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Carditrex (Methotrexate)

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Carditrex is a chemotherapy agent and immune-system suppressant. It is used to treat cancer, autoimmune diseases, and ectopic pregnancy and for medical abortions. Types of cancers it is used for include breast cancer, leukemia, lung cancer, lymphoma, gestational trophoblastic disease, and osteosarcoma.

Other names for this medication:
Alltrex, Beltrax, Biotrexate, Caditrex, Carditrex, Cytotrex, Dermotrex, Folitrax, Imutrex, Merex, Methocip, Methorex, Methotrexate, Metorex, Metrex, Mexate, Neotrexate, Nidtrex, Oncotrex, Onotrex, Plastomet, Remtrex, Rextop, Roxate, Tevatrex, Throtex, Trixilem, Vibzi, Zexate

Similar Products:
Motilium, Azulfidine, Trandate, Clomid, Pepcid

Also known as: Methotrexate


Carditrex is a prescription medication used to improve wakefulness in adults who are very sleepy due to one of the following diagnosed sleep disorders: narcolepsy, obstructive sleep apnea (OSA), shift work disorder (SWD).

Carditrex is used with other medical treatments for this sleep disorder. Carditrex does not take the place of using your CPAP machine or other treatments that your doctor has prescribed for this condition. It is important that you continue to use these treatments as prescribed by your doctor.

Carditrex is in a class of medications called wakefulness-promoting agents. It works by changing the amounts of certain natural substances in the area of the brain that controls sleep and wakefulness.


This section provides information on the proper use of a number of products that contain imipramine. It may not be specific to Carditrex-PM. Please read with care.

Take this medicine only as directed by your doctor to benefit your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (capsules): For depression: Adults—At first, 75 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 200 mg per day, unless you are in the hospital. Some hospitalized patients may need higher doses. Teenagers and older adults—At first, 25 to 50 mg per day using the tablets. Your doctor may adjust your dose as needed and switch you to the capsule form. However, the dose is usually not more than 100 mg per day. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets): For depression: Adults—At first, 75 milligrams (mg) per day. Your doctor may adjust your dose as needed. However the dose is usually not more than 200 mg per day. Some hospitalized patients may need higher doses. Teenagers and older adults—30 to 40 mg per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 100 mg per day. Children—Use and dose must be determined by your doctor. For enuresis (bedwetting): Children 6 years of age and older—At first, 25 milligrams (mg) once a day, taken 1 hour before bedtime. Your doctor may adjust the dose as needed. Children younger than 6 years of age—Use and dose must be determined by your doctor.


If an overdose occurs and you are not feeling well, stop taking the medication immediately. You should seek emergency medical attention or contact your healthcare provider immediately.


Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Carditrex are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


If you take calcium supplements, do not take more than your doctor has prescribed. Taking more calcium than recommended will not provide extra protection for your bones, and may cause serious side effects including kidney stones.

Avoid sitting still for long periods of time during travel while you are taking Carditrex.

This medicine can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

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Assay of androgen binding sites by exchange with methyltrienolone (R 1881). Increasing evidence has indicated that the modulation of intracellular redox states has important aspects to cellular events, such as cellular proliferation, activation, growth inhibition, or death via the regulation of intracellular signal transduction and gene expression. Our observations are consistent with the possibility that IFN signaling regulates p202 levels as well as its nucleocytoplasmic distribution. The Golgi apparatus in the gonadotropes was not cup-shaped but ball-shaped or spherical, and its outer and inner surfaces were the cis and trans faces, respectively. Studies on an interferon from tick-borne encephalitis virus-infected cells (IF). PubMed, EMBASE and the Cochrane Library databases were systematically searched to identify RCTs published up to March 2015 evaluating ibandronate to treat MBD or multiple myeloma. Despite the concern about pathogenicity of enterococci, recent studies point out that food and meat enterococci, especially Enterococcus faecium have a much lower pathogenicity potential than clinical strains. Asymptomatic HeFH subjects exhibit early coronary atherosclerosis directly associated with TCB burden. Changes in physiologic and biochemical values following exertion test in women with and without calcium substitution.

