeling and validation techniques used herein contribute toward improved and quantified accuracy over earlier simplified models. The current indications of OLT in TT1 are non-response to NTBC, risk of malignancy and poor quality of life related to dietary restriction and frequency of blood sampling. Although computer models have been extensively used in recent years to understand the way physical systems operate and interact, the enormous power of mathematical modeling and computer simulations has been difficult to implement for the benefit of neuroscientists studying the human motor control system. Though research has investigated the link between SEM and sexual risk behaviour, little has been published about preferences for characteristics of SEM. Neonatal stage IV and IVs neuroblastoma: surgical treatment with silo and liver reduction. In the present study, through a comprehensive analysis of bioactive substances, NT and LANT-6 were identified in the chicken brain using tandem mass spectrometry combined with a bioassay of the colon contraction. Live cell imaging revealed that the fragments were generated by microtubule detachment from centrosomes, a process that was reversed by paclitaxel. When rocaltrol tablet uses in hindi cervicitis was initially recognized as a clinical entity, several investigators reported the primary pathogens causing cervicitis as Neisseria gonorrhoeae and Chlamydia trachomatis.

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Experimental studies of thermal therapy for severe nonvariceal bleeding in dogs. Lipoprotein profile among very high risk patients during combined therapy lead to improvement and therefore may contribute to lowering of their residual risk. We here describe the basic principles of using nanomaterials for targeting therapeutic and diagnostic agents to pathological sites, and we discuss how nanotheranostics and image-guided drug delivery can be used to personalize nanomedicine treatments. The effect of using a shared electronic health record on quality of care in people with type 2 diabetes. We searched, by polymerase chain reaction (PCR), for VZV DNA in peripheral mononuclear cells of 82 patients with relapsing-remitting MS.

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Progression through mitosis is controlled by cyclin-dependent kinases, which drive cells into metaphase, and by the anaphase-promoting complex/cyclosome, a ubiquitin ligase that triggers sister chromatid separation and exit from mitosis. Twenty chronic patients with a diagnosis of schizophrenia were entered into a double-blind, randomized, placebo-controlled crossover study using a 200 mg dose of modafinil. Structural remodeling of resistance arteries in uremic hypertension. To assess the distribution of human leukocyte antigen (HLA)-DQ2 and -DQ8 in Iranian celiac disease (CD) patients and compare them to healthy Iranian controls. In this study N(2)O emissions were simulated for 1052 grassland sites in the United States using the NGAS model of Parton and others (1996) coupled with an organic matter decomposition model. We believe that carrying out periodic screening in schools in which especially low-income and parasite-infected children should be treated, informed about prevention and control methods. Mechanical properties of the extracellular matrix (ECM) are proposed to influence cell behavior and biological activity. The effectiveness of sublingual and topical compounded bioidentical hormone replacement therapy in postmenopausal women: an observational cohort study.

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