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Klonopin (Clonazepam)
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Klonopin

Klonopin is one of the products that belong to the bensodiazepine group and have a strong sedative effect. It is widely used among people with severe panic attacks and anxiety caused by depression treatment. Thanks to its unique features, Klonopin helps to stop convulsions and epileptic seizures.

Other names for this medication:
Adnil, Clonapax, Clonark, Clonatrac, Clonaxyl, Clonoasig, Clonopam, Clonotril, Clonzy, Closis, Clotas, Clozep, Dipwell, Ection, Eminaz, Esitor, Estalonix, Lonazep, Nazee, Prasilex, Prasilife, Revozip, Rivotril, Sezolan, Sezolep, Somnotril, Xenotril, Zepam, Zeptril

Similar Products:
Altace, Wellbutrin, Cordarone, Levlen, Robaxin, Casodex, Buspar, Indocin, Retin

Also known as: Clonazepam

Description

{name} (clonazepam) is a benzodiazepine. It is thought that clonazepam works by enhancing the activity of certain neurotransmitters in the brain. Clonazepam is also a seizure medicine, also called an anti-epileptic drug.

{name} is used to treat certain seizure disorders (including absence seizures or Lennox-Gastaut syndrome in adults and children.

{name} is also used to treat panic disorder (including agoraphobia) in adults.

Dosage

Klonopin is indicated for the treatment of panic disorder, with or without agoraphobia, as defined in DSM-V. Panic disorder is characterized by the occurrence of unexpected panic attacks and associated concern about having additional attacks, worry about the implications or consequences of the attacks, and/or a significant change in behavior related to the attacks.

The efficacy of Klonopin was established in two 6-to 9-week trials in panic disorder patients whose diagnoses corresponded to the DSM-IIIR category of panic disorder.

Panic disorder (DSM-V) is characterized by recurrent unexpected panic attacks, ie, a discrete period of intense fear or discomfort in which four (or more) of the following symptoms develop abruptly and reach a peak within 10 minutes: palpitations, pounding heart or accelerated heart rate; sweating; trembling or shaking; sensations of shortness of breath or smothering; feeling of choking; chest pain or discomfort; nausea or abdominal distress; feeling dizzy, unsteady, lightheaded or faint; derealization (feelings of unreality) or depersonalization (being detached from oneself); fear of losing control; fear of dying; paresthesias (numbness or tingling sensations); chills or hot flushes.

The effectiveness of Klonopin in long-term use, that is, for more than 9 weeks, has not been systematically studied in controlled clinical trials. The physician who elects to use Klonopin for extended periods should periodically reevaluate the long-term usefulness of the drug for the individual patient.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, or coma.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Side effects

The most common side effects associated with Klonopin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Before taking Klonopin,

tell your doctor and pharmacist if you are allergic to Klonopin, other benzodiazepines such as alprazolam (Xanax), chlordiazepoxide (Librium, in Librax), clorazepate (Gen-Xene, Tranxene), diazepam (Diastat, Valium), estazolam, flurazepam, lorazepam (Ativan), midazolam (Versed), oxazepam, temazepam (Restoril), triazolam (Halcion), any other medications, or any of the ingredients in Klonopin tablets. Ask your pharmacist for a list of the ingredients.

tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: amiodarone (Cordarone, Nexterone, Pacerone); certain antibiotics such as clarithromycin (Biaxin, in Prevpac), erythromycin (Erythrocin, E-mycin, others), and troleandomycin (TAO) (not available in the US); antidepressants; certain antifungal medications such as itraconazole (Onmel. Sporanox) and ketoconazole (Nizoral); antihistamines; certain calcium channel blockers such as diltiazem (Cardizem, Tiazac, others) and verapamil (Calan, Covera, Verelan, in Tarka); cimetidine (Tagamet); HIV protease inhibitors including indinavir (Crixivan), nelfinavir (Viracept), and ritonavir (Norvir, in Kaletra); medications for anxiety, colds or allergies, or mental illness; other medications for seizures such as carbamazepine (Epitol, Tegretol, Teril), phenobarbital, phenytoin (Dilantin, Phenytek), or valproic acid (Depakene); muscle relaxants; nefazodone; rifampin (Rifadin, Rimactane); sedatives; certain selective serotonin reuptake inhibitors (SSRIs) such as fluvoxamine (Luvox); other sleeping pills; and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

tell your doctor what herbal products you are taking, especially St. John's wort.

