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Capiibine (Capecitabine)
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Capiibine

Capiibine is used together with docetaxel to treat metastatic breast cancer (breast cancer that has spread to other parts of the body) in patients who have received other medicines (eg, paclitaxel) but did not worked well, or in patients who cannot receive cancer medicines anymore.

Other names for this medication:
Capecitabine, Capegard, Capehope, Capget, Capiibine, Capres, Capscare, Captabin, Capxcel, Distamine, Naprocap, Xabine, Xelocel

Similar Products:
Chloromycetin, Levaquin, Lopid, Provera, Flagyl, Furadantin, Ultram, Ventolin, Addyi, Maxalt

Also known as: Capecitabine

Description

{name} (capecitabine) is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body.

{name} is used alone or in combination chemotherapy to treat colon cancer, breast cancer, or colorectal cancer.

{name} is sometimes used when cancer has spread to other parts of the body (metastatic).

Dosage

Usual Adult Dose of Capiibine for Colorectal Cancer:

MONOTHERAPY: For first line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles ADJUVANT TREATMENT IN PATIENTS WITH DUKES' C COLON CANCER: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles for a total of 8 cycles (24 weeks) Comments: -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Colorectal Cancer: -As monotherapy for adjuvant treatment in patients with Dukes' C colon cancer who have undergone complete resection of the primary tumor when treatment with fluoropyrimidine therapy alone is preferred; this drug was non-inferior to 5-fluorouracil and leucovorin (5-FU/LV) for disease-free survival (DFS); physicians should consider results of combination chemotherapy trials, which have shown improvement in DFS and OS, when prescribing this drug as a single-agent in the adjuvant treatment of Dukes' C colon cancer -As first-line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred; combination chemotherapy has shown a survival benefit compared to 5-FU/LV alone; survival benefit over 5-FU/LV has not been demonstrated with this drug as monotherapy; use of this drug instead of 5-FU/LV in combinations has not been adequately studied to assure safety or preservation of the survival advantage

Usual Adult Dose of Capiibine for Breast Cancer:

MONOTHERAPY: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period combined with docetaxel 75 mg/m2 as a 1 hour IV infusion, every 3 weeks IN COMBINATION WITH DOCETAXEL: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles Comments: -The manufacturer prescribing information for docetaxel should be consulted for premedication advice. -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Breast Cancer: -In combination with docetaxel for the treatment of patients with metastatic breast cancer after failure of prior anthracycline-containing chemotherapy -As monotherapy for the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen or resistant to paclitaxel and for whom further anthracycline therapy is not indicated (e.g., patients who have received cumulative doses of 400 mg/m2 of doxorubicin or doxorubicin equivalents); resistance is defined as progressive disease while on treatment, with or without an initial response, or relapse within 6 months of completing treatment with an anthracycline-containing adjuvant regimen

Detailed Capiibine dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Capiibine are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

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On control of singleton attractors in multiple Boolean networks: integer programming-based method. Elevated lung clearance index in infants with cystic fibrosis shortly after birth. However, the neutralizing antibody responses were specific for DEN1 and DEN2 serotypes. New technic of bronchial lipiodolography: lipiodol-sulfonamide bronchography. Deletional mutation analysis confirmed that this locus is essential for F. The aim of this study was to analyze the physicochemical properties, pharmacodynamic effect, and pharmaceutical and clinical equivalence of the reference drug propofol as well as a similar formulation. Our previous analysis revealed that Scythe can bind to a proteasomal subunit via N-terminal domains and that the domains are required for appropriate development of Xenopus embryos. ASPN might co-function with COL12A1, and they both might be the targets of miR-21. A common locus for the observed skeletal anomalies, including the HOXD genes and surrounding regulatory sequences, was delineated.