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Cell proliferation was determined using the MTT assay over 72 hours. Comparison of the present structure with the structure of uracil-containing DNA-bound human uracil-DNA glycosylase suggests that for DNA binding and uracil removal D4 employs a unique set of residues and motifs that are highly conserved within the poxvirus family but different in other organisms. Immunohistological studies on alpha1-fetoprotein and alpha1-acid glycoprotein during azo dye hepatocarcinogenesis in rats. Pre-emergency-department care-seeking patterns are associated with the severity of presenting condition for emergency department visit and subsequent adverse events: a timeframe episode analysis. The two indicators gave renographic curves of slightly different shape, those after DPTA being flatter, but estimations of separate kidney function were not significantly different. Further insight into the molecular pathway disclosed that the combination treatment caused upregulation of p53 and Bax and suppression of Bcl-2 followed by the activation of caspase cascade and poly (ADP-ribose) polymerase cleavage.

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Furthermore, it seems that recombination is acting as an important driving force in the evolution of A. Using MRI, we have previously reported in a preliminary study that female patients with eating disorders had significantly smaller pituitary glands than controls. For-hire three-wheeler crashes are a growing burden in Sri Lanka. Microbiome alterations that might contribute to the development of autism include altered immune function and bacterial metabolites. Effector cell specificity to modified cell surface components controlled by H-2K and H-2D serological regions of the murine major histocompatibility complex. A 41-year-old man ingested orally a large quantity of methanol and was found dead at home. BiNP were capable of entering cells in a dose and time dependent manner by fluorescence and element detection methods BiNP were found to be localized in the cytoplasm observed by transmission electron microscopy and intracellular bismuth element confirmed by energy dispersive X-ray analysis. Perceptual evaluation of violins: A psycholinguistic analysis of preference verbal descriptions by experienced musicians. The 3-D models and numerical information support the hypothesis that rice mesophyll cells enhance their CO 2 absorption with increased cell surface and sheet-shaped chloroplasts.


The variables evaluated were severity of pain, bleeding, facial swelling and ease of nutrition experienced by patient during the first 3 days after surgery and inflammation, granulation tissue formation and gingival color at 7 and 14 days. Lipopolysaccharide and opioids activate distinct populations of Mytilus edulis immunocytes. The authors have no conflicts of interest to disclose related to this work. This method can be used to quantify NMR imaging of injured ordered tissues. Restoration of defective cross talk in ssi2 mutants: role of salicylic acid, jasmonic acid, and fatty acids in SSI2-mediated signaling. Analysis of effects of hypothermia on central nervous system responses. Here, we dissect such a network in mouse embryonic stem cells (ESCs). In contrary to anti-CCP, anti-CII-positive patients with RA have increased joint destruction and HAQ score at baseline.

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Some clinical methods are available for qualitatively evaluating the degree of ligament injury and healing. Examination of asthmatic children by serial allergen extract containing skin tests. Treatment with antioxidant NAC significantly reverses detrimental systemic responses in extrapancreatic vital organs by significantly ameliorating neutrophil functions despite ongoing AP. Evidence-based assessment of therapeutic agents of osteoporosis. We currently advocate treatment of symptomatic territory first in favor of staged procedures and reserve combined procedures for patients with critical stenosis or symptoms in both territories. It is concluded that acetohydroxy acid synthase is a target for the toxicity of the high concentrations of leucine brought into Escherichia coli K-12 by leucine-containing peptides. Blood samples were collected on 22nd day from each rat and subjected for evaluation of hematological parameters such as red blood corpuscles (RBC), white blood corpuscles, hemoglobin (Hb) and platelets, and serum biomarkers such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP). Escherichia coli cells carrying fosfomycin resistance plasmids were able to take up fosfomycin from the medium to the same extent as plasmid-free bacteria.

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Therefore, streptokinase side effects must be taken into consideration when being administered for this group of patients. Despite the rapid progress in the definition of adrenocortical stem/progenitor cells in the mouse, the factors that cause the differentiation of adrenocortical cells into zonal cell types have not been identified. Arrestin mRNA levels and protein synthetic rates were high in young rds retinas. The mitral valve of the patient was normally functioning without any other coexistent cardiac abnormalities. Because of the strict Organ Transplantation Act, only 81 brain dead (BD) organ donations had been performed in Japan for 13 years since 1997. A total cystectomy and partial ureterectomy were carried out, and an appendix conduit was constructed because the ureter was not sufficiently long for ureterocutaneostomy. In this prospective cohort study, a total of 104 implants were placed in posterior sites of 51 partially edentulous patients exhibiting bone densities of Class 1, 2, or 3. Sacrificial limbs of sovereignty: disabled veterans, masculinity, and nationalist politics in Turkey. 1137), the Persian physician and philosopher, received his medical training in the most famous schools of the Iranian province of khawarizm.