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Short-term treatment with rapamycin and dietary restriction have overlapping and distinctive effects in young mice. Prevention of heavy maternal alcohol use has the potential to reduce stillbirths. Ultrasound evaluation of the normal and abnormal fetal neural axis. We show how to efficiently calculate the signal in optical coherence tomography (OCT) systems due to the ballistic photons, the quasi-ballistic photons, and the photons that undergo multiple diffusive scattering using Monte Carlo simulations with importance sampling. These include allocating sufficient time and resources to tailor presentations for diverse tribal settings and workshop participants, addressing barriers to participation in clinical trials through culturally appropriate strategies, providing information to foster informed decision making related to participation, and writing as a team to increase cultural breadth of examples and interactive experiences.

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A novel electroless Pt deposition method was exploited by employing the galvanic replacement process occurring between the Mn(3)O(4) surface and PtCl(4)(2-) complexes. These features and the finding of a predominantly sinusoidal infiltrate of neoplastic cells on liver biopsy raised the suspicion of malignant histiocytosis. From January 2008 to May 2012, we have included all patients over the age of 16 years which featured a systemic scleroderma meeting the criteria for classification of Leroy and Medsger modified. Peptide inhibitors that target a specific sequence of NADPH oxidase components could be more specific than small molecules. In Saccharomyces cerevisiae, mating pheromone-induced death 1 (MID1) encodes a component of a putative calcium channel. The Wellness-Program contributed considerably to improved health and well-being of the women. Patterns of regional cerebral blood flow associated with low hemoglobin in the Baltimore Longitudinal Study of Aging. Branching patterns of the rat phrenic nerve during development and reinnervation.

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Topological similarities in dehydrogenases may reflect an ancient divergence or merely chemical constraints on protein architectures. Hydrogenolysis of neutral silver fluorides affords hydride-bridged disilver cations as their bifluoride salts. Two cholecystokinin receptor subtypes are identified in goldfish, being the CCKAR involved in the regulation of intestinal motility. Ethanol-associated selective fetal malnutrition: a contributing factor in the fetal alcohol syndrome. Higher dietary phosphorus absorption is associated with higher urine DA in humans, consistent with animal models. In case of non-regional lymphatic spread, left supraclavicular region was found to be the most common site (1,2,3) whereas right sided metastatic lymph node involvement has been extremely uncommon. Hidden from health: structural stigma, sexual orientation concealment, and HIV across 38 countries in the European MSM Internet Survey. This finding suggests that the first exposure provides a degree of protection for the surviving hair cells, perhaps by uncoupling them from the TM.

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The preferred surgical approaches to subtalar fusion are the sinus tarsi incision, the medial incision, and the extensile lateral approach. The most serious toxicity involves the cardiovascular system and the central nervous system. Some DH locations, such as the inferotemporal quadrant and the cup margin, were associated with RNFL defects, whereas others were not. We conclude that OPCAB is safety performed in a patient with malignant diseaes. Effect of clofibrate on insulin release from rat Islets of Langerhans. Evaluation of Urinary Aquaporin 2 and Plasma Copeptin as Biomarkers of Effectiveness of Desmopressin Acetate for the Treatment of Monosymptomatic Nocturnal Enuresis. Streptococcus behaves similarly in that wholly homologous (streptococcal) DNA transforms it more efficiently than when the transforming fragment contains a pneumococcal moiety. The present functional magnetic resonance imaging study investigated the specialization and integration of dorsal and ventral streams using tasks of object recognition and location detection. Lisuride, when used alone, has definite antiparkinsonian activity and is a promising new drug. To study the effect of preoperative selective portal vein embolization (SPVE) in the two-step hepatectomy for patients with primary hepatocellular carcinoma (HCC) in injured livers.

