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Cardiorex (Diltiazem)

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Cardiorex is a benzothiazepine derivative with antihypertensive and vasodilating properties. Approved in 1982 by the FDA, it is a member of the non-dihydropyridine calcium channel blockers drug class. It works through various mechanisms of action, but it primarily works by inhibiting the calcium influx into cardiac and vascular smooth muscle during depolarization.

Other names for this medication:
Altiazem, Angizem, Cardem, Cardiorex, Cartia, Coriem, Dicard, Dilacor, Dilcardia, Dilcontin, Dilcor, Dilgard, Dilocor, Dilter, Diltia, Diltiaz, Diltiazem, Dilticard, Diltime, Diltp, Dilzem, Heartil, Icidil, Ionozem, Kaizem, Masdil, Onzem, Taztia, Tiamate, Tiazac

Similar Products:
Provigil, Temovate, Zetia, Atarax, Estrace

Also known as: Diltiazem


{name} (diltiazem) is a calcium channel blocker. It works by relaxing the muscles of your heart and blood vessels.

{name} is used to treat hypertension (high blood pressure). It may be used alone or in combination with other high blood pressure medications.

{name} is also used to treat chronic stable angina (chest pain) and angina due to coronary artery spasm.


This section provides information on the proper use of a number of products that contain diltiazem. It may not be specific to Cardiorex CD. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended-release tablet, extended-release capsule, or tablet whole. Do not open, crush, or chew it. It is best to take the extended-release capsule on an empty stomach.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For chest pain: For oral dosage form (extended-release capsules): Adults—At first, 120 milligrams (mg) once a day in the morning. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 180 milligrams (mg) once a day, either in the morning or evening. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults—At first, 30 milligrams (mg) four times a day before meals and at bedtime. Your doctor may increase your dose if needed. Children—Use and dose must be determined by your doctor.

For high blood pressure: For oral dosage form (extended-release capsules): Adults—At first, 180 to 240 milligrams (mg) once a day in the morning. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 180 to 240 milligrams (mg) once a day, either in the morning or at bedtime. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of diltiazem can be fatal.

Overdose symptoms may include slow heartbeat, weakness, chest pain, shortness of breath, or fainting.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Cardiorex LA dosage information

Side effects

The most common side effects associated with Cardiorex are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Grapefruit and grapefruit juice may interact with diltiazem and lead to unwanted side effects. Discuss the use of grapefruit products with your doctor.

Cardiorex may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Avoid drinking alcohol while taking diltiazem.

Avoid taking herbal supplements containing St. John's wort at the same time you are taking diltiazem.

what happens if you overdose on diltiazem

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Although hyoscine butyl bromide (HB) and glucagon (GL) are often used as antispasmodic drugs during esophagogastroduodenoscopy (EGD), these agents may cause adverse effects. Recent studies have confirmed inflammatory factors and metabolic syndrome (MetS) as important cardiovascular disease (CVD) risk factors. The results indicate that changes in the release of active and inactive renin do not always run in parallel. pallidum SOD assayed by spectrophotometric analysis or activity staining following polyacrylamide gel electrophoresis. Subsequently the hemolysis receded and the patient regained graft function. The present study compares the anorectic activity of d-fenfluramine and its metabolite d-norfenfluramine in three animal species. Superoxide radicals in high concentrations were generated from alkaline H2O2 without using catalysts or irradiation.

