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Pecalm (Alprazolam)

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Alprazolam, available under the trade name Xanax, is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder, but also in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Pecalm, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Pecalm is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Aderta, Alcalm, Alfix, Alpram, Alprawin, Alprogard, Alprop, Alprowon, Altok, Alzin, Alzotime, Anzilum, Axnil, Balzam, Depten, Destres, Dipra, Dizeral, Emcalm, Exiten, Fluti, Fluzolam, Golprax, Luzarn, Manzolam, Nokzok, Orten, Paxor, Pecalm, Prolam, Pronext, Resolin, Sanprazole, Serxanti, Setex, Sozox, Tenil, Tenlax, Welnorm, Xycalm, Zallpam, Zeprax, Zolorel, Zomark, Zopain

Similar Products:
Cardizem, Skelaxin, Nexium, Vantin, Zanaflex, Claritin, Pamelor, Xalatan, Coreg

Also known as: Alprazolam


Alprazolam is used to relieve symptoms of anxiety, including anxiety caused by depression. It is also used to treat panic disorder in some patients.

Alprazolam is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain alprazolam. It may not be specific to Pecalm. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is used for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the extended-release tablet or tablet whole with a full glass of water. Do not break, crush, or chew it.

If you are using the orally disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not remove the tablets from the bottle until you are ready to take it. Place the tablet immediately on the top of your tongue. It should melt quickly and be swallowed with saliva.

If you are using the oral liquid, measure the dose with a marked measuring spoon, oral syringe, or medicine cup.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For anxiety: For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.25 to 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 4 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For panic disorder: For oral dosage form (extended-release tablets): Adults—At first, 0.5 to 1 milligram (mg) taken in the morning once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.5 mg taken in the morning once a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor.


If you have been prescribed Pecalm for medical reasons, the best way to avoid a Pecalm overdose is to adhere to prescribed orders—closely monitor your dose and the time at which you take your medication. Track your Pecalm consumption in a notebook or on your phone. If you notice that you are taking a higher dose of the drug, taking the drug more often, or you want to consume more of the drug, talk with your doctor immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is very important to protect the orally disintegrating tablets from moisture. Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine.

Detailed Pecalm dosage information

Side effects

The most common side effects associated with Pecalm are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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Genotype was not significant effect in acute and chronic hepatitis B, but HBeAg-positive rate/viral load was higher and liver damage was more severe in severe and end-stage genotype C HBV infection patients. Overall, these results provide important information about the factors implicated in the consideration of cosmetic surgery by women. Most previous reports have shown that the basic mechanism of inguinal hernia involves insufficient collagen strength and metabolism. Imaging left ventricular tissue mechanics and hemodynamics during supine bicycle exercise using a combined tagging and phase-contrast MRI pulse sequence. Although the etiology of the macular hole in the present patient is unclear, tangential traction induced by contraction of the peripapillary membrane, presumed to be an incomplete regression of the Bergmeister papilla, might have been responsible for the formation of the macular hole.

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Adipocytes can also release irisin after exercise, acting as a local adipokine to induce white adipose tissue to take on a brown adipose tissue-like phenotype, suggesting that irisin and its receptor may represent a novel molecular target for the treatment of obesity and obesity-related diabetes. Mesenchymal hamartoma is an uncommon cystic mass of the liver which occurs primarily in children. Inverse association between Lancefield group G Streptococcus colonization and sore throat in slum and nonslum settings in Brazil. We have identified through a series of experiments one important protein factor SMAD4, a co-SMAD critical to the TGF-beta signaling pathway. Influence of blood pressure and blood flow on the activity of the respiratory, vasomotor and cardioregulatory centres. These findings provide useful information to understand the genetic basis of buffalo milk properties and may play a role in accelerating buffalo breeding programs using genomic approaches. Light Responsive Silk Nanofibers: An Optochemical Platform for Environmental Applications. Mesenchymal stem cells from development to postnatal joint homeostasis, aging, and disease.