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An eight-month-old girl with hypoplastic left heart syndrome, who underwent a modified Norwood operation at the age of two days, and a Hemifontan operation at five months of age, had severely impaired ventricular function and new electrocardiographic changes. A comparison of the levels of hydroxamic acids in Aegilops speltoides and a hexaploid wheat and effects on Rhopalosiphum padi behaviour and fecundity. Furthermore, using this process we demonstrated a clear metal-insulator transition in an ultrathin Bi2Se3 film by gate-tuning its Fermi level into the hybridization gap formed at the Dirac point. A comprehensive understanding of the role of IONM for prevention of nerve injuries is critical to maximize safety during surgery of the anterior compartment of the neck. This method offers a new vision on skin aging, in its variable response to a standard deformation that appears mostly driven by chronological aging. Primary malignant melanoma of the esophagus: a clinicopathologic study of a case with comprehensive literature review. The instructors trained all clinic midwives working in their first-level facilities as part of a before-and-after study of the effect of ENC training on early neonatal mortality conducted from Oct 2004 to Nov 2006. The inclusivity and exclusivity tests demonstrated high sensitivity and specificity of the multiplex real-time PCR assay. Effectively reducing amylase testing using computer order entry in the emergency department: quality improvement without eliminating physician choice.

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After the 18 months treatment, the size of the lesion reduced to 1 cm, then the remaining lesion was excised. Inconsistency in the provider as well as the content of the dietary interventions leaves the difficulty of summarizing the components of effective dietary interventions. Persistent CNS toxicity in a patient receiving posaconazole tablets after discontinuation of voriconazole due to supratherapeutic serum levels. Understanding the factors that influence the provision of end-of-life care in acute and long-stay facilities in Ireland can help health professionals give more focused support and ensure that influencing factors are addressed so that older people at end-of-life receive quality end-of-life care. This novel model indicates that diet-induced NASH fibrosis is exacerbated by diabetes and attenuated by insulin therapy. Pathological studies support the risk of inflammation in high-risk patients to a greater extent than the degree of vessel stenosis. The importance of progesterone metabolism in the initiation of the birth processes. Glacial refugia in pathogens: European genetic structure of anther smut pathogens on Silene latifolia and Silene dioica. We report that increasing Pax6 level is sufficient to push neural progenitors toward cell cycle exit and neuronal commitment via Neurogenin 2 (Ngn2) upregulation. A systematic review was attempted, to assess whether ALT size affects the incidence of vascular compromise after primary thinning.

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Outcomes of a pivot table, Likelihood Ratio (LR) calculations and Multivariate Analysis (MVA) were compared. To the best of our knowledge, this is the first time that SOLiD sequencing has been used in a human sample. TRPM8 is a member of the transient receptor potential ion channel superfamily, which is expressed in sensory neurons and is activated by cold and cooling compounds, such as menthol. A standardized obstacle course for assessment of visual function in ultra low vision and artificial vision. Transplantation of embryonic stem cells improves nerve repair and functional recovery after severe sciatic nerve axotomy in rats. In the context of a large, random assignment, controlled study evaluating the relative effectiveness and safety of antipsychotic medication (CATIE), we examined the relationship between treatment outcome and 2 family variables: their presence and their ability to support treatment adherence. Nearly half of GBC patients also have jaundice, which is a mark of the advanced stage of GBC. External biasing forces are often applied to enhance sampling in regions of phase space which would otherwise be rarely observed. Treatment fidelity was carried out using measures of delivered versus planned treatment content and quality of therapy. This article tries to show some aspects on how this increase in efficiency might be achieved.

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Cytotoxic and HIV-1 enzyme inhibitory activities of Red Sea marine organisms. Intervention effects on suicide detection and referral to mental health specialty care were evaluated with mixed-effects multilevel models in intent-to-treat analyses. Fluorescence, chemical crosslinking, and Saturation Transfer Difference NMR data suggested that PEP87 binds to the neutral pH conformation of HA and disrupts the HA structure, without affecting its oligomerization state. In these applications, predictive performance of the test is of interest. Consequently, SCCH leads to significantly impaired quality of life.