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Projections suggest that, at a global scale, the northern clade could contract its solitarious recession range, while the southern clade is likely to expand its recession range. Understanding the roles of these receptors will help us to better understand how the kidney functions both in health and in disease. It further supports its therapeutic potential for the treatment of urinary calculi. Four motivation categories were identified: risk, pleasure, efficiency and ability to control the dimension. However, the CPR quality en route and while in transfer to the emergency department (ED) for out-of-hospital cardiac arrests (OHCAs) remains uncertain. The possible role of purinergic nerves in insulin secretion is discussed. THE EFFECT OF STARVATION, INFECTION, AND INJURY ON THE METABOLIC PROCESSES AND BODY COMPOSITION. Results revealed that relatively higher levels of both anticipatory and consummatory anhedonia were linked with fewer past-related words and by lesser use of first-person plural pronouns. Alteration of heme metabolism in a cellular model of Diamond-Blackfan anemia. A charge equilibration formalism for treating charge transfer effects in MD simulations: Application to water clusters.

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A high rate of false arrhythmia alarms in the intensive care unit (ICU) leads to alarm fatigue, the condition of desensitization and potentially inappropriate silencing of alarms due to frequent invalid and nonactionable alarms, often referred to as false alarms. A quantitative examination of the sources of speech discrimination test score variability. Pelvic floor muscle strength was measured with a vaginal balloon connected to a fiber optic micro tip transducer (Camtech AS, Sandvika, Norway). Synthesis of N-substituted acridinediones and polyhydroquinoline derivatives in refluxing water. Animal models have shed light as to the potential contribution of dysregulated innate immunity in chronic sinonasal inflammation. Furthermore, we demonstrate the use of a more denaturing urea/thiourea lysis buffer for solubilization, by comparing its effectiveness for solubilization of small heat-shock proteins from smooth muscle with the often utilized RIPA lysis buffer. Mismatch repair gene expression defects contribute to microsatellite instability in ovarian carcinoma. Specific transcellular carbocyanine-labelling of rat retinal microglia during injury-induced neuronal degeneration. Synthesis and binding properties of new selective ligands for the nucleobase opposite the AP site. Modeling and laboratory studies demonstrate the importance of evaluating P removal technologies under controlled conditions before field deployment, and field studies highlight bactrim dosage children several challenges to P removal that may be unanticipated in the laboratory, including limited P retention by filters during storms, as well as clogging of filters due to sedimentation.

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The effects of extracts and phytochemical components of Sutherlandia frutescens, on the in vitro absorption and metabolism of the protease inhibitor, atazanavir were thus investigated. Crystallin growth is under a combination of genes and their products in time and space to complete the coordination role of the guidance. Ham-positive red cells induced in vitro by N-acetylcysteine or D-penicillamine. Cases with diabetic nephropathy had a significantly higher frequency of the MTHFR 677 TT, 677 CT, ACE DD mutant genotypes compared with diabetic cases without nephropathy. Examination of autophagy markers LC3-I and LC3-II demonstrated that both Gn expression and Sin Nombre hantavirus (SNV) infection induce autophagy in cells. DC is safe in clinical practice and reduces mortality after MIMCA, especially if it is performed within 48 hours from stroke onset. Health adjusted life years (HALYs) gained and healthcare cost savings from diseases averted were estimated. Despite the complex methodology of these meta-analyses, the randomized trials used for analysis are fraught with inconsistencies, including the availability of cancer outcomes, a brief time to follow-up as compared with the latency of cancer, and heterogeneous use of antihypertensive agents.

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Appropriate initial dose was 10-15 mg/day and maintenance one was 75 mg/day in high PRA group. Solvation of fluoro-acetonitrile in water by 2D-IR spectroscopy: A combined experimental-computational study. Serum creatine phosphokinase changes following needle electromyographic tudies. A cohort of 237 serum samples from 160 patients with early colorectal neoplasms (148 precancerous lesions and 12 cancers) and 77 healthy subjects was analyzed in a three-step approach that included a comprehensive literature review for published biomarkers, a screening phase, and a validation phase. The value of serum carbohydrate deficient transferrin assays in the differential diagnosis of abnormal liver toxicity tests is emphasized.