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The sugar-stimulated binding of enzyme IIIglc was concluded to the specific to the lactose permease because it (i) was dependent on the amount of the permease, (ii) was promoted only by sugar substrates of the permease, and (iii) was completely eliminated by treatment of the membranes with N-ethylmaleimide in the absence (but not the presence) of thio-beta-D-digalactoside. The deposits in the dermo-epidermal junction are similar to those seen in the skin of patients with systemic lupus erythematosus. On the basis of our data, higher BED does not seem to be a predictor of response or of duration of response in the palliative treatment of renal cell carcinoma. Effects of amino acids, adenine nucleotides and inorganic pyrophosphate on glutamine synthetase from Anabaena cylindrica. A total of 7,260 seedlings germinated from these nuts were examined as to their leaf structure.

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As we debate policy and plan interventions using contemporary census data, it may be useful to remind ourselves of the issues, then and now. Splenic abscess caused by Streptococcus anginosus following laparoscopic sleeve gastrectomy: a case report of a rare complication of bariatric surgery. Blood acceleration is the principal factor in coronary flow increase during exercise test. Because of the rarity of IMSCT, there is little information about postoperative neuropathic pain after surgical resection. In particular, the masseter muscle is highly specialised, having extended anteriorly to originate from the rostrum. Multidimensionality of state and trait anxiety: factor structure of the Endler Multidimensional Anxiety Scales.

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Novel mutations in the PEX12 gene of patients with a peroxisome biogenesis disorder. Hence the study of CTCs is not only instrumental as a basic research tool, but also allows the serial monitoring of tumor genotypes and may therefore provide predictive and prognostic biomarkers for clinicians. Fungistatic properties and skin tolerance of some rhodanphenols, rhodanphenol-ethers and rhodanphenol-ketones. The anomalies are explained by the observation that the 2 x 2 tables exhibit differential misclassification. Two of the major statistical and methodological issues relevant to the selection of dependent variable(s) are statistical power and social utility. A random sample of comments about Quebec dentists made in 2011 was extracted from the public website RateMDs.com. Imipenem/cilastatin: evolution of the sustained-release intramuscular formulation. Difference in oxidative stress tolerance between rice cultivars estimated with chlorophyll fluorescence analysis.

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The findings suggest that a low level of genetic variation for bamylgene within climatic zones is associated with individual breeding program for each climatic zone. Two patients with Stage 5 chronic kidney disease (CKD) developed progressive hallucinations, asterixis, myoclonic jerks, and cognitive impairment after receiving the recommended dose reduction for CKD of ertapenem (500 mg/d) for 4 days (Case 1: acute cholecystitis) and 5 days (Case 2: arteriovenous fistula infection). Out of 5546 cadaveric kidneys, transplanted in the Eurotransplant area in the past ten years, 149 were from donors over 50 years of age. Severe vinblastine-induced leukopenia during late pregnancy with delivery of a normal infant. Relationship between daytime variability of blood pressure or ocular perfusion pressure and glaucomatous visual field progression. For obstructed hemivagina in a newborn, expanding fluid collections may be addressed with a drain to avoid mass effect and to aid in the diagnosis. Altered Competitive Fitness, Antimicrobial Susceptibility, and Cellular Morphology in a Triclosan-Induced Small-Colony Variant of Staphylococcus aureus.

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High serum selenium concentrations in reindeer breeding Lappish men. The AChE levels in both patient groups were unrelated to the degree of cognitive decline and they were in the same range as in the control group. Very high resolution single pass HLA genotyping using amplicon sequencing on the 454 next generation DNA sequencers: Comparison with Sanger sequencing. In IVF-ET treatment, acupuncture and moxibustion affect estrogen level on hCG day, improve high-quality embryo rate, endometrial blood flow state and morphology so that the endometrial receptivity is increased and the method is expected to be the assistant therapeutic approach for the improvement of IVF-ET outcome. The insensitivity of glioma to standard therapies combined with the hypothesis that glioma stem cells (GSCs) are responsible for this chemorefractory nature suggests that investigations exploring the function and mechanism of miR-34a in GSCs would be of value. Mechanism of action (MOA) studies using cellular and biochemical assays coupled with 3D fingerprinting and in silico modeling demonstrated that these drug-like probe compounds exert their effects by inhibiting the viral reverse transcriptase polymerase (RT). Experiences with local terramycin administration in trichomonas vaginitis. The rabbit muscle phosphorylase obtained from the bacterial expression system is enzymatically identical to the enzyme purified from rabbit muscle.