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The role of nucleus accumbens shell GABA receptors on ventral tegmental area intracranial self-stimulation and a potential role for the 5-HT(2C) receptor. Acute myeloblastic leukaemia (AML) patients are at high risk of suffering from invasive fungal infections (IFI). From 1999 to 2010 the GISTs detected at surgical exploration or preoperative assessment for other malignancies plus primary-GISTs, were recorded and reviewed. Intracellular hepatitis B virus increases hepatic cholesterol deposition in alcoholic fatty liver via hepatitis B core protein. A recent interpretation of the pathogenetic role of asbestos fiber size in the development of mesothelioma and in the possibility of mesothelioma prevention needs clarification. The findings may help to interpret high resolution CT in the context of smoking and gender and highlight the heterogeneity of structural changes in COPD. Implementation of a mandatory rheumatology osteoporosis consultation in patients with low-impact hip fracture. Previous studies suggest that the production of VEGF, platelet derived growth factor (PDGF) and other important cytokines is not only triggered by hypoxia but also by mTOR itself.

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Prompt treatment and periodic follow-ups are necessary after traumatic CCD, based on accurate dimensions and configuration by UBM. In this paper, we describe for the first time the expression and localisation of both collectins in various porcine tissues using a combination of in situ hybridisation (ISH), RT-PCR and immunohistochemistry (IHC). By understanding those factors that contribute to handover quality, it is possible to develop targeted interventions aimed at improving the quality of Emergency Department nurse-to-nurse shift handover. Incidence of surgical site infections in sub-Saharan Africa: systematic review and meta-analysis. The ES cells robustly maintained pluripotency in Wnt3a-CM on feeder free condition. With thorough anatomical knowledge of this region, it offers equivalent brow elevation, shorter operative times, smaller incisions, similarly low complications rates, and patient satisfaction and eliminates the need for costly and cumbersome endoscopic equipment.

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In addition to high affinity primary motif interactions, we also observe interactions with secondary motifs. A wealth of functional information generated from wet lab experiments now exists but cannot be easily interrogated by the user. Clinical outcome in cardiorenal syndrome (CRS) Type 2 and treatment with dialysis. The N terminal region of the PA subunit has been shown to play a key role in various functions through a number of conserved amino acid residues. Diagnosis was made by transrectal exam and later confirmed by post-mortem examination. Therapeutic principles in treatment of severe acute pancreatitis.

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Histochemical and ultrastructural features of the lingual epithelium of the rat snake (Elaphe climacophora). The analysis included 332 adult patients who had fecal incontinence for more than a year with at least monthly leakage of solid, liquid, or mucous stool. Molecular phylogeny of the Drosophila auraria species complex and allied species of Japan based on nuclear and mitochondrial DNA sequences. Meta-analyses were not possible due to between-study differences in the way delays were reported. This review focuses on recent advances of BAT function in the metabolic aspect and the relationship between BAT and cancer cachexia, a pathological process accompanied with decreased body weight and increased energy expenditure in cancer patients. The present findings have implications for response strategy efficacy and measure evaluation, revision, and construction. The location of the spinodal line as found in our simulations is consistent with analytical predictions.

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Mice were treated with a macrophage depletion agent (liposome-encapsulated clodronate) or with a neutrophil depletion agent (cyclophosphamide or the rat anti-mouse granulocyte bisoprolol cost monoclonal antibody RB6-8C5), and the animals were then infected intraperitoneally or by aerosol challenge with fully virulent, ungerminated B. Eighty IPD and 30 VP patients, and 60 controls were recruited into this study. Isolated intraluminal colonic recurrence in the absence of local invasion is extremely rare. The protease inhibitor Elafin prevents intestinal inflammation in mouse models of colitis and might be developed as a therapeutic agent for inflammatory bowel disease. DFT calculations have been carried out to study the detailed mechanism of Pd-catalyzed intermolecular coupling reactions of 2-silylaryl bromides with alkynes via selective cleavage of C(sp(3))-Si bonds. Lumbar Extension during Stoop Lifting is Delayed by the Load and Hamstring Tightness.

