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Aviglen (Glibenclamide)
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Aviglen

Aviglen is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Aviglen is in a class of medications called sulfonylureas.

Other names for this medication:
Aviglen, Benclamet, Combidos, Comdiab, Daocon, Diabetnil, Diabnil, Diolin, Duotrol, Dutrol, Euglucon, Eumet, Glibact, Glibenclamide, Glibet, Glime, Glimsug, Glinil, Glitrac, Glucomin, Glucored, Glucosafe, Glucosil, Glucotrac, Glybenclamide, Glybid, Glybovin, Glycurb, Glymep, Iscept, Metclam, Metica, Secrin, Sugatrol, Sugnil, Sycored, Symet

Similar Products:
Avodart, Ilosone, Anafranil, Coumadin, Dramamine, Priligy, Ovral, Zyrtec

Also known as: Glibenclamide

Description

Aviglen comes as a tablet to take by mouth. It is usually taken once a day with breakfast or the first main meal of the day. However, in some cases your doctor may tell you to take Aviglen twice a day. To help you remember to take Aviglen, take it at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Aviglen exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor will probably start you on a low dose of Aviglen and gradually increase your dose if needed. After you have taken Aviglen for some time, Aviglen may not control your blood sugar as well as it did at the beginning of your treatment. Your doctor may adjust the dose of your medication as needed so that the medication will work best for you. Be sure to tell your doctor how you are feeling and if your blood sugar test results have been higher or lower than normal at any time during your treatment.

Aviglen helps control blood sugar but does not cure diabetes. Continue to take Aviglen even if you feel well. Do not stop taking Aviglen without talking to your doctor.

Dosage

Usual Adult Dose for Diabetes Type 2:

Standard Aviglen: -Initial dose: 2.5 mg to 5 mg orally once a day -Dose titration: Increase in increments of no more than 2.5 mg at weekly intervals based upon blood glucose response -Maintenance dose: 1.25 to 20 mg orally as a single dose or in divided doses -Maximum dose: 20 mg/day Micronized Aviglen: -Initial dose: 1.5 mg to 3 mg orally once a day -Dose titration: Increase in increments of no more than 1.5 mg at weekly intervals based upon blood glucose response -Maintenance dose: 0.75 to 12 mg orally as a single dose or in divided doses -Maximum dose: 12 mg/day Comments: -Administer with breakfast or the first main meal of the day -Lower initial doses may be used in patients who are sensitive to hypoglycemic drugs -Once a day therapy is generally satisfactory, however, some patients may have a more satisfactory response with twice-a-day dosing, especially those receiving higher doses. TRANSFER FROM OTHER HYPOGLYCEMIC THERAPY: -Oral Antidiabetic Therapy: No exact dosage relationships exists between standard Aviglen, micronized Aviglen, or other oral hypoglycemic agents; when transferring patients from other oral hypoglycemic therapy, the maximum starting doses should be observed. -Insulin: --If the insulin dose is less than 20 units per day substitute 2.5 to 5 mg (standard) OR 1.5 to 3 mg (micronized) orally once a day. --If the insulin dose is between 20 and 40 units per day, substitute 5 mg (standard) OR 3 mg (micronized) orally once a day. --If the insulin dose is more than 40 units per day; transition the patient by concomitantly decreasing insulin by 50% and starting Aviglen at 5 mg (standard) OR 3 mg (micronized) orally once a day; as insulin is progressively withdrawn, titrate in increments of 1.25 to 2.5 mg (standard) OR 0.75 to 1.5 mg (micronized) orally once a day every 2 to 10 days. Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Usual Geriatric Dose for Diabetes Type 2:

Initial dose: 1.25 to 2.5 mg (standard) orally or 0.75 to 1.5 mg (micronized) orally once a day.

Detailed Aviglen dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can cause severe hypoglycemia or lactic acidosis.

Storage

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

Side effects

The most common side effects associated with Aviglen are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Before taking Aviglen,

