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Bioprim (Trimethoprim)

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Bioprim (generic name: Co-trimoxazole; brand names include: Septra / Ciplin / Septrin) is a combination of two antibiotics (trimethoprim and sulfamethoxazole) used to treat a wide variety of bacterial infections.

Other names for this medication:
Actrim, Bacin, Bacta, Bactipront, Bactropin, Betam, Bismoral, Broncoflam, Cotrimol, Cotrimstada, Cotrix, Dientrin, Droxol, Gantrisin, Irgagen, Kanprim, Kepinol, Kombitrim, Lupectrin, Meprim, Methoxasol, Nufaprim, Oribact, Primadex, Ribatrim, Roxtrim, Septran, Servitrim, Sinatrim, Sitrim, Suftrex, Sulfa, Sulfametoxazol, Sultrian, Sumetrolim, Trimethazol, Trisul, Trisulfose, Wiatrim, Zoltrim

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Also known as: Trimethoprim


Sulfamethoxazole and trimethoprim combination is used to treat infections such as urinary tract infections, middle ear infections (otitis media), bronchitis, traveler's diarrhea, and shigellosis (bacillary dysentery). This medicine is also used to prevent or treat Pneumocystis jiroveci pneumonia or Pneumocystis carinii pneumonia (PCP), a very serious kind of pneumonia. This type of pneumonia occurs more commonly in patients whose immune systems are not working normally, such as cancer patients, transplant patients, and patients with acquired immune deficiency syndrome (AIDS).

Sulfamethoxazole and trimethoprim combination is an antibiotic. It works by eliminating the bacteria that cause many kinds of infections. This medicine will not work for colds, flu, or other virus infections.

This medicine is available only with your doctor's prescription.


Adults: The usual adult dosage in the treatment of urinary tract infections is 1 Bioprim DS (double strength) tablet or 2 Bioprim tablets every 12 hours for 10 to 14 days. An identical daily dosage is used for 5 days in the treatment of shigellosis.

Children: The recommended dose for children with urinary tract infections or acute otitis media is 40 mg/kg sulfamethoxazole and 8 mg/kg trimethoprim per 24 hours, given in two divided doses every 12 hours for 10 days. An identical daily dosage is used for 5 days in the treatment of shigellosis.


If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe nausea/vomiting/diarrhea, severe dizziness or drowsiness, mental/mood changes.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Side effects

The most common side effects associated with Bioprim are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Before using sulfamethoxazole with trimethoprim, tell your doctor or pharmacist if you are allergic to sulfa medications or trimethoprim; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, certain blood disorders (such as porphyria, anemia due to folate vitamin deficiency), history of blood disorders caused by trimethoprim or sulfa medications, vitamin deficiency (folate or folic acid), severe allergies, asthma, decreased bone marrow function (bone marrow suppression), a certain metabolic disorder (G6PD deficiency), underactive thyroid, mineral imbalances (such as high level of potassium or low level of sodium in the blood). Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths or sunlamps. Use a sunscreen and wear protective clothing when outdoors. If you have diabetes, this product may affect your blood sugar levels. Check your blood sugar levels regularly as directed by your doctor. Tell your doctor immediately if you have symptoms of low blood sugar (see Side Effects section). Your doctor may need to adjust your diabetes medication, exercise program, or diet. Older adults may be more sensitive to the side effects of this drug, especially skin reactions, blood disorders, easy bleeding/bruising, and a high potassium blood level. Patients with AIDS may be more sensitive to the side effects of this drug, especially skin reactions, fever, and blood disorders. This medication is not recommended for use during pregnancy especially near the expected delivery date because of possible harm to the unborn baby. Consult your doctor for more details. This drug passes into breast milk. While there have been no reports of harm to healthy infants, this drug may have undesirable effects on infants who are ill or premature or have certain disorders (jaundice, high blood levels of bilirubin, G6PD deficiency). Therefore, breast-feeding is not recommended for infants with these conditions. Consult your doctor before breast-feeding.

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Characterization of a K26Q site-directed mutant of human parathyroid hormone expressed in yeast. The bidirectional cross talk between nuclear and mitochondrial DNA is essential for cellular homeostasis and proper functioning. Up to a 2.35-fold increase in the final antibiotic yield and a 4-fold increase in the rate of bacitracin synthesis were observed in response to O(2)-enriched aeration. The aim of this study was to improve the MRI diagnosis of CMP, with special reference to the early stages and accurate staging. The simplifying assumptions that are used widely in theoretical population genetics may not always be appropriate for empirical population genetics. Four consecutive treatments with 1,2-dibromoethane (EDB) reduced the accumulation of PAH in male rats, but failed to alter TEA accumulation, BUN concentration or GPT and GOT activities in rats of either sex. In contrast to observations in previous reports, we believe these lesions are suitable for removal by endoscopic means, provided they are small in size and strictly submucosal in location. Therefore, self-efficacy seems an important target in the rehabilitation of patients living with SCI. In contrast to L-PLLs (1-5 kDa), H-PLLs (15-30 kDa) were more detrimental to both mitochondrial oxidative phosphorylation (OXPHOS) and glycolytic activity resulting in considerable intracellular ATP depletion, thereby initiating necrotic-type cell death. Submuscular placement or immediate replacement is indicated only in selected cases.