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Simultaneously, a contribution to the prognosis of rectal carcinoma. In DFMO treated animals there was an inhibition of ODC activity in cochlear tissues as well as in intestinal mucosa. Studies of two kindreds with the MEA-I syndrome prompted us to challenge the long-standing concept that endocrine involvement in this syndrome may be limited to one or two endocrine glands. Immunoperoxidase localization of prostatic acid phosphatase in prostatic carcinoma with sarcomatoid changes. Attempt at objective evaluation of the effect of balneotherapy in progressive polyarthritis. Since the amount of physician visits, work absenteeism and a higher amount of procedures were related to a diminished HRQoL, the patients who are most often met by professional caregivers are often those whose HRQoL needs to be more adequately addressed. A species dependent interaction between venom enzyme, fibrinogen and serum proteinase inhibitors creates specific differences in dose response relationship.

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Cryostat sections were taken from kidneys of affected mice, stained with fluorescein-conjugated anti-mouse immunoglobulin, and the extent of immune complex glomerulonephritis was determined. We eliminated some potential factors previously suggested in the literature, including insolation, the position of our planet with respect to the sun, food availability, and maternal workload. This has important implications for understanding the neural systems underlying singulair 10 mg tablet image the feeding phenotype of PWS and the contribution of imprinted genes to abnormal feeding behaviour more generally. In order to provide an overview of the efficacy and safety of the lidocaine plaster in the treatment of different neuropathic pain conditions, all efficacy and safety studies (randomized, controlled, or open-label with well described methodology), case reports, and pharmacological studies on the lidocaine plaster retrieved from a PubMed literature research (1960-March 2012) plus additional references identified from retrieved articles were included. These lesions developed in the same way as macular lesions, but they were complicated by a schisis in the left eye. Functional characterization of olfactory binding proteins for appeasing compounds and molecular cloning in the vomeronasal organ of pre-pubertal pigs. the results from the present study indicated that BSA-complexed LNA might modestly interact with ZnO NPs, but did not significantly affect ZnO NPs and BSA-induced biological effects in HepG2 cells. Prevalence of thrombophilia was high in children with retinal hemorrhage and in 1 case the question of hemorrhage adjudicated as abuse was considered in light of a history of a fall.

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Effects of changes in maternal--fetal pH on the transplacental equilibrium of bupivacaine. The systemic administration of gemcitabine rocaltrol drug class (Gemzar) is currently considered the standard first-line treatment for patients with advanced disease. Moreover, siblings show additional activation in the medial frontal cortex that may be protective. Differential effects of antibodies to rat liver tritosome proteins on the activity of some lysosomal hydrolases in vitro. Here, we measured EPR spectra of the 14N- and 15N-labeled perdeuterated TEMPONE radicals in normal and supercooled water at various concentrations. Studies of stimulant medications generally reported positive effects on cognitive performance. Dissociating medial temporal and basal ganglia memory systems with a latent learning task. It had not previously been determined whether the high rate of mutation at minisatellite loci is sufficient to prevent an increase in band sharing in moderately inbred populations. By comparison, hepatic pO2 was not reduced significantly in the B. The double lumen Accura balloon is less expensive, making it an attractive alternative in the developing countries.

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Estimate of the transition point from exponential to Gompertzian growth and potential clinical implications. To determine differences in disease characteristics between the thyroid cancer populations in the area around the Three Mile Island (TMI) nuclear power plant and the rest of the state of Pennsylvania. Thirty-six of these patients were treated with radiation therapy. After a difficult postoperative period with multiple problems, he was eventually discharged home. The aim of the present study was to determine T-helper type 1 and T-helper type 2 cytokine levels in chronic hepatitis C infection. Contemporary concepts regarding the use of laparoscopy in large bowel surgery were presented. Based on our study, it is suggested that inflammation might play a key role in the glyburide dosing in pregnancy pathogenesis of XLRS. Observations were carried out in Gaoligong Nature Reserve (GNR) in China and in the Kanchenjunga Conservation Area (KCA) in Nepal. The authors discuss the implications of these findings for forensic research. A pseudooutbreak of cryptococcal meningitis was caused by the use of contaminated albumin solution used in the preparation of Papanicolaou-stained slides of cerebrospinal fluid.

