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Cozaar (Losartan)

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Cozaar is hypotension medication which specifically blocks angiotensin II receptors, decreases the total peripheral resistance, concentration of aldosteron in blood, arterial pressure, pressure in pulmonary circulation, and has a diuretic effect. The medication is used to treat hypertension, left ventricular hypertrophy (increase in muscle) and diabetic nephropathy.

Other names for this medication:
Acetensa, Angibloc, Angioten, Cardoplus, Covance, Cozaarex, Fensartan, Fortzaar, Forzaar, Lohyp, Lortaan, Losar, Losardil, Losavik, Losium, Lospre, Lostat, Lozatan, Medzar, Normatens, Ostan, Resilo, Sarve, Satoren, Tarnasol, Temisartan, Tensiohess, Tiasar, Zartan

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Also known as: Losartan


Cozaar (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Cozaar is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Cozaar is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Cozaar 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Cozaar 25 mg, Cozaar 50 mg, and Cozaar 100 mg may also contain carnauba wax.


Take Cozaar tablets orally with or without food. Do not crush or chew it. Take Cozaar once or twice a day at the same time. If you want to achieve most effective results do not stop taking Cozaar suddenly.


If you overdose Cozaar and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Cozaar overdosage: fainting, feeling lightheaded, rapid heartbeat.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

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The most common side effects associated with Cozaar are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Cozaar as soon as possible.

In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with Cozaar. Correct volume or salt depletion prior to administration of Cozaar.

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Report of a visit to the Rehabilitation Services of the city of Edinburgh. Gastrin-like peptides in the amphibian brain: an immunohistochemical study. Thirty plaster models with permanent dentition that met the inclusion criteria were selected and scanned with two laser scanners (R700 and Xcad). The intermediate stage aims at a sustainable and economically profitable reduction of disease burden, while higher stages target elimination. Reconstruction of the masticatory system in congenital oligodontia - a case report (II). Effect of cations on structure-linked sedimentability of lysosomal hydrolases.

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Matrix effect in bio-analysis of illicit drugs with LC-MS/MS: influence of ionization type, sample preparation, and biofluid. Whole body hybrid PET/MRI allowed for the identification of BAT, with a low prevalence, comparable to previous retrospective PET/CT studies realised in the absence of a cooling protocol. In Japan, pegylated IFN (PEG-IFN) is just approved for patients with HBV related chronic hepatitis. The existing highly toxic chemotherapeutic regimens, lack of new congeners with significant efficacy, and drug resistance to cancer cells have prompted scientists to manipulate conventional treatments. The results were compared to the clinical parameters such as--type of cholesteatoma (pars flaccida or tensa), presence of ear discharge, degree of ossicular destruction and involvement of attic and mastoid. Extracellular Cyclophilin A, Especially Acetylated, Causes Pulmonary Hypertension by Stimulating Endothelial Apoptosis, Redox Stress, and Inflammation. The mechanism of sensitivity to phleomycin in growing Escherichia coli cells. acidophilus and then infected with SesE was significantly higher than that in cells infected with SesE without pretreatment. Sirolimus proved to be effective in children with complicated lymphatic or lymphatico-venous malformations and kaposiform hemangioendotheliomas.

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Effects of various histone fractions on the natural resistance of mice to infection. Monte Carlo-based treatment planning system calculation engine for microbeam radiation therapy. subtilis does lunesta show up on a drug test and form dynamic helical filaments underneath the cell membrane. Selective delay activity in the cortex: phenomena and interpretation. Asthma was associated with higher levels of component sensitization, and sensitization to more than one component from the same animal conferred the greatest risk. Both genotyping and phenotyping approaches have been adopted for HIV-1 drug-resistance testing and enable rational modification of therapies for patients in whom their current regimens are failing. In the study reported herein, we describe application of a novel, portable device for measuring the accumulation of magnetizable particles in the lungs of factory workers. Simultaneous with the continuous measurement of tissue pH, the overall acid-base balance of the animal was measured discontinuously at 5-min intervals by means of indwelling arterial and venous catheters. DECREASED INTOXICATION BY FLUOROURACIL WHEN SLOWLY ADMINISTERED IN GLUCOSE.

