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Protonix (Pantoprazole)

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Protonix is a common medication used to help relieve heartburn also referred to as Gastroesophageal Reflux Disease (GERD). It is usually only taken once per day, but it can increase your risk of bone fractures if taken for a long time.

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Also known as: Pantoprazole


{name} (pantoprazole) is a proton pump inhibitor that decreases the amount of acid produced in the stomach.

{name} is used to treat erosive esophagitis (damage to the esophagus from stomach acid caused by gastroesophageal reflux disease, or GERD) in adults and children who are at least 5 years old. Pantoprazole is usually given for up to 8 weeks at a time while your esophagus heals.

{name} is also used to treat Zollinger-Ellison syndrome and other conditions involving excess stomach acid.


Take Protonix exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Use the lowest dose for the shortest amount of time needed to treat your condition.

Protonix is taken by mouth (oral) or given as an infusion into a vein (injection). A healthcare provider may teach you how to properly use the injection by yourself.

Protonix tablets are taken by mouth, with or without food. The oral granules should be taken 30 minutes before a meal.

Do not crush, chew, or break a Protonix tablet. Swallow the tablet whole.

The oral granules should be sprinkled on 1 teaspoon of applesauce or apple juice and given either by mouth or through a nasogastric (NG) tube.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve.

Call your doctor if your symptoms do not improve or if they get worse while you are using this medicine.

Pantoprazole can cause false results with certain medical tests. Tell the doctor or laboratory staff that you are using this medicine.

Pantoprazole may also affect a drug-screening urine test and you may have false results. Tell the laboratory staff that you use this medicine.

Store this medicine at room temperature away from moisture, heat, and light.

Detailed Protonix dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

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The most common side effects associated with Protonix are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Heartburn can mimic early symptoms of a heart attack. Get emergency medical help if you have chest pain that spreads to your jaw or shoulder and you feel anxious or light-headed.

You should not use Protonix if:

you also take medicine that contains rilpivirine (Edurant, Complera, Juluca, Odefsey); if you had breathing problems, kidney problems, or a severe allergic reaction after taking pantoprazole in the past; or you are allergic to pantoprazole or similar medicines (lansoprazole, omeprazole, Nexium, Prevacid, Prilosec, and others).

Tell your doctor if you have ever had:

low levels of magnesium in your blood; lupus; or osteoporosis or low bone mineral density.

You may be more likely to have a broken bone while using Protonix long-term or more than once per day. Talk with your doctor about ways to keep your bones healthy, especially if you are an adult over 50.

It is not known whether Protonix will affect an unborn baby. Animal studies have shown no harm. Tell your doctor if you are pregnant or plan to become pregnant.

Protonix is secreted in breastmilk, but it is not known whether Protonix will affect a nursing infant. Tell your doctor you are nursing before taking Protonix.

Protonix is not approved for use by anyone younger than 5 years old.

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