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Bionil (Glibenclamide)

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Bionil is an inexpensive drug that helps to treat type 2 diabetes. It is slightly less popular than comparable drugs. Bionil is only available as a generic drug; all brands have been discontinued. Bionil is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.

Other names for this medication:
Benclamet, Betrol, Combidos, Daonil, Diabnil, Diolin, Dutrol, Eumet, Giclamide, Glibenclamide, Glibet, Glifil, Glime, Glinil, Glitrac, Glucored, Glucosafe, Glucosil, Glucotrac, Glutowin, Glybid, Glybonil, Glyboral, Glybovin, Glybovine, Glymep, Metclam, Sugatrol, Sugnl, Sycored

Similar Products:
Flomax, Mircette, Dulcolax, Hytrin, Ilosone, Zovirax, Cialis, Altace

Also known as: Glibenclamide


{name} and metformin is a combination of two oral diabetes medicines that help control blood sugar levels.

{name} and metformin is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes. {name} and metformin is not for treating type 1 diabetes.


Usual Adult Dose for Diabetes Type 2:

Doses provided as Bionil-metformin -As Initial Therapy in Patients with Inadequate Glycemic Control on Diet and Exercise Alone: Starting dose: 1.25 mg-250 mg orally once a day -Consider a starting dose of 1.25 mg-250 mg orally twice a day for patients with fasting blood glucose (FBG) greater than 200 mg/dL or HbA1c greater than 9% Maintenance Dose: Increase in increments of 1.25 mg-250 mg per day every 2 weeks up to the minimum effective dose to achieve glycemic control Maximum Initial Dose: 10 mg-2000 mg per day -Patients with Inadequate Glycemic Control on a Bionil (or another Sulfonylurea) and/or Metformin: Initial dose: 2.5 mg-500 mg or 5 mg-500 mg orally twice a day Maintenance Dose: Increase in increments of no more than 5 mg-500 mg to the minimum effective dose to achieve adequate blood glucose control Maximum Dose: 20 mg-2000 mg per day Comments: -Give with meals; 5 mg-500 mg dose should not be used as initial therapy due to an increased risk of hypoglycemia; initial doses should be conservative to avoid hypoglycemia largely due to Bionil and gastrointestinal side effects largely due to metformin. -For patients who are switching to combination therapy, initial doses should not exceed the daily dose of Bionil (or equivalent sulfonylurea) and metformin already being taken; the decision to switch to the nearest equivalent dose should be based on clinical judgement. -Addition of thiazolidinedione may be appropriate for patients not adequately controlled on Bionil-metformin; in patients experiencing hypoglycemia, consider reducing the dose of the Bionil component. -Monitor patients closely for signs and symptoms of hypoglycemia. Use: As an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus.

Detailed Bionil/metformin dosage information


In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include hypoglycemia symptoms as well as the following:

  • seizures
  • loss of consciousness


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Side effects

The most common side effects associated with Bionil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Avoid drinking alcohol. It lowers blood sugar and may increase your risk of lactic acidosis.

If you also take colesevelam, avoid taking it within 4 hours after you take Bionil and metformin.

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In humans and mice, mutations in the X chromosome-linked gene L1 cause severe neurological defects in males. Functional remission of people with serious mental illness (SMI): psychometric properties of a new ROM-instrument. The effect of nicotine on the production of soluble fms-like tyrosine kinase-1 and soluble endoglin in human umbilical vein endothelial cells and trophoblasts. Analysis of dendritic spines revealed alterations in structural plasticity, whereas electrophysiological recordings demonstrated differential alterations in glutamatergic neurotransmission in the PrL and IfL cortex. High speed cinematography and frame by frame analysis were used to analyze knee kinematics of 6 dogs serially for 26 weeks following L4-S1 dorsal root ganglionectomy, which was performed to deafferentate one hindlimb. Reconstruction of large and complex periorbital defects from cutaneous cancer. Sequences were compared using special amino acid substitution matrices for the alternate frames of translation. The positive inductor is BMP4, and this induces the epidermal induction.

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Pre-Chernobyl samples had a mean (137)Cs activity concentration of 23 Bq kg(-1). Using generalised estimating equations (GEE) we examined the prevalence and correlates of use of the SEP amongst VIDUS participants followed from 1 December 2000 to 30 November 2003. The purpose of this study was to evaluate the antimicrobial activity of Calendula. Western analysis was used to assess changes in p53, p21WAF, p16INK4a, cyclin D1 and plasminogen activator inhibitor-1 (PAI-1) levels at senescence. Clinical characteristics and the incidence of BPD were compared between the two groups. It includes some history of PET, the basic formation of radionuclides in a cyclotron target, the processing of the precursor molecules into a useful PET radiotracer and the clinical significance and outlook for PET radiotracers. Our results suggest that differences in firmness of shiitake mushrooms during storage may be due to differences in cellulose and chitin concentrations. Vital reaction of the lungs caused by the aspiration of heated air. Fifty-six subjects were randomly assigned to two groups, trained and tested on a pitch memory task three times across 24 h.