  • tell your doctor and pharmacist if you are allergic to Aviglen, any other medications, or any of the ingredients in Aviglen. Ask your pharmacist for a list of the ingredients.
  • tell your doctor if you are taking bosentan (Tracleer). Your doctor may tell you not to take Aviglen if you are taking this medication.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril, (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik); anticoagulants ('blood thinners') such as warfarin (Coumadin); aspirin and other nonsteroidal anti-inflammatory medications (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); beta blockers such as atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal); calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac, others), felodipine (Plendil), isradipine (DynaCirc), nicardipine (Cardene), nifedipine (Adalat, Procardia), nimodipine (Nimotop), nisoldipine (Sular), and verapamil (Calan, Isoptin, Verelan); chloramphenicol; clarithromycin (Biaxin); cyclosporine (Neoral, Sandimmune); disopyramide (Norpace); diuretics ('water pills'); fluconazole (Diflucan), fluoxetine (Prozac, Sarafem); gemfibrozil (Lopid), hormone replacement therapy and hormonal contraceptives (birth control pills, patches, rings, implants, and injections); insulin or other medications to treat high blood sugar or diabetes; isoniazid (INH); MAO inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate); medications for asthma and colds; medications for mental illness and nausea; miconazole (Monistat); niacin; oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone); phenytoin (Dilantin); probenecid (Benemid); quinolone and fluoroquinolone antibiotics such as cinoxacin (Cinobac), ciprofloxacin (Cipro), enoxacin (Penetrex), gatifloxacin (Tequin), levofloxacin (Levaquin), lomefloxacin (Maxaquin), moxifloxacin (Avelox), nalidixic acid (NegGram), norfloxacin (Noroxin), ofloxacin (Floxin), sparfloxacin (Zagam), trovafloxacin and alatrofloxacin combination (Trovan); rifampin; salicylate pain relievers such as choline magnesium trisalicylate, choline salicylate (Arthropan), diflunisal (Dolobid), magnesium salicylate (Doan's, others), and salsalate (Argesic, Disalcid, Salgesic); sulfa antibiotics such as co-trimoxazole (Bactrim, Septra); sulfasalazine (Azulfidine); and thyroid medications. Also be sure to tell your doctor or pharmacist if you stop taking any medications while taking Aviglen. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have or have ever had G6PD deficiency (an inherited condition causing premature destruction of red blood cells or hemolytic anemia); if you have hormone disorders involving the adrenal, pituitary, or thyroid gland; or if you have heart, kidney, or liver disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking Aviglen, call your doctor.
  • talk to your doctor about the risks and benefits of taking Aviglen if you are 65 years of age or older. Older adults should not usually take Aviglen because it is not as safe or effective as other medications that can be used to treat the same condition.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking Aviglen.
  • ask your doctor about the safe use of alcoholic beverages while you are taking Aviglen. Alcohol can make the side effects from Aviglen worse. Consuming alcohol while taking Aviglen also rarely may cause symptoms such as flushing (reddening of the face), headache, nausea, vomiting, chest pain, weakness, blurred vision, mental confusion, sweating, choking, breathing difficulty, and anxiety.
  • plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Aviglen may make your skin sensitive to sunlight.
  • ask your doctor what to do if you get sick, develop an infection or fever, experience unusual stress, or are injured. These conditions can affect your blood sugar and the amount of Aviglen you may need.

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Integrality of nasalization and F1 in vowels in isolation and before oral and nasal consonants: a detection-theoretic application of the Garner paradigm. A 59-year-old Laotian male with a past medical history of multiple myeloma on peritoneal dialysis (PD) presented with abdominal pain and peritoneal eosinophilia. Phenylarsine oxide evokes intracellular calcium increases and amylase secretion in isolated rat pancreatic acinar cells. The assembly process is followed by IR and X-ray photoelectron spectroscopies to confirm the formation of a monolayer with bound catalyst. Pregnant women taking methadone should be warned about withdrawal symptoms in babies. Camptothecin derivative is becoming a hot point in the treatment of advanced NSCLC. The spectral domain of an ultraviolet femtosecond laser was expanded by stimulated Raman scattering/four-wave Raman mixing, and the resulting laser pulse was compressed using a pair of gratings. Lateral cross-fibres extended from the core to the microvillus membrane and may be an essential part of the supporting structure of the microvillus. Finally, recombinant CTGF showed no effect on Bax protein expression but significantly reduced Bcl2 protein expression. In this one-month survey study, we asked patients to complete a questionnaire about how they had experienced the FGE.

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A novel technique using a single-incision laparoscopic approach has been described for several laparoscopic procedures. Drug-induced liver injury (DILI) due to chemotherapeutic drugs is a significant cause of morbidity and mortality. The products of mild alkaline and mild acid hydrolysis of plasmalogens. The epidemiology of biopsy-positive giant cell arteritis: special reference to cyclic fluctuations. Recognition of oxidatively damaged and apoptotic cells by an oxidized low density lipoprotein receptor on mouse peritoneal macrophages: role of membrane phosphatidylserine. The ability to image in arbitrary double oblique planes provides comprehensive visualization of the heart. Neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) were immune response-related indicators. Research on the spontaneous flagyl dosing bacterial vaginosis fibrinolytic activity of the plasma in liver cirrhosis.

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