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BACTERIAL CONTAMINATION OF INDWELLING INTRAVENOUS POLYETHYLENE CATHETERS. Diagnosis of allergy to mold fungi in children with bronchial asthma. Moreover, long-lasting immunosuppression, as required after solid-organ transplantation, does not seem to be necessary. The review will demonstrate how early years interventions do or do not work in different contexts and with what outcomes and effects. Acute disorders of circadian and seasonal melatonin production in summer and autumn were discovered in patients with duodenal ulcer. The paper reports the radio-activity levels recorded at gonad and eye levels of the operator in positions most frequently held during the course of the most commonly performed scintigraphic examinations using a G.E.

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Remarkably, paraplegin-2 is targeted to the endoplasmic reticulum. Colorectal carcinoma (CRC) is third most common cancer worldwide with very heterogenous character. The effect of variation of cofactor and substrate structure on the action of phenylalanine hydroxylase. On the contrary, information regarding the MPC angiogenic process is still incomplete and requires further clarification. Taken together, these results suggest that MIF is involved in the up-regulation of UVA-induced MMP-1 in dermal fibroblasts through PKC-, PKA-, Src family tyrosine kinase-, MAPK-, c-Jun-, and AP-1-dependent pathways. We demonstrated that early ROS generation is critical for mitochondria damage and the activation of intrinsic apoptotic pathway. Histochemical demonstration of hyaluronic acid in human dermal mast cells. The renin-angiotensin-aldosterone system and hypertension in primary hyperparathyroidism. Association between interleukin-6 gene -174 G/C polymorphism and the risk of coronary heart disease: a meta-analysis of 20 studies including 9619 cases and 10,919 controls. The relation between upper thoracic and cervical spine degenerative disc disease is not well established.

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One of the most interesting characteristics of ornithine decarboxylase (ODC) is its extremely short half-life. The Trauma History Questionnaire and the PTSD module of the Structured Clinical Interview for DSM-III-R were administered to 180 male and female outpatients with a diagnosis of one or more DSM-III-R personality disorders. Apoptosis of Theileria-infected lymphocytes induced upon parasite death involves activation of caspases 9 and 3. Medical therapy can be effective in certain marginal cases of small vessel occlusion. Regular versus symptomatic aerosol bronchodilator treatment of asthma. The methodological quality of the included studies was assessed using criteria based on generally accepted principles of interventional research. Involvement of non-oxidative enzymes in mutagenic activation of urine from rats, given benzidine and some other aromatic amines. This study included all patients on whom a volume-viscosity clinical examination (MECV-V test) was performed to suspecting dysphagia. To date no nation-wide study has yet been undertaken in Spain to estimate the iodine deficiency.

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Therefore, the diverse mechanisms of action of carcinogenic agents in relation to their effects on specific stages in the natural history of cancer development allow for greater congruence of many of the theories of carcinogenesis. Results of clinical study of the antineoplastic antibiotic, bleomycin, in USSR. The study has a descriptive intervention-based design where group communication for partners of former, surviving intensive care unit (ICU) patients was evaluated. The initial clinical signs displayed by two horses with head trauma are described and related to the pathology and management of the condition, to illustrate the diversity of signs that may result from similar events. This paper describes a promising asymmetric cyclopropanation system for unfunctionalized olefins using readily available dipeptide N-Boc-l-Val-l-Pro-OMe as ligand. Percutaneous kidney biopsy provides the most expedient means of establishing the diagnosis. Patient care threatened by presence of concentrated lidocaine syringes. Interference with neuroinflammation by an anti-inflammatory reagent or overexpression of interleukin-10 in the brain was found to attenuate hypertension. Intra/extracardiac fenestrated modification leads to lower incidence of arrhythmias after the Fontan operation. Somatic and capsular factors of coliforms which affect resistance to bovine serum bactericidal activity.