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For ulcerous hemorrhage the operation of choice was resection of the stomach. To systematically compare different approaches for evaluating mucosal proliferative activity regarding their diagnostic role for delineating flat lesions of the bladder mucosa. 1950-69 WERE SIGNIFICANTLY INCREASED IN COUNTIES WITH COPPER, LEAD, OR ZINC SMELTING AND REFINING INDUSTRIES, BUT NOT IN COUNTIES WHERE OTHER NON-FERROUS ORES ARE PROCESSED. Psychologic profile of tinnitus patients using the SCL-90-R and Tinnitus Handicap Inventory. The term addictive as used by the popular press frequently confuses the more precise concepts of acute and chronic tolerance, physical dependence and withdrawal, and psychologic dependence. A SURVEY RELATING TO THE CAPE COLOURED POPULATION OF CAPE TOWN IN THE YEARS 1961-1962. In 30 patients (15 with normal peripheral vascular status and 15 with peripheral vascular disease, hypertension, or a heavy smoking history), systolic, mean, and diastolic arterial pressures were recorded simultaneously every 5 min using a radial arterial catheter, an oscillometric arm cuff, and a Finapres finger cuff during 1-6 h of anesthesia and operation.

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Aggregation response of human platelets stored at 22 C as platelet-rich plasma. The methodological quality of all studies was poor except for the single RCT study. New bone formation with autografts and allografts determined by Strontium-85. The selective effect of 1-phenylisopropyladenosine against DMCM-induced seizures suggests that adenosine receptor agonists may allosterically counteract the negative modulating effect of DMCM on GABA coupling to the chloride channel. The results revealed that neutrophil chemotaxis and phagocytosis as well as ROS generated in a xanthine-xanthine-oxidase system were not significantly changed in the presence of azelaic acid. Metatranscriptomic analysis provided insights into functional shifts in the murine intestinal microbiota, with increased transcription of genes associated with regulation and cell signaling, carbohydrate metabolism and respiration and decreased transcription of flagellin genes during inflammation. Here, we report a case of the rare but relatively more severe autosomal recessive CMT type 4C disease with a few features that are distinct from its regular presentation. The evaluation was conducted in 2013, over a 12- month time horizon, considering all the procedures carried out using the two technologies. Because embryonic neurons are more sensitive to the effects of target derived factors than adult neurons, the developing nervous system provides a sensitive model for investigating the in vivo actions of target-derived growth factors.

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Verapamil might be of therapeutic value in this clinical setting. However, a solid component showing very high signal intensity on T2-weighted images should also be considered stromal edema in benign or borderline cystadenofibromas. During 2012 and 2013, program group and control group students completed pretest, posttest, and 6-week and 6-month follow-up surveys assessing sexual attitudes and knowledge as well as experiences with assault. The resistant bacteria may be transferred to man also by food-stuff of animal origin (meat, milk, eggs). Although little is written in the American literature concerning soccer injuries, it does appear that the injury potential is much less when compared with that of football. It is postulated that a postbulbar duodenal ulcer occurred in this patient and was mediated by vascular deposition of circulating immune complexes. the consequences of partial lobectomy on the contralateral lobe and the influence of sex steroid hormones on the regeneration process. Phosphate uptake in chemostat cultures of Escherichia coli K-12 subjected to periodic beta-glycerophosphate pulsing: a system for assaying alkaline phosphatase. Bolus dose terlipressin (a vasopressin analogue) has been used successfully in this setting allowing cessation of other vasopressor agents. In this review we offer, through an extensive bibliographical search of the subject over the last 2 years, a view of the state-of-the-art of APS including current criteria for diagnosis, molecular basis, main associated clinical manifestations, management and treatment.

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