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Koncal (Calcitriol)
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Koncal

Koncal is a synthetic version of Vitamin D3 used to treat calcium deficiency with hypoparathyroidism (decreased functioning of the parathyroid glands) and metabolic bone disease in people with chronic kidney failure.

Other names for this medication:
Actical, Alfarich, Apcical, Arachitol, Aristrol, Biocal, Biocitral, Calcibest, Calcicare, Calcigra, Calcor, Caldikind, Caldix, Calfa, Calosto, Calotec, Caltive, Caltop, Calzem, Carcal, Cholical, Coecoral, Fovit, Ikmag, Laretol, Minroset, Nutribone, Osteobel, Politrol, Refirm, Rical, Rolsical, Sunmic, Vezocal

Similar Products:
Pyridium, Lunesta, Prometrium, Sildigra, Decadron, Indocin, Dilantin

Also known as: Calcitriol

Description

Generic Koncal is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Koncal are intestine and bone. Generic Koncal receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Koncal may also act on the kidney and the parathyroid glands. Generic Koncal is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Koncal has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Koncal, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Koncal in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Koncal produces other independent beneficial effects. Koncal is also known as Calcitriol. Generic Koncal treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Koncal is Calcitriol. Brand name of Generic Koncal is Koncal.

Dosage

Generic Koncal is available in capsules (0.25 mcg) and liquid form. Capsules must be swallowed whole. Do not crush or chew them. If you are prescribed the liquid form, use as directed. Follow dosing instructions closely. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. If you want to achieve most effective results do not stop taking Generic Koncal suddenly.

Overdose

If you overdose Generic Koncal and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Koncal are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Generic Koncal if you are allergic to Generic Koncal components. Do not take Generic Koncal if you are pregnant, planning to become pregnant, or are breast-feeding. It is not known if this medication appears in breast milk. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Be careful with Generic Koncal if you have heart disease, kidney disease or kidney stones, coronary artery disease (hardening of the arteries). Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. It can be dangerous to stop Generic Koncal taking suddenly.

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On the pathogenesis and morphology of disorders of brain blood supply in diseases of the carotid and vertebral arteries. Developed by a European Association for Palliative Care Task Force, based on literature searches, international expert workshop, development of outcome measurement guidance and international online survey. The present patent review describes recent innovations in the treatment of OSAHS related to optimization of the positive pressure delivered to the patient, methods and systems for continuous self-adjusting pressure during inspiration and expiration phases, and techniques for electrical stimulation of nerves and muscles responsible for the airway patency. Simplification of complex physiologically based pharmacokinetic models of monoclonal antibodies. Triadin in the high salt hydroxylapatite extract could also be immunoprecipitated by a monoclonal antibody to the junctional foot protein.

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Evaluating a web-based clinical decision support system for language disorders screening in a nursery school. However, we observed no resistance associated mutations in the other genes studied, and selection with STR did not result in variants resistant to ERY and vice versa. Do autonomic cardiovascular reflexes predict the nocturnal rise in blood pressure in obstructive sleep apnea syndrome?. These data suggest the possibility that increases in circulating or tissue angiotensinogen may cause an increase in blood pressure in humans, even in the presence of a functionally active servo-mechanism to down-regulate HREN expression. The objective of the study was to introduce the availability of bold imaging facility at Aga Khan University Hospital Karachi for the first time in Pakistan and also to review the practical application and advantages of functional magnetic resonance imaging (fMRI) and blood oxygen level dependant (BOLD) Imaging Procedures. It has been realized for some time that the visual system performs at least two general sorts of motion processing. Information on burnout and somatic complaints (known to be a general marker of stress) was collected through a self-report questionnaire. Using mouse strains C57BL/6J (B6) and C3H/HeJ (C3H), which differ markedly in susceptibility to atherosclerosis, we determined whether variation in subendothelial retention of apolipoprotein B (apoB)-containing lipoproteins constitutes a genetic component in atherosclerosis. To examine frequency and predictors of severe adverse life events and depressive symptoms among HIV-infected women and a comparison group of uninfected women. The frame shift mutation Gly94(insG) combines a loss of function like in the common deletion HNPP with a mild CMT1 phenotype, likely inducing a (mild) toxic gain of function by disturbing myelin formation and maintenance, comparable to the effect in missense mutations.

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In Study 2, undergraduates similarly took three shortened SAT II Subject Tests. In conclusion, a well-performed MRA with specific postprocessing provides an accurate method for mapping perforator vessel, at the same time avoiding ionizing radiation. The phenotype of flat colorectal adenomas differs macroscopically and histologically from exophytic adenomas. Symptoms Moderating the Association Between Recent Suicide Attempts and Trauma Levels: Fan-Shaped Effects. P-glycoprotein (PGP) is well known because of its contribution to multiple-drug resistance during anticancer treatment. The development of aneurysm at the Blalock-Taussig shunt, dilated two years before is described. The HVR quasispecies varied over time both in treated and untreated patients.