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Stress distribution in a maxillary central incisor restored with titanium post is greater than when restored with glass fiber post. This protocol describes the use of glufosinate ammonium to select transformed Arabidopsis plants. Keratin 10 (epidermal differentiation marker) was expressed in the suprabasal layer of bilayered tissue-engineered skin in the mixed fibroblasts and ADSCs group. The efficacy of the various methods was evaluated by measuring the quantity and quality of DNA by UV spectrophotometry and albenza generic by quantitative PCR (qPCR) using Cyanobacteria-specific primers. NAC transcription factors form a large plant-specific gene family involved in the regulation of tissue development and responses to biotic and abiotic stresses. This is particularly the case when one considers that any cell may have copies of similar binding domains found in numerous proteins. When we validated our model using the largest registry of familial pancreatic cancer, our model provided accurate risk assessment. A comparative analysis of auditory perception in humans and songbirds: a modular approach. Hence, improvement in the health services that leads to a shorter waiting time may increase the satisfaction level of patients.

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Nested effect models (NEMs) have been introduced as a statistical approach to estimate the upstream signal flow from downstream nested subset structure of perturbation effects. In patients with alcoholic liver diseases (ALD), liver iron is increased and the resulted lipid metabolite 4-hydroxynonenal-protein adduct was also increased. IDH1/2 gene hotspot mutations in central nervous system tumours: analysis of 922 Chinese patients. The association of serum prolactin concentration with inflammatory biomarkers - cross-sectional findings from the population-based Study of Health in Pomerania. The main outcome measure was survival three months after discharge from our department. Our review of the literature reveals the etiology of PVPS is still uncertain, as multiple theories still prevail. Slumbering mucosal immune response in the cervix of human papillomavirus DNA-positive and -negative women.

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Studies of adenosine triphosphate (ATP)-induced calcium signaling in HeLa cells were demonstrated using this developed method. We sought to investigate the effect of the germline KIT K509I mutation on human mast cell development and function. Orf virus ORFV121 encodes a novel inhibitor of NF-kappaB that contributes to virus virulence. Levels of several biomarkers change with older age in healthy individuals. This increased risk of mortality may have been due to the association between psychiatric disorders and adherence to antidiabetes medications observed in the present study. Patients with AF have good immediate results, but poorer long-term outcome after PBMC. Influenza A was detected in a small percentage of poultry traded in LBMs in Kenya. For example, the fastest change (in both patients and admissions) took place in the period 1953-54 to 1973-74, followed by the period 1974-75 to 1984-85.

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The development of nanotechnology-based drug delivery systems for AmB is a promising avenue since nanoparticles have the ability to target drugs to the infected cells, and their prolonged drug release profile permits longer contact between the drug and the fungi/parasite. This is a retrospective study of 38 patients with parotid tumors operated and hospitalized in the department of stomatology and maxillofacial surgery university hospital of Treichville (Abidjan), during the period from January 2005 to December 2009 included, so a period of 5 years. Poor baseline visual acuity (24-34 ETDRS letters) is a predictor of maximum gain in visual acuity. The differential diagnosis and malignancy criteria of GI PEComas will be discussed. There were no significant differences in age, clinical stage and histological grade among each group. Continuous venous to venous hemodialysis (CVVHD) is helpful in managing a condition with unstable hemodynamics.

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Long-term recovery of irradiated prostate cancer increases cancer stem cells. The pathogenetic role of cytotoxic cells is increasingly evident, as well as the deficit of cells and the factors regulating the autoimmune response. Light drinkers become moderate drinkers under social influence, moderate drinkers may change environments and become heavy drinkers. Stereoselective metabolism of drugs is most commonly the major contributing factor to stereoselectivity in pharmacokinetics. Regulation of Abro1/KIAA0157 during myocardial infarction and cell death reveals a novel cardioprotective mechanism for Lys63-specific deubiquitination. We investigated the way dialysate calcium (dCa) level can influence arterial stiffness (AS), measured by stiffness index (SI), a surrogate of pulse wave velocity, and reflection index (RI), a measure of the amount of pulse wave reflection, derived by digital volume pulse (DVP). The Expression implication of GDNF in ventral horn and associated remote cortex in rhesus monkeys with hemisected spinal cord injury. In this study, we sought to measure treatment culture (beliefs, values, and normative practices associated with medication prescribing and administration) in two samples of nursing homes (in Northern Ireland and New Zealand) and to document the range of scoring achieved by staff in both countries. FRC posts and CPBC could be promising materials to strengthen non-vital structurally compromised teeth. Preoperative erythropoietin administration in patients with prostate cancer undergoing radical prostatectomy without transfusion.

