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Araten (Losartan)

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Araten is hypotension medication which specifically blocks angiotensin II receptors, decreases the total peripheral resistance, concentration of aldosteron in blood, arterial pressure, pressure in pulmonary circulation, and has a diuretic effect. The medication is used to treat hypertension, left ventricular hypertrophy (increase in muscle) and diabetic nephropathy.

Other names for this medication:
Angibloc, Angilock, Anreb, Asart, Cardon, Cartan, Eklips, Fensartan, Lepitrin, Loortan, Losacar, Losadrac, Losan, Losap, Losapot, Losapres, Losarb, Losartic, Losatan, Losazid, Losazide, Lostat, Lotan, Lozitan, Osartan, Rasertan, Rosatan, Zaart, Zartan

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Also known as: Losartan


Araten (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Araten is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Araten is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Araten 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Araten 25 mg, Araten 50 mg, and Araten 100 mg may also contain carnauba wax.


Take Araten tablets orally with or without food. Do not crush or chew it. Take Araten once or twice a day at the same time. If you want to achieve most effective results do not stop taking Araten suddenly.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Araten are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Changes in renal function including acute renal failure can be caused by drugs that inhibit the reninangiotensin system and by diuretics. Patients whose renal function may depend in part on the activity of the renin-angiotensin system (e.g., patients with renal artery stenosis, chronic kidney disease, severe congestive heart failure, or volume depletion) may be at particular risk of developing acute renal failure on COZAAR. Monitor renal function periodically in these patients. Consider withholding or discontinuing therapy in patients who develop a clinically significant decrease in renal function on Araten.

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The Cardiac Resynchronization-Heart Failure (CARE-HF) study helped establish an important role for cardiac resynchronization therapy (CRT) in the management of selected patients with heart failure. Histomorphology of the pharyngoesophageal sphincter as prognostic factor of developing esophageal speech. AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram). alpha-Amylase of Clostridium thermosulfurogenes EM1: nucleotide sequence of the gene, processing of the enzyme, and comparison of other alpha-amylases. The participants discussed their proposed issues in a moderated session and decided on the key future issues of health services research in a double voting procedure. Antiserum to chick skeletal muscle tropomyosin was used to localize tropomyosin in mouse embryo fibroblasts by the indirect fluorescein labeled antibody technique. Higher family support predicted decreasing weight across the first postpartum year, and higher family negativity predicted higher weight at 6 weeks postpartum and increasing weight across the first postpartum year. A novel granulation non-solvent addition method containing hydrophilic and lipophilic drugs.

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Effects of irradiation dose and O(2) and CO(2) concentrations in packages on foodborne pathogenic bacteria and quality of ready-to-cook seasoned ground beef product (meatball) during refrigerated storage. Computed tomograph, esophagoscopy, and esophagography revealed the fistulous communication between the mid-esophagus and right lower lobe bronchus, with consolidation in the right lower lobe. Pharmacokinetics of sulfadimidine after intravenous and oral administration of 50 mg per kg body weight were investigated in 2- to 22-day-old healthy and diarrheic calves. Extension of indications for portal shunt operation through the management of postoperative liver decompensation with peritoneal dialysis. Rab proteins and endocytic trafficking: potential targets for therapeutic intervention. This suppression of Bcrp S-S bond formation may be related to mitochondrial dysfunction. Side effects of this class of drugs require caution in cases of congestive heart failure and in asthmatics.

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Adjuvant radiotherapy improves lymph-node field control in patients at high risk of lymph-node field relapse after therapeutic lymphadenectomy for metastatic melanoma. We analyzed 262 ovarian cancer patients recruited from 27 hospitals in 12 provinces and Ha Noi City from April 2001 to May 2006, plus 755 controls matched by age and residential address. Physiologist Johannes Evangelista, Ritter von Purkinje (1787-1869). The enzyme GIBBERELLIN 2 OXIDASE 7 (GA2ox7), which catabolizes active GAs, was overexpressed in most tissues from the viral CaMV 35S promoter, specifically in the vascular tissue from the SUCROSE TRANSPORTER 2 (SUC2) promoter or in the shoot apical meristem from the KNAT1 promoter. Consequently, peripheral venous glucagon concentrations may not necessarily reflect concentrations of glucagon delivered to its target organ, the liver, via the portal vein. Posterolateral rotatory instability of the elbow: a case report and review of the related literature. This study compared the results of rotating-platform high-flexion (RP-F) total knee arthroplasty with low contact stress (LCS) for clinical and radiographical assessment after a short-term period. The implications for obtaining quantitative binding data by radioimmunoassay for natural antigens, which almost universally have more than one antigenic determinant on the same molecule, are discussed. Development of the National Norms of Negligence on children aged 0 to 35 months in rural areas of China.