Effectiveness of written action plans for acute asthma: A systematic review. Results with this enzyme immunoassay using monoclonal antibodies (M-EIA) have been compared with those obtained by the conventional inhibition radioimmunoassay (RIA) using goat antiserum. Five shipments of feeder calves (965 head hauled in 11 drop-center trailers) were shipped 1,600 km by tractor trailer from Algood, Tennessee, to Bushland, Texas, during the fall seasons of 1976, 1977 and 1978. THE INOSINIC ACID PYROPHOSPHORYLASE ACTIVITY OF MOUSE FIBROBLASTS PARTIALLY RESISTANT TO 8-AZAGUANINE. In this paper, we propose a new method for determining Euler angles of projections by applying Genetic Algorithms (i.e., GAs). The effect of inhibitors on the monocytes neutral proteinases showed them to be of the serine type.


Patterns of disclosure of HIV serostatus varied in relation to ethnicity. Here, we conducted two experiments in ovariectomized ewes to determine whether an acute increase in plasma cortisol inhibits pulsatile LH secretion by suppressing GnRH release into pituitary portal blood or by inhibiting pituitary responsiveness to GnRH. More research measuring coverage and other relevant outcomes is urgently needed to inform the design of services delivering PMTCT programs. Treatment of Primary Central Nervous System Posttransplant Lymphoproliferative Disorder in an Adult Kidney Transplant Recipient: A Case Report. RT-PCR was performed for adenine receptor expression in T-6 and primary rat HSC. Although neuro-imaging studies have implicated some regions underlying this disorder, there is little information regarding its large-scale connectivity pattern. Histological examination revealed vasculitis compatible with the diagnosis of toxiderma. Measuring personal exposure to airborne mutagens and nicotine in environmental tobacco smoke. Epidemiological, observational, retrospective and multicenter study carried out at 30 sites throughout Spain. The IMS will serve the output from climate impact models, such that the model results can be customized by the web site user and be most readily applied to the planning and analysis of adaptation strategies.

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Patient feedback showed average ratings for the majority of the BHCs. We compared outcomes of robotic-assisted, laparoscopic, and open surgery in a nationally representative population database. Diverging prevalences and different risk factors for childhood asthma and eczema: a cross-sectional study. A strong therapeutic alliance was associated with fewer difficulties in regulating emotions. However, the two tests had similar diagnostic value in normotensives. Pulmonary scintigraphy as a supplement to radiography--fundamentals and clinical significance. Free radicals are involved in ischemia-reperfusion injury and inflammatory processes. Few hours after discharge from a non-local maternity ward a 3-week-old boy was admitted to our hospital because of GBS meningitis with necrotizing encephalomalacia.

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In this paper, we overcome the limited dynamic range of the conventional digital camera, and propose a method of realizing high dynamic range imaging (HDRI) from a novel programmable imaging system called a digital micromirror device (DMD) camera. Therefore, we surmise that the masticatory function of these mice is different from that of normal mice. Here we present evidence that Cdh1p activity at the M/G(1) transition is important not only for mitotic exit but also for high-fidelity chromosome segregation in the subsequent cell cycle. Within the primate order, adrenarche has been described only in humans and chimpanzees, but bonobos, the sister species of chimpanzees, have not yet been studied regarding the early ontogenetic changes such as adrenarche. Together, our results illustrate that SIX1 is the central mediator of dorsal mandibular arch identity, thus ensuring separation of bone development between the upper and lower jaws.

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EFFECT OF NICOTINAMIDE ON IN VITRO HISTAMINE RELEASE AND SLOW-REACTING SUBSTANCE FORMATION IN ANAPHYLACTICALLY SENSITIZED LUNG AND ITS RELATION TO ACID-SOLUBLE NUCLEOTIDES. Since the smallest apparent subunit was 14,000, the enzyme was presumed to be composed of four subunits. Hormone-regulated networks likely integrate the actions of multiple systemic signals to adjust the activity of stem cell lineages in response to changes in physiological status. We hypothesized that there would be significant variability in logistics related to ancillary staff (i.e. Effects of rheumatoid sera on fibroblast proliferation and hyaluronic acid synthesis.