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This type of intraseptal nasal obturator is comfortable and can alleviate symptoms created by nasal septal defects. There is a need for software tools that enable users to easily and quickly create, revise, extend, review and share code sets and we provide a list of recommendations for their design and implementation. Partner notification and the control of human immunodeficiency virus infection. Undetectable anti-TNF drug levels in patients with long-term remission predict successful drug withdrawal. Melatonin produces a great variety of effects in human organism and plays an essential role in normal function of the body. Metabolism of magnesium and its role in the mechanism of action of cardiovascular agents (review of the literature). Radiographic characterization of diaphragmatic excursion in halothane-anesthetized ponies: spontaneous and controlled ventilation systems.

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After learning without a masking procedure, the GNG creates clear averages of the inputs as unit coordinates in multi-dimensional space, which are then utilized for classification. The aim of this study was to assess the prevalence and associated factors of tuberculosis treatment failure, death and default among hazardous pepcid dosage pregnancy or harmful alcohol users. 18 women had evidence of tissue depletion of vitamin B6, although all the women had abnormal tryptophan metabolism, including increased urinary xanthurenic acid (X.A.) excretion. A novel immunochemical technique for a specific enzymic determination of the myocardial isoenzyme of creatine kinase, CK-MB, involves determination of B-subunit activity of a specimen in which the M-subunit activity has been inhibited by specific antibodies to the M-subunit. Use of CHX gel for cord care in neonates is likely to be acceptable to health care workers in settings with high prevalence of neonatal morbidity and mortality arising from cord infections. In homes, the major triggers of allergy and asthma are the house dust mites Dermatophagoides farinae and D.

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Homosexuality, though more than 20 years no longer exists in the classification of diseases as a deviation, it is still by many people seen as such behavior. On the distribution of the LDH isoenzyme in serum of patients with psoriasis. Future meta-analyses of diseases and traits with multiple known genetic associations can use this approach to identify outlier studies and thereby optimize power to detect novel genetic associations. Continuation of antisecretory drug therapy beyond a one-week low-dose triple therapy consisting of omeprazole, clarithromycin and tinidazole is actually excessive regarding eradication efficacy and peptic ulcer healing. An increase in blood pressure at the venous end of the capillary induced an interstitial-fluid volume increase, which, in turn, reduced negative tissue pressure to prevent edema. Prevalence of psychosis in tuberculosis patients and their nontuberculosis family contacts in a multidrug treatment-resistant treatment center in Nigeria. THE NEGLECTED CHILD: COLLABORATIVE APPROACHES TO RECOGNITION AND MANAGEMENT. After giving pentoxifylline to patients with asthenozoospermia for 3 months, sperm motility significantly increased, but sperm concentration did not increase.

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One class of cells respond to long wavelength (visible) stimuli with a depolarizing receptor potential and to near ultraviolet light with a biphasic, initially hyperpolarizing, receptor potential. The demographic data, clinical symptoms, opening pressure, pre-operative and post-operative visual fields, neuroimaging, visual acuity, disc status, and complications were recorded and analyzed. The influence of unlabelled glucose (6 mM) and insulin on substrate utilization by adipocytes was also studied. Activation with trypsin imparted to the enzyme the ability to hydrolyze collagen at neutral pH in a typical manner and to form an inhibited complex with alpha2-macroglobulin. A single protein was purified and identified by mass spectrometry as H. STUDIES ON THE EFFECTIVENESS OF ALKALI-GLUCOSE INFUSIONS IN PROLONGED ACIDOSIS IN PREMATURE AND NEWBORN INFANTS. Characteristics, sources and health risk assessment of toxic heavy metals in PM2.5 at a megacity of southwest China. Chromosomally-mediated beta-lactamases are generally inducible and have a high activity against cephalosporins. Evidence that the 37 kDa protein of Soil-borne wheat mosaic virus is a virus movement protein. The formation of covalent hybrid structures depends upon a functional reverse transcriptase in vivo, since its appearance in cells is temperature dependent when infected with Rous sarcoma virus mutant LA335, which contains a temperature-sensitive reverse transcriptase.

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