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The patterns in the use of dental services by age of patients continue to change. A systematic review of published literature was conducted using two bibliographic databases and two trial registers. Cobalt nanoparticle-loaded Y-type zeolite (HSZ390HUA) without outer-surface Co aggregates is successfully prepared by Co impregnation reaction followed by surface treatment using tetraethylammoniumbromide having larger molecule size than the orifice size of the Y-type zeolite. Lastly, we propose that the radiology report includes not only the type but also the dose of contrast medium used. These data could be useful in the search and introduction of new or alternative methods of treatment for critically ill children. hydrophila increase the resistance of tilapia to such infection and consequently improve the survival and economic outcome. Lack of preparation, physical health after childbirth, and early postpartum depressive symptoms. The results show that shorter excitation wavelengths and lower reaction temperatures result in high yields of nanodecahedra, while longer excitation wavelengths and higher reaction temperatures result in the formation of nanoprisms. 324 lower tier local authorities in England, classified by their baseline level of deprivation.

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The superficial furrows of the sole were recognized as the most important site of larval entry into the snail organism. Fludarabine was associated with a good response and was well tolerated in patients with follicular lymphoma in phase II trials and this treatment may be associated with less adverse events than treatment with CHVP plus interferon in elderly patients. Consensus scoring: A method for obtaining improved hit rates from docking databases of three-dimensional structures into proteins. Principles of preoperative preparation of patients with diffuse goiter. Likewise, medical applications (apps) have provided educational tools easily accessible to clinicians through their mobile devices. Influence and interactions of multi-factors on the bioavailability of PAHs in compost amended contaminated soils.

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Hematoxylin and eosin and Oil-Red-O staining were used to evaluate the atherosclerotic lesions and lipid accumulation in ApoE mice. 18F-FATPs exhibit higher EF values and more rapid clearance from the liver and lung than 13N-NH3 in normal rats, which led to excellent image quality in a rat model of coronary occlusion. This study sought to identify clinical and manometric characteristics of male fecal incontinence. The membrane-associated trimeric complex VapA-VipC-VapB controls a signal transduction pathway for fungal differentiation. The purpose of the present study is to examine changes of the circadian period in humans during temporal isolation, where the circadian rhythm is free-running. Functional and phenotypic analysis of T-lymphocytes in laryngeal carcinoma. Comparative clinical evaluation of the effectiveness of modified radical mastectomy and organ-preserving therapy in localized breast cancer (pT1-2N0M0). Bone destruction and tumor formation in femur were checked by hematoxylin and eosin staining. Voluntary restriction of physical activity in healthy young subjects caused marked reduction in spectral power in the lowest frequency band which is often used to assess patient prognosis. MRJF4, a novel histone deacetylase inhibitor, induces p21 mediated autophagy in PC3 prostate cancer cells.

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These results may be of benefit in the prevention and/or control of the spread of leptospirosis in humans due to Leptospira-infected rats. The aim of this study was to assess the predictive value of these features for malignancy. Successful aspiration thrombectomy was performed using a 7F multipurpose guiding catheter advanced to the site of obstruction. A major focus in the study of endothermic thermoregulation has been the description of thermoregulatory patterns used by various species and/or populations. In two distantly related acoel taxa, we identify only three distinct classes of Hox gene: an anterior gene, a posterior gene, and a central class gene most similar to genes of Hox classes 4 and 5 in other Bilateria. Diagnosis of multiple sclerosis is based on detection of a disseminated demyelinating inflammatory disorder of the central nervous system with a progressive course and(or) exacerbations. The HRT I was developed for research purposes only and was not used clinically. Variables obtained from the other recording sites did not change with maternal hyperoxygenation.

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Electroencephalographic study on the mechanism of convulsive seizure, especially on the role of the subcortical nuclei. The purpose of the present study was to modify and validate this technique for a more general use in humans. Herein, the authors discuss the current progress toward these goals and the efforts being made to develop a safe and efficacious method of clot removal in the treatment of acute ischemic stroke. Immunoblot analysis using a monoclonal antibody risen against rat lung ECE showed the presence of immunoreactive protein in membrane fraction prepared from both HUVEC and COS-1 cells transfected with human ECE cDNA. Choice of Antiepileptic Drugs in Idiopathic Generalized Epilepsy: UAE Experience. The SRA gene was detected in isolates from cattle, sheep, pigs, dog, reedbuck, hyena and G. Only those positive for metastases were submitted to axillary dissection.

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Prognostic significance of high hyperdiploid and triploid/tetraploid adult acute myeloid leukemia. The aim of this study was to systematically review the reliability and validity of instruments used to screen for major depressive disorder or assess depression symptom severity among persons with HIV in sub-Saharan Africa. The possibility of using this kind of multiple polymorphism of DNA in population genetic investigations at the level of ethnic groups and peoples is discussed, and a conclusion is made about the necessity of searching for the most informative methods of analyzing the data obtained. Experimental occlusion of the middle cerebral artery during arterial hypotension. Therefore, it is crucial to assess the impact of RDs on the general population in what refers to their prevalence, and repercussion on quality of life and function. The data of HB virus infection in eight cities were analysed in order to save test cost and to achieve similar immune effect. HLA-G is a molecule that was first known to confer protection to the fetus from destruction by the immune system of its mother, thus critically contributing to fetal-maternal tolerance. At the time of the study, 47 patients had met the inclusion criteria, with 40 patients being randomised for analysis. We investigated effects of co-culture on proliferation, apoptosis and cytokine release. Dissolved organic carbon and disinfection by-product precursor release from managed peat soils.

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