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C3,4-, C2,3- and C4,6-di-substituted coumarin glucosides synthesized by a click reaction similarly showed a selective FL variation in the presence of silver (I) among a range of metal cations in an aqueous solution. We further analyze a set of 63 mtDNA sequences from blue whales (BWs), concluding that the population grew in the past. Habitual light to moderate alcohol intake (up to 1 drink per day for women and 1 or 2 drinks per day for men) is associated with decreased risks for total mortality, coronary artery disease, diabetes mellitus, congestive heart failure, and stroke. In addition, the importance of the interdisciplinary context to understand, develop and apply these systems as an innovative tool for drug development and improvement is discussed. Neighbourhood development and public health initiatives: who participates?. From Proteomic Analysis to Potential Therapeutic Targets: Functional Profile of Two Lung Cancer Cell Lines, A549 and SW900, Widely Studied in Pre-Clinical Research.

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The vesicles contain protein, mRNA, microRNA, and noncoding RNA and variably some DNA. These agents provide the promise of better tolerability because of their more selective mechanisms of action. We provide a brief overview of the common biomaterials, gelation mechanisms, and microfluidic device designs that are used to generate these microgels, and summarize the most recent works on how they are applied to tissue regeneration. Many plants, including Arabidopsis, exhibit increased freezing tolerance after cold exposure (cold acclimation). These data illustrated that methanotrophs are a group of microorganisms influence the methane consumption in Zoige wetland. In addition, a recently introduced 1D opening algorithm is applied along each selected path. In the presented model a novel search hypothesis is proposed to incorporate angle and amplitude information of an external input vector to decide whether the input matches the long-term memory (LTM) weights of an active node or not, and the embedded NO retrograde mechanism makes the search procedure a closed loop, which improves the stability and convergence speed of the transmitter releasing mechanism in a synapse.

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Denufosol tetrasodium in patients with cystic fibrosis and normal to mildly impaired lung function. Aggregates are compared to the ones of cylindrical brushes, revealing that both form assemblies in the 100 nm range with the charge ratio (molar ratio of porphyrin charges to polyelectrolyte charges) being determining, while the morphology of the resulting network-like assemblies is different for both polyelectrolyte architectures. subtilis ATCC 6051: a GH 43 arabinoxylan arabinofuranohydrolase. Like all RiPPs, lasso peptides are derived from a gene-encoded precursor protein. Here we offer a novel explanation based on a Threshold Public Good Game (PGG) that includes the interaction of individual and group level selection, where individuals can contribute to multiple collective actions, in our model group hunting and group defense. In contrast, in the CasKi cells overexpressing HTRA1, there was an increase in the cell growth rate and in the colonies density compared to cells expressing low levels of HTRA1. No human immunodeficiency virus, hepatitis virus, or parvovirus B19 infections arose during the study. As one of the most effective methods to modify proteins, enzymatic hydrolysis is used widely in the preparation of wheat products in the food industry. Degeneration of peripheral motor axons is a common feature of several debilitating diseases including complicated forms of hereditary spastic paraplegia. Genetic evidence for a contribution of EphA:ephrinA reverse signaling to motor axon guidance.

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Influence of polar solvents on photovoltaic performance of Monascusred dye-sensitized solar cell. Chrysanthemums constitute approximately 30 species of perennial flowering plants, belonging to the family Asteraceae, native to Asia and Northeastern Europe. In all previous reports of SB-mediated gene insertion in somatic cells, the transposase component has been provided by expression of a co-delivered DNA molecule that has the potential for integration into the host cell genome. Author Correction: Associated and Mediating Variables Related to Job Satisfaction among Professionals from Mental Health Teams. Twenty manic patients, twenty schizophrenic patients, and twenty healthy controls performed the word-matching task, in which they were presented with 120 (60 congruent and 60 incongruent) word pairs, they were instructed to discriminate whether each word pair was congruent or incongruent. Degradable Newkome-type and polylysine dendrons functionalized with spermine surface units are used to control the formation of DNA origami structures. Goal of this article is to evaluate the changes over time in the treatment of trauma in general and this specific injury in particular.