Spray-coating route for highly aligned and large-scale arrays of nanowires. it represented a relatively large portion of the total cellulase activity, and may play an important role in the degradation of native cellulose in vivo. Effect of the method of heart preservation on hemodynamics of the transplanted heart with the original heart still in place. Use of determinations of 7-lathosterol (5 alpha-cholest-7-en-3 beta-ol) and other cholesterol precursors in serum in the study and treatment of disturbances of sterol metabolism, particularly cerebrotendinous xanthomatosis. The results are discussed in terms of the possible role of granulocytes in bovine hypersensitivity. baumannii isolates and was re-established after genetic complementation. (Nitronyl nitroxide)-substituted trioxytriphenylamine radical cation tetrachlorogallate salt: a 2p-electron-based weak ferromagnet composed of a triplet diradical cation.

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INFLUENCE OF THYROXIN ON THE MITOCHONDRIAL CONTENTS OF THYMIC AND LYMPH NODE CELLS. Intraventricular noradrenaline had a stimulating effect on the synthesis and secretion of LH-RH in both intact and castrated animals. Exudative macular detachment caused by a lopressor drug classification small noncalcified retinal astrocytic hamartoma confirmed by optical coherence tomography regressed completely after laser therapy. However, there are currently very few reports of early SCC of the anal canal resected by endoscopic submucosal dissection (ESD). The behaviour of some biologic parameters in obese patients after short-term exercise under restrictive diets. The gingival contour was significantly improved and no sign of recurrence was noted up to 4 years later. Deficits in PPI and N40 gating appeared most pronounced in rats with larger lesions, focused within the ventral hippocampus.

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The subset identity of T lymphocytes participating in the leucocyte adherence inhibition (LAI) reaction was investigated. This review demonstrates the major and novel NMR methods and techniques used in understanding and characterizing the different microemulsion components, types and structures. Comparison of four tests of quadriceps strength in L3 or L4 radiculopathies. C-reactive protein has a better discriminative power than white cell count in the diagnosis of acute cholecystitis. To evaluate the effect of WRGJ and RW intake and resveratrol solution (RS) on blood pressure and fat liver deposition of rats fed with high-fat diet. We found that habitual consumption of an HP diet can reduce the negative effect of phytate on nonheme-iron absorption among young women with suboptimal iron stores. Subgroup analyses were conducted to identify potential effect modifiers. Alcian Blue staining in MgCl-2 of various concentrations revealed that the basement membrane of dog hair follicles contains a large amount of glycosaminoglycan that increases with age, varies with breed, and is significantly greater than that of dermal collagen.

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Some observations on evaluating the progress of severely retarded or trainable children in a school program. Imaging modalities are useful for characterization of patellar malalignment, maltracking, underlying morphologic abnormalities, and stabilizing soft-tissue injuries. Determination of the hydaluronidase activity in combination with equal parts of 2-(beta-chloroethyl)-2,3-dihydro-4-hydroxy-(benzo-1,3-oxazine) and 1,4-diphenyl-3,5-dihydroxypyrazolidine. The mechanisms underlying zithromax antibiotic how to take different types of obesity have been gradually clarified. Vegetative equilibrium disorders in hypertensive-diseased miners resulted from pathologic developments in the limbic -reticular structures. The role of postoperative radiotherapy in N- breast cancer with centrally or medially located tumors is still controversial. Study on the effects of different risk stratifications in patients with diabetes mellitus: a clinical endpoint event. Two polymorphic sites in the FoxP3 promoter (rs3761548 and a (GT) n -dinucleotide repeat) and 2 single nucleotide polymorphisms in intron 1 of the Vav1 gene (rs2546133 and rs2617822) have been shown to correlate with gene expression levels. No change in calcium absorption in adult Pakistani population before and after vitamin D administration using strontium as surrogate. Traumatic cervical syndrome treated by liberation of the vertebral artery and uncusectomy.