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Halichondrin B did not interfere with colchicine binding to tubulin, but it was a noncompetitive inhibitor of the binding of vinblastine to tubulin (apparent Ki, 5.0 microM). Points covered are the locations of mitochondrial oxidant generation, characteristics of antioxidant systems in various mitochondrial compartments, and diffusion characteristics of oxidants in mitochondria. Cervical screening: a guideline for clinical practice in Ontario. Cytochrome P-450 dependent irreversible binding of 6-thiopurine to rat liver microsomal protein in vitro and protection by glutathione. Data from a total of 6962 upper gastrointestinal endoscopies over a five year period were retrospectively obtained and analysed. Main ED census records were divided into three distinct time frames: period A (control) was January 2007 through June 2007. Escherichia coli endotoxin was administered to streptozotocin-diabetic and control normoglycemic rats. To analyze the results of percutaneous cholecystostomy in in high-risk elderly patients with acute cholecystitis. Resection of intradural tumors is often followed by bending of the spinal cord within the surgical cave. Inhibitors of DNA methylation in the treatment of hematological malignancies and MDS.

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The enteric nervous system in inflammation and pain: the role of proteinase-activated receptors. Several preclinical and clinical studies have suggested that chronic disruption of the blood-brain barrier is one of the mechanisms for the development of cerebral microbleeds.A 51-year-old man experienced two left parieto-occipital lobar intracerebral haemorrhages (ICHs) in the timespan of 2 years. For example, the interpretation of kinetic data on substrate specificity was difficult when there was a significant kinetic contribution from the interfacial binding step to the steady-state catalytic turnover. In dogs, sporadic emesis was noted at 12.5 mg/kg and greater, and significant pathologic changes consisted of coronary arteritis associated with myocardial lesions and lymphocyte depletion at 25 and 50 mg/kg, pancreatic acinar necrosis at 50 mg/kg, and renal tubular degeneration at 12.5 mg/kg and greater. The trypsin-like and cathepsin C-like enzyme activities also showed 3 to 4-fold higher in Orientals than in Caucasians. The effect of chromium supplementation on serum lipids and glucose tolerance was tested in a double-blind 12-wk study of 23 healthy adult men aged 31 to 60 yr. On the presence of intracytoplasmic epithelium fibrils of the cells of the human conjunctiva. Percutaneous vertebroplasty is a widely used treatment for vertebral compression fracture. Survivors of critical illness commonly experience new or worsening IADL dependency that may improve over time.

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Inhibition of macrophage-Trypanosoma cruzi interaction by concanavalin A and differential binding of bloodstream and culture forms to the macrophage surface. Most residents receive little to no formal exposure to bioinformatics during medical education, and most of the pathology training is spent interpreting histopathology slides using light microscopy or focused on laboratory regulation, management, and interpretation of discrete laboratory data. The minimum concentrations of free carnitine and acylcarnitine in serum were invariably associated with the maximum concentration of drug in serum. Use of Phosphorus Binders among Non-Dialysis Chronic Kidney Disease Patients and Mortality Outcomes. Both odontoclasts and osteoclasts are rich in enzymes concerned with energy production and possess considerable activity of enzymes usually associated with catabolic functions. In the context of structural studies of PorM to better understand T9SS assembly, four camelid nanobodies were selected, produced and purified, and their specific interaction with the N-terminal or C-terminal part of the periplasmic domain of PorM was investigated. A 75-year-old woman with dementia presented with per rectal bleeding, rectal prolapse and lower abdominal pain. Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor ultram er cost for Mycobacterium tuberculosis.

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