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Inheritance of Charcot-Marie-Tooth disease 1A with rare nonrecurrent genomic rearrangement. In conclusion, cytoplasmic viscosity plays a key role in the dynamics of an RBC in a thin pore. We will focus on the alterations of glucose-induced insulin secretion coupling, particularly in ionic channels that have crucial importance in this process. Food pellets as an effective delivery method for a DNA vaccine against infectious pancreatic necrosis virus in rainbow trout (Oncorhynchus mykiss, Walbaum). Using weighted gene co-expression network analysis (WGCNA) we identified 1,147 gene co-expression modules in the BAT from BXH/HXB rats and mapped their module eigengene QTLs. Treatment of refractory and recurrent Clostridium difficile infection.

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Does a genetic variant in FOXO3A predict a milder course of rheumatoid arthritis?. The patients were divided into two intensive follow-up (IF) and usual care (UC) groups. Early Deterioration Indicator: Data- driven approach to detecting deterioration in general ward. The findings of the present study suggest that the overlap between SA, withdrawal and psychotic symptoms often reported in schizophrenia patients, may at least partly reflect a shared genetic vulnerability, instead of merely being either a state marker of - or reaction to - acute psychotic symptoms. Lacrimo-auriculo-dento-digital (LADD) syndrome is an extremely rare disorder which may occur sporadically or inheritably as an autosomal dominant condition. Hypoxia-induced Haem Oxygenase-1 gene expression in neonatal rat cardiac myocytes.

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Toward identifying novel therapeutic options, natural products, notably from medicinal plants used in traditional Chinese medicine (TCM), have been thoroughly investigated. International consortia used these data to compile imputation reference panels that facilitate the imputation of sequence variant genotypes for animals that have been genotyped using dense microarrays. In vitro susceptibility to isavuconazole of Mucorales was evaluated using the CLSI M38-A2 method. Leptin may augment neural compensatory mechanisms in response to upper airway obstruction, minimizing upper airway collapse, and/or mitigating potential OSA severity. Properties of the moving visual world influence cognitive motion perception and the estimation of visual image velocity. Regulation of sporicides under the European Biocidal Products Directive. To investigate the relationship of Chinese medicine syndrome pattern with urinary albumin excretion rate (UAER) and its related factors in patients with diabetic nephropathy (DN). The results are indicative of no impact of methoxyfenozide and flonicamid on the two natural enemies in the field, and both can be considered as potential alternatives to be included in IPM programmes in sweet pepper. Assessment of feline abdominal adipose tissue using computed tomography. The effects on the total artificial hip joint system stresses due to using the proposed SG material femur head (with low stiffness at the outer surface and high stiffness at its core) have been investigated.

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Oral vitamin E supplementation on oxidative stress, vitamin and antioxidant status in intensely exercised horses. Fluid exudation increased incrementally with increasing HMG concentrations. A perceptual weighting model was extended to incorporate the three-source stimuli and used to interpret the data. Culture and personality disorder: a focus on Indigenous Australians. There were no significant differences between the OA and LA groups in terms of clinical characteristics, hospital stay, haemoglobin change, return of bowel activity, complication rates, gestational age at delivery, and birth weight. 13 patients in control group continued their usual dialysis prescriptions and medications, whereas 30g of coix seed per day was added to the usual therapies of 17 patients in coix seed group. Consistent with what has been previously reported, increased risk of renal/hypertension events and cardiac disorders associated with celecoxib therapy mandates caution in patient selection. The major goal of this technology is to employ peptides, full-length proteins, antibodies, and small molecules to simultaneously screen thousands of targets for potential protein-protein interactions or modifications of the proteome. Recently, we developed a rodent model for neural circuitry abnormalities in discrete corticolimbic subregions of subjects with major psychoses.

