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Bionil (Glibenclamide)
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Bionil

Bionil is an inexpensive drug that helps to treat type 2 diabetes. It is slightly less popular than comparable drugs. Bionil is only available as a generic drug; all brands have been discontinued. Bionil is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.

Other names for this medication:
Benclamet, Betrol, Combidos, Daonil, Diabnil, Diolin, Dutrol, Eumet, Giclamide, Glibenclamide, Glibet, Glifil, Glime, Glinil, Glitrac, Glucored, Glucosafe, Glucosil, Glucotrac, Glutowin, Glybid, Glybonil, Glyboral, Glybovin, Glybovine, Glymep, Metclam, Sugatrol, Sugnl, Sycored

Similar Products:
Flomax, Mircette, Dulcolax, Hytrin, Ilosone, Zovirax, Cialis, Altace

Also known as: Glibenclamide

Description

{name} and metformin is a combination of two oral diabetes medicines that help control blood sugar levels.

{name} and metformin is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes. {name} and metformin is not for treating type 1 diabetes.

Dosage

Usual Adult Dose for Diabetes Type 2:

Doses provided as Bionil-metformin -As Initial Therapy in Patients with Inadequate Glycemic Control on Diet and Exercise Alone: Starting dose: 1.25 mg-250 mg orally once a day -Consider a starting dose of 1.25 mg-250 mg orally twice a day for patients with fasting blood glucose (FBG) greater than 200 mg/dL or HbA1c greater than 9% Maintenance Dose: Increase in increments of 1.25 mg-250 mg per day every 2 weeks up to the minimum effective dose to achieve glycemic control Maximum Initial Dose: 10 mg-2000 mg per day -Patients with Inadequate Glycemic Control on a Bionil (or another Sulfonylurea) and/or Metformin: Initial dose: 2.5 mg-500 mg or 5 mg-500 mg orally twice a day Maintenance Dose: Increase in increments of no more than 5 mg-500 mg to the minimum effective dose to achieve adequate blood glucose control Maximum Dose: 20 mg-2000 mg per day Comments: -Give with meals; 5 mg-500 mg dose should not be used as initial therapy due to an increased risk of hypoglycemia; initial doses should be conservative to avoid hypoglycemia largely due to Bionil and gastrointestinal side effects largely due to metformin. -For patients who are switching to combination therapy, initial doses should not exceed the daily dose of Bionil (or equivalent sulfonylurea) and metformin already being taken; the decision to switch to the nearest equivalent dose should be based on clinical judgement. -Addition of thiazolidinedione may be appropriate for patients not adequately controlled on Bionil-metformin; in patients experiencing hypoglycemia, consider reducing the dose of the Bionil component. -Monitor patients closely for signs and symptoms of hypoglycemia. Use: As an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus.

Detailed Bionil/metformin dosage information

Overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include hypoglycemia symptoms as well as the following:

  • seizures
  • loss of consciousness

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Side effects

The most common side effects associated with Bionil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Avoid drinking alcohol. It lowers blood sugar and may increase your risk of lactic acidosis.

If you also take colesevelam, avoid taking it within 4 hours after you take Bionil and metformin.

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In humans and mice, mutations in the X chromosome-linked gene L1 cause severe neurological defects in males. Functional remission of people with serious mental illness (SMI): psychometric properties of a new ROM-instrument. The effect of nicotine on the production of soluble fms-like tyrosine kinase-1 and soluble endoglin in human umbilical vein endothelial cells and trophoblasts. Analysis of dendritic spines revealed alterations in structural plasticity, whereas electrophysiological recordings demonstrated differential alterations in glutamatergic neurotransmission in the PrL and IfL cortex. High speed cinematography and frame by frame analysis were used to analyze knee kinematics of 6 dogs serially for 26 weeks following L4-S1 dorsal root ganglionectomy, which was performed to deafferentate one hindlimb. Reconstruction of large and complex periorbital defects from cutaneous cancer. Sequences were compared using special amino acid substitution matrices for the alternate frames of translation. The positive inductor is BMP4, and this induces the epidermal induction.

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