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Duplication of the LMNB1 gene encoding lamin B1 nifedipine adalat cc 30 mg 24 hr tablet causes adult-onset autosomal-dominant leukodystrophy (ADLD) starting with autonomic symptoms, which are followed by pyramidal signs and ataxia. Relationships between microfilaments, cell-substratum adhesion, and fibronectin. This review will consider the development and standardization of sample preparation methods applicable to MSI, describing the stages and procedures undertaken from the instance of sample collection, through storage, preparation and on through final processing prior to analysis. Insulin treatment of diabetic rats increased the enzyme activity by 7-fold. Production of nitraminoacetic acid by Streptomyces noursei 8054-MC3. Pre-ESRD Dementia and Post-ESRD Mortality in a Large Cohort of Incident Dialysis Patients. This study is the first to report that propionic acid exists in S. Longer follow-up period is required to detect any further regression. Because the capacity of RNA-Seq data for network construction has not been previously evaluated, we constructed a coexpression network using striatal samples, derived its network properties and compared it with microarray-based networks.

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Increasing the length of NF-M lodine 300 mg fiyat 2021 C terminus in mice increased diameter of motor axons without altering neurofilament subunit stoichiometry. Using a radioactive cDNA probe, we localized the GHRF gene to chromosome 20p12 or near band 20p12. Taken together, ovolin may exhibit anxiolytic-like activity in a manner dependent on the PGD2 -DP1 system coupled to the A2A and GABAA receptors. Preparation of malathion MIP-SPE and its application in environmental analysis. Meeting of the Study Group on Hemostasis and Thrombosis, Clamart (France), 26 November 1977. The expression of the S gene was detected by Northern blot hybridization, Western blot hybridization, and enzyme-linked immunosorbent assay (ELISA), respectively.

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Cell adhesion and movement in relation to the developing limb pattern in normal and talpid mutant chick embryos. The care of amputation stumps by osteo-myeloplastic according to v. enterica serovar Typhimurium is a surveyed worldwide serotype with well-characterized genomes for several different strains. A case report and the role of radiologic imaging modalities in diagnosing this entity is presented. Even the use of this restricted dataset yields results whose validity is not beyond question. Guidelines for clinical management of bioterrorism bacterial diseases: anthrax, plague, turalemia and brucellosis. Early sexual use and its effect on the sexual function, development, and duration of usefulness of spotted moutain breed bulls.

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The bioavailability parameters were obtained from urinary I excretion. Acetate, F-, SO4(2-) and PO4(3-) were not found to have significant inhibitory properties. Serum from each patient was characterized in isolated rabbit hearts where ECG parameters were analyzed. Simultaneous determination of imipramine and amitryptiline by derivative spectrophotometry. Good viability of follicles was confirmed when using propanediol and sucrose as cryoprotectants, with a large number of follicles. Thirty-three university-affiliated centers, including Veterans Affairs, community, and municipal hospitals. Collection of trace amounts of DNA/mRNA molecules using genomagnetic nanocapturers. Both a single dose of 1 mg ketotifen and 4 weeks treatment of ketotifen, 1 mg twice daily, failed to reduce the methacholine-induced drop in peak expiratory flow.

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Functionalized membrane supports for covalent protein microsequence analysis. A short incision may reduce wound complications but may compromise the arteriovenous (AV) function because of the shorter length of femoral vein available for puncture. By integrative analysis of chromatin immunoprecipitation-sequencing (ChIP-seq) and microarray expression profiling data, miRNAs putatively bound and significantly regulated by AR were identified. The negative consequences of calcium-dependent mitochondrial activation can be ameliorated when the underlying cytosolic calcium signals occur as brief calcium spikes or oscillations, with signal strength encoded through the spike frequency (frequency modulation). Evaluating a complex intervention: a process evaluation of a psycho-education program for lung cancer patients receiving palliative radiotherapy. Diagnostic catheterization showed a large left anterior descending coronary artery to pulmonary artery fistula with impaired left ventricular wall motion. The relationship between force platform data and radiographic OA score was evaluated on 2 separate days using regression analysis. Compound 21 demonstrated robust acute and chronic regulatory effects on glycemic parameters in the diabetic or non-diabetic rodent models. Coronary artery bypass surgery in young adults: excellent perioperative results and long-term survival. The pattern of grey matter decrease is similar to brain alterations seen in schizophrenia.

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