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Incidental finding of undetectable anti-TNF drug levels in patients with stable long-term deep remission may identify a subset of patients whose clinical remission is no longer dependent on anti-TNF treatment. In Experiment 1, a spatial preference was extinguished by exposing mice to the water maze in the absence of a platform but in the presence of the distal spatial cues. A reporter construct containing the Aspergillus flavus beta-tubulin gene promoter fused to Escherichia coli beta-glucuronidase (GUS) has been shown to be a reliable tool for the indirect measurement of fungal growth in maize kernels. A simultaneous fit of all inactivation data was based on kinetic models that were derived from different inactivation mechanisms and comprised the material balances of several enzyme forms and the enthalpy balance characterizing the initial heating period of enzyme solution. Probability of altitude decompression sickness during a suited exit from a space ship having a near-Earth atmosphere. There are currently numerous data indicating that Nrf2 has an important amoxil antibiotic role in cancer radioresistance. The effects of systemic infusion of purified beta glucuronidase, lactic acid and a combination of these were studied in normal dogs from the viewpoints of hemodynamics and blood coagulation.

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HIPP MUA was essentially unaffected by photic pulse stimulation. This collagen-synthetic polymer composite was applied as a support for immobilization of enzymes for the purpose of providing a material surface with biological function. The main imaging features of this condition are briefly reviewed, together with its pathogenesis and the most common associations and differential diagnoses. It has recently been suggested that C-C chemokines may play a role in the organ-specific homing of lymphocytes, but there is not enough in vivo evidence in intestinal mucosa. Axial computed tomography with coronal and sagittal reconstruction provides useful information to surgeons regarding the relationship between the is rulide penicillin based mandibular third molar and the mandibular canal.

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Overall patient satisfaction is benefited, despite a higher rate of permanent hypothyroidism. The authors have previously found a strong familial aggregation of pyloric stenosis indicating a genetic influence. Modelled HQ higher than unity and STEL exceedance probabilities higher than 0.5 were found for FA, whereas estimated TOL health risks were notably lower according to high exposure limits. Current immunoassays are lacking analytical specificity due to high cross-reactivities between circulating forms. Moreover, it enables identification of novel kinase targets for selected therapeutic indications as demonstrated in the KinScreen application. In 30 patients (group 1) during surgery conventional neuroleptanalgesia was accompanied by intravenous low-intensity laser blood irradiation (ILILBI). Caspase-dependent apoptosis in fulminant hepatic failure induced by herpes simplex virus in mice. Two clones selected from the murine sarcoma line B77 showed a different capacity to produce the tumor-derived chemotactic factor known as JE. Long-term results of first-line sequential high-dose etoposide, ifosfamide, and cisplatin chemotherapy plus autologous stem cell support for patients with advanced metastatic micardis hct dose germ cell cancer: an extended phase I/II study of the German Testicular Cancer Study Group.

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coli of Chlamydia trachomatis antigen recognized during human infection. Combining multiset resolution and segmentation for hyperspectral image analysis of biological tissues. Similar solutions containing heat-denatured (DE) glucose oxidase served as a control treatment. The development of stereoscopic mechanisms in the visual cortex of the cat. These findings suggest that SU6668 has a promising therapeutic effect on the progression of MPM in vivo through its anti-angiogenic effects. From June 2008 to March 2010, we enrolled 31 heart transplantation (HT) patients in this study.

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Less well known is the fact that long-term, progressive HIV disease is associated with the development of cognitive deficits. The antigen-induced release of histamine both in vitro from rat peritoneal cell suspensions containing mast cells actively sensitized with IgE antibody and in vivo from passively sensitized skin can be inhibited by relatively high doses of nicotinamide. DNA diagnosis may play a significant role in the identification of cherubism. No changes occurred in the control arm or in the immersed arm of normal subjects. The luvox dosing range chemokine system consists of four different subclasses with over 50 chemokines and 19 receptors. Based on surrogate data obtained by this procedure we investigate the robustness of the recently proposed method empirical de-Poissonization (Ehm et al., 2007). Tackling the sexual and reproductive health and rights of adolescents living with HIV/AIDS: a priority need in Nigeria. The results suggest that exposure to media campaign messages in Florida has led to increases in quit attempts.

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Atranorin, the compound with the depside structure, is one of the most common lichen secondary metabolites, characteristic for numerous lichen families but rarely found in some mosses and higher plants. We reviewed the literature regarding atypical mycobacterial infections and prophylaxis used in other immunocompromised patients, as well as the current data regarding cDGS detection through TREC newborn screening. The gas-phase excitation spectrum of 1H-phenalene and its radical cation are recorded using laser spectroscopy coupled to mass-spectrometry. Proceedings of the Histochemical Society XVI Symposium held in Leiden/Noordwijk. Oxygen regulates amino acid turnover and carbohydrate uptake during the preimplantation period of mouse embryo development. Ribonucleotide reductase is the only enzyme known to catalyze the direct conversion of a ribonucleotide to a deoxyribonucleotide. EPs view PC skills as important for EM practice and report that they are not yet adequately educated and trained in providing PC.

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