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Vitamin D levels in children affected by vernal keratoconjunctivitis. Filtering facepiece respirators are in high demand during infectious disease outbreaks, potentially leading to supply shortages. In the past two decades, organic chemists have begun to harness the synthetic potential of these biocatalysts to develop efficient chemoenzymatic synthesis of complex natural products. Apicomplexan parasites undergo metabolic shifts in adaptation to environmental changes. Analysis of the digested antibodies by LC-MS provided a quick estimate of the level of afucosylation. Although the exact electro-chemical mechanism for the efflux remains to be figured out in the future research, the good agreement of the present model with observations suggests that the efflux must get stronger as the lactate concentration in RBCs increases. The role of vacuum assisted closure and other management options are discussed which resulted in full recovery of the patient after three years finally. Sexuality on the whole and erectile response particularly are not alien to psychosocial and couple features.

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Successful gamma training was accompanied by increased gamma power at other what drug classification is lanoxin cortical locations and progressively enhanced cross-frequency coupling between gamma and slow oscillations (3-12 Hz). HOT regions function as patterned developmental enhancers and have a distinct cis-regulatory signature. Consultation management system software was developed and integrated into the hospital information system. There is an emerging trend in immunotoxicological studies to use the multiplex technologies for testing the safety and the efficacy of new pharmaceuticals by using cytokines profiling as biomarker. Occurrence of IgE in foals: evidence for transfer of maternal IgE by the colostrum and late onset of endogenous IgE production in the horse. Disablement theory has been characterized as the sequence of events that occurs after an injury, but little research has been conducted to establish how disablement is experienced and described by physically active persons. Two reviewers independently assessed 35 studies that met the inclusion criteria. Condensin II knockdown rescued the abnormal chromosome condensation phenotype in SET-depleted cells. Surgical gastrostomy, while considered a smaller procedure, is not without complications and mortality.

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This review summarizes the existing literature of race-specific associations between risk factors and prostate cancer in order to examine whether associations differ. Effects of industrial waste water on heavy metal accumulation, growth and biochemical responses of lettuce (Lactuca sativa L.). The efficacy of the treatment in these children was summarized and evaluated. Commonly, results were significant as group statistics only because source localization accuracy was limited by factors such as residual noise and head motion. LC-MS based serum metabonomic analysis for renal cell carcinoma diagnosis, staging, and biomarker discovery. Rising incidence of Pneumocystis jirovecii pneumonia suggests iatrogenic exposure of immune-compromised patients may be becoming a significant problem. Many guidelines do not include any GI tools, or a variety of GI tools for different stakeholders that may be more likely to prompt guideline uptake (point-of-care forms or checklists for clinicians, decision-making or self-management tools for patients, implementation and evaluation tools for managers and policy-makers).

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Therefore we sought to investigate the role of NER factors Xeroderma Pigmentosum A (XPA), XPB and XPD in oxidative DNA damage-repair by subjecting lymphoblastoid cells from patients suffering from XP-A, XP-D and XP-B with Cockayne Syndrome to hydrogen peroxide (H2O2). BALB/c mice were immunized intraperitoneally with ovalbumin (OVA) with and without cimetidine. Logistic regression analysis was used to control for independent risk factors associated with nephropathy. Replacement should be used sparingly until further conclusive data regarding the efficacy and safety of testosterone become available. On the basis of our recent findings of oncogenic KRAS-induced interleukin-8 (IL-8) overexpression in non-small cell lung cancer, we assessed the clinicopathological and prognostic significances of IL-8 expression and its relationship to KRAS mutations in lung adenocarcinomas. The method presented here can be widely applied in individual-based simulation models and will turn model selection and evaluation in this type of models into a more transparent, effective, and efficient exercise. In the present study, we attempted to explore the reason for failed IRA identification by ECG based on the comparison between ECG records and coronary angiographic findings. These phenomena were reversed in cells transfected with Smad7 siRNA. A summary of ongoing efforts to characterize the proteome of these unique prostate cancer-associated exosomes and their potential applications for use in biomarker assays is presented. Thus, SgII is present in LDCV and non-LDCV compartments of various neural cells.

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