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Moreover, membranes of the mutant were found to contain demethyl-menaquinone and, in place of ubiquinone, a structural analogue, 2-octaprenyl-3-methyl-6-methoxy-1,4 benzoquinone. Peroxiredoxin-1 protein may be associated with cleft palate in mice induced by TCDD. Serial ultrasonography showed significant reduction in buckle height over 6 months in both groups to an equal degree. The participation in the re-entry programmes led to enduring improvements in independent living and productive activities. A simple method is proposed and analysed which explains characteristic manifestation of the enchancement effect (2nd Emerson effect) and of chromatic transients effect (Blinks effect). The communication process and its application to medical technology education. Data analyses were performed with Kruskal-Wallis one-way analysis of variance and linear regression. Measures of renal function in patients with cisplatin-related chronic renal disease. Secondary endpoints were time required for successful intubation, the amount of dental stress exerted during laryngoscopy and satisfaction with each airway device.

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Mitomycin-C in dacryocystorhinostomy: From experimentation to implementation and the road ahead: A is the medicine singulair a steroid review. elegans is a powerful model with which to study ciliary EV biogenesis in vivo and identify cis-targeting motifs such as myristoylation that are necessary for EV-cargo association and function. In case 2, tuberculosis was ruled out by tissue and faecal polymerase chain reaction and culture. Four years of clinical experience with the cardio-eurhythmic action of verapamil in intravenous administration. We studied clinical and surgical details of extramedullary tumors located in the region of the foramen magnum. T-cell lines, CCRF-HSB-2 and SOMMER-T (number 8402), gave small but significant stimulation to allogenic lymphocytes especially in the presence of foetal calf serum. Electromagnetic fields (EMFs) used in stem-cell tissue engineering can help elucidate their biological principles. The main findings are that the relative infectiousness of infected animals in this outbreak becomes appreciable early into disease incubation and that the mean incubation period is less than 1.5 years. The effect of combinations of these agents was determined by agar incorporation tests and by time-kill studies. Bony resorption was a characteristic radiogram finding in a series of 25 cases of dumb-bell orbital dermoid, and a definitive diagnosis of the nature and locality of the tumor could be done by ultrasonography, CT, or MRI.

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Reevaluating the imaging definition of tumor progression: perfusion MRI quantifies recurrent glioblastoma tumor fraction, pseudoprogression, and radiation necrosis to predict survival. Chronic ventilation in infants with surfactant protein C mutations: an alternative to lung transplantation. (rape) bee pollen treated with protamex hydrolysis, ultrasonication, and combination of protamex hydrolysis and ultrasonication. The N1 components of the VEP and AEP had distributions compatible with sources in and near the respective primary cortical projection areas. The antihypertensive effects of hydrochlorothiazide and spironolactone when added to treatment with metoprolol were compared in a double-blind trial comprising 55 previously untreated patients with essential hypertension. The PCSK9 p.R46L LOF variant was not associated with impaired glucose homeostasis in humans.

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In the last decade, minimally invasive endothermal ablation techniques have replaced surgery for the treatment of superficial venous insufficiency to reduce postoperative complications and recovery time and to improve quality of life. NFC technology has emerged recently, and consequently not much academic data are available yet, although the number of academic research studies carried out in the past two years has already surpassed the total number of the prior works combined. The two most abundant metabolites (one mono- and one bishydroxylated product) were structurally confirmed by LC/ESI-HRMS and NMR. However, whether decreased expression of CYFIP2 contributes to gastric carcinogenesis remains unclear. Studies showed pain measures improved or did not worsen compared to controls, but methodological quality was moderate and results need cautious interpretation.

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