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from the Atlantic threadfin Polydactylus octonemus (Girard) and reassignment of three species of Diplectanum Monticelli, 1903 from the Indo-Pacific Ocean. Acute susceptibility of aged mice to infection with Candida albicans. PDGF-A and PDGFR-alpha had moderate expression by immunohistochemistry and presented punctated deposits throughout cytoplasm of myoepithelial cells. People with dementia may benefit from palliative care which specifically addresses the needs of patients and families affected by this life-limiting disease. The nuclear pore complex protein Tpr is a common autoantigen in sera that demonstrate nuclear envelope staining by indirect immunofluorescence. Involvement of corticosterone in food intake, food passage time and in vivo uptake of nutrients in the chicken (Gallus domesticus).

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The I-neb Adaptive Aerosol Delivery (AAD norvasc medication and grapefruit ) System can be used with a new mode of breathing during inhalation of aerosol, the Target Inhalation Mode (TIM). The BS(Tin-1460) site is absolutely required for expression in cardioblasts, while BS(Tin-1425) is needed for high-level expression. Given the key role of angiogenesis in brain tumors, the expression of galectins in tumor-associated endothelial cells (EC) and the implication of galectins in angiogenesis, the present review will focus on the expression of galectins in ECs of normal brain and brain tumors. Despite these limitations, over the last five years an innovative community-based educational programme involving medical students, nurses and health educators is evolving at the relatively new medical school in this region. Complete bile drainage was performed in 16 male Wistar rats by surgical intervention. Villous adenomas are benign lesions, which are difficult to interpret because of their malignancy potential. This modulation of sensory processing first occurs within the extrastriate visual cortex and not within the striate or earlier subcortical processing stages. First, we compared rectal and tympanic temperatures in 37 consecutive patients. Transhiatal versus transthoracic esophagectomy: complication and survival rates.

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Is cytology reliable for epidermal growth factor receptor gene evaluation in non-small cell lung cancer?. This latter aspect has been demonstrated in vitro (potentiation of the phagocyte antimicrobial activity), ex vivo in immunocompromised animals and humans (restoration of various immune parameters) and in vivo (infection models using both sensitive and resistant species). Our data suggest that bioimpedance may be superior to echocardiography in determining volume load etodolac lodine 500 mg tablet in children with NS, because it is cost-effective, reliable, and relatively simple to perform. The observation that divergent therapies act through a common signal transduction pathway raises the possibility of developing new anti-cancer agents that lack the side-effects caused by events upstream of p38 MAPK. The results of the genome-wide association study showed that 2 loci (1q32.2 and 1p22.3) are likely to be susceptibility regions of mandibular prognathism: 1p32.2 is a novel locus, and identification of 1p22.3 supports the results of previous linkage analysis. Serum pro-oxidant-antioxidant balance and low-density lipoprotein oxidation in healthy subjects with different cholesterol levels.

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Comparison of proximal turndown of central slip combined with suture of lateral bands versus free tendon grafting for central slip reconstruction after an open finger injury. We report a novel three dimensional microfilter device that can enrich viable circulating tumor cells from blood. Comparative 16S ribosomal RNA sequence analysis was used for identification. A number of radiobiologic parameters of radiation-induced apoptosis were investigated in a syngeneic murine B-cell lymphoma, designated LY-TH. The buccal musculomucosal neurovascular island flap (posteriorly based), supplied by the buccal artery, its posterior buccal branch, and the long buccal nerve, can be passed through a tunnel under the pterygomandibular ligament for closure of mucosal defects in the palate, pharyngeal sites, the alveolus, and the floor of the mouth. Research conducted in recent years has elucidated the immune mechanisms underlying the rejection of xenografts and has led to the development of incisive therapeutic strategies, including the genetic engineering of donor animals.

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Protozoan Cysts Act as a Survival Niche and Protective Shelter for Foodborne Pathogenic Bacteria. The following contrast-enhanced sonographic criteria were quantified: time to peak, peak intensity, alpha (microvessel cross-sectional area), and beta (microbubble velocity). The patient was successfully treated by a partial resection of the thyroid gland using an ultrasonically activated scalpel and emergency tracheostomy. Glutathione S-transferase T1 null genotype and laryngeal cancer risk: a meta-analysis. T cell function in vitro is an independent progression marker for AIDS in human immunodeficiency virus-infected asymptomatic subjects. The serum leptin, adiponectin, tumor necrosis factor-alpha, interleukin (IL)-6, and C-reactive protein (CRP) levels were measured before and after non-surgical periodontal treatment. Increased Migratory and Activation Cell Markers of Peripheral Blood Lymphocytes in an Experimental Model of Nephrotic Syndrome. Adverse outcomes apparently associated with hypothermia led us to examine patients undergoing elective abdominal aortic aneurysm (AAA) repairs to test the hypothesis that hypothermia (temperature less than noroxin 400 mg plm 34.5 degrees C) is associated with increased morbidity and excess mortality rates.

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