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Decreased serum undercarboxylated osteocalcin is associated with cognitive impairment in male patients with type 2 diabetes. Lower Extremity Musculoskeletal Injury Risk After Concussion Recovery in High School Athletes. The study of long-term longitudinal databases has provided deeper insight into the clinical significance of HBV DNA suppression, hepatitis B e antigen (HBeAg) seroconversion and hepatitis B surface antigen (HBsAg) seroclearance in chronic hepatitis B. Nanometer-scale oxide thin film transistor with potential for high-density image sensor applications. in 1983, are an attractive option for a successful reconstruction for this defect localisation. In addition, in numerous Asian genomes (more than 300 to date) pre-X or pre-pre-S regions were found just upstream to, respectively, the X and the pre-S1 genes. Strikingly, the regulation by phosphorylation of TERT seems to reveal multiple parallels. Natural as well as synthetic antioxidants are constantly being investigated for their efficiency in combatting the effects of oxidative stress, which appears to be the responsible cause of several diseases, which include cancer, central nervous system disorders, ischaemia-reperfusion disorders, cardiovascular conditions and diabetes. The purpose of this study was to determine whether neurotization of this flap improved sensation of the reconstructed penis.

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Our primary goal was to develop a national standard to consider the needs of rural, urban and telehomecare cardiological services provision ranging from children to adults and the elderly. Associations between individualized goal attainment scores and disability, general health status and global change in condition. Uterine serous carcinoma (USC) is an aggressive variant of Type 2 endometrial carcinoma, which in most cases exhibits, at least focally, a papillary architecture. Endometrial cancer and hyperplasia with complex atypia were considered abnormal. Beta-catenin downregulation is required for adaptive cardiac remodeling. To compare the effectiveness of the administration of inhaled beta-agonists delivered via a metered-dose inhaler (MDI) with spacers--as part of an evidence-based asthma pathway developed to manage acute asthma exacerbations in children at the emergency room level and in inpatient management--against administration via nebulization. To understand the role of SOCS3 in the expression of IL-4, one of the key Th2 cytokines, RBL-2H3 cells (a rat mast cell line) were engineered to express SOCS3 constitutively at a high level or at a lower level using shRNA. The ability of extracellular matrix to provide contextual information and hence control the individual or collective cellular behavior is increasingly being recognized.

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Measurements of choroidal thickness have also enabled new directions in research to study normal and pathological processes within the choroid. Clinical outcome of reconstruction with tissue expanders for patients with cordarone 200 mg 30 tablet breast cancer and mastectomy. Our results could be used to infer the dominant source of noise in neurons from their ISI statistics. Decidualized endometrial stromal cell derived factors promote trophoblast invasion. They also differ notably in the symptom validator of parasuicidal self-harm. We show that genotype imputation of common variants using HapMap haplotypes as a reference is very accurate using either genome-wide SNP data or smaller amounts of data typical in fine-mapping studies. To study the prevalence of circumcision in the United States and to examine the association between circumcision and herpes simplex virus Type 2 (HSV-2) infection. Organocatalytic asymmetric 1,6-additions of beta-ketoesters and glycine imine. Technical difficulties and the difference in the natural history of the disease have excluded rectal cancer from major clinical trials comparing laparoscopic to conventional rectal surgery. Active inflammation of both intestinal wall, and mesentery can be demonstrated accurately.

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However, unexpected differences in the responses of societies to these factors in North America and Mesoamerica, and in Eurasia, became evident after the end of the Neolithic period. Furthermore, the cysteine at V(L)85 of ds-FV57 was mutated to serine to construct ds-FV57(VL85Ser) in order to avoid potential mis-formed disulfide bonds which would alter the affinity of the scFv. Peptides can be labeled with various trivalent radiometals for imaging or targeted radionuclide-therapy applications. Chemotherapy induced neuropathy causes excruciating pain to cancer patients. In the present work, by using oligonucleotide microarray in an in vivo model, we identified an unknown gene BC005512 (abbreviated as BC, official full name: cDNA sequence BC005512), whose expression in mouse liver was specifically induced by seven well-known genotoxins (GTXs), but not by non-genotoxins (NGTXs). This characteristic is likely to be related to the weak binding affinity of the protein for the calcium(II) ions. Patterson-function direct methods for structure determination of organic compounds from powder diffraction data. The number of resonant peaks is directly related to the number of periods. In vivo monitoring of fetoplacental Vegfr2 gene activity in a murine pregnancy model using a Vegfr2-luc reporter gene and bioluminescent imaging. The power of evo-devo to explore evolutionary constraints: experiments with butterfly eyespots.

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After accounting for the independent contribution of biological and psychosocial risk, the interaction of biological and psychosocial risk was significantly associated with parent-rated aggression and marginally related to parent-rated delinquency. ACE activity and mRNA levels were measured in hypothalamus, hippocampus, brainstem, cerebral cortex and striatum tissue extracts. A more detailed examination of the Colombian specimens revealed that it differs from the other morphs so far considered as subspecies. Promoter polymorphism of MRP1 associated with reduced survival in hepatocellular carcinoma. To compare the retinal blood flow velocity using laser speckle flowgraphy (LSFG) and a retinal function imager (RFI) in healthy Japanese subjects. Further development and efficacy testing of symptom cluster interventions is needed.

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Tree rings of Scots pine (Pinus sylvestris L.) as a source of information about past climate in northern Poland. The noninvasive assessment of lung function using imaging is increasingly of interest for the study of lung diseases, including chronic obstructive pulmonary disease (COPD) and asthma. Our experience indicates that patients with adrenal metastases are suitable candidates for laparoscopic adrenalectomy, providing a skilled laparoscopic surgeon is involved in operation. A novel label-free amperometric immunosensor for carcinoembryonic antigen based on Ag nanoparticle decorated infinite coordination polymer fibres. A new tent trap for monitoring the daily activity of Aedes aegypti and Aedes albopictus. Our analysis uses national survey data from the 2010-2016 Gallup Wellbeing-Index. We present a case of rosette forming glioneuronal tumour of the fourth ventricle and highlight the imaging and histological features of this tumour entity. These findings suggest that age-related declines in motor performance may be attributed to a breakdown in the functional organization of large-scale brain networks rather than simply age-related connectivity changes within motor-related networks. Our model may represent a valid platform for preclinical trials on bone-targeted drugs and for the study of the interplay of BC with bone stromal cells. Variables included background and contextual variables, caregiver burden, finding meaning through caregiving (FMTCG), and caregiver physical and mental health.

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Newly added data are stored in a virtual quarantine until an authorized user has validated it. Same-day 4L PEG preparation for afternoon colonoscopy confers better-quality cleansing than prior-day preparation. How early do antibiotics have to be to impact mortality in severe sepsis?. We evaluated the frequency of BP-associated ONJ in Ontario in the cancer population and in those receiving BP for osteoporosis and metabolic bone disease. A qualitative study of an interprofessional narrative-based palliative care course. Coffee and tea consumption are associated with a lower incidence of chronic liver disease in the United States. For the most part, drugs that treat other neuropsychiatric disorders have been examined to treat the people with ASD, unfortunately with little effect on the core symptoms. The study utilized a community-based research and critical race theory approach. An interdisciplinary systems approach to study sperm physiology and evolution.

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Thus, osmolytes can be utilized as therapeutic targets for such diseases. Burn trauma in skeletal muscle results in oxidative stress as assessed by in vivo electron paramagnetic resonance. Deceased heart beating donor and organ transplantation in Saudi Arabia. These studies provide a molecular insight into the regulation of FheproCL1 autocatalysis. We aimed to investigate predictors of insulin uptake, and change in insulin appraisals, among adults with type 2 diabetes mellitus (T2DM) who participated in the Stepping Up cholesterol medication lipitor generic trial. UVB (290-320 nm) interacts directly with DNA, inducing two major photoproducts: cyclobutane-pyrimidine dimers (CPDs) and (6-4) pyrimidine-pyrimidone photoproducts. Chalcone-imidazolone conjugates induce apoptosis through DNA damage pathway by affecting telomeres. Therefore, fat-soluble vitamins should be monitored in these patients.

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