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Terramycin (Oxytetracycline)
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Terramycin

Terramycin is used for treating infections caused by certain bacteria. Terramycin is a tetracycline antibiotic. It works by slowing the growth of sensitive bacteria by interfering with the production of proteins needed by the bacteria to grow. Slowing the bacteria's growth allows the body's defense mechanisms to destroy them.

Other names for this medication:
Betacycline, Cotet, Dynoxytet, Ecomycin, Geomicina, Innolyre, Oxyteracin, Oxytetracycline, Tetracin

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Also known as: Oxytetracycline

Description

Terramycin is primarily bacteriostatic and is thought to exert its antimicrobial effect by the inhibition of protein synthesis. Terramycin is active against a wide range of gram-negative and gram-positive organisms.

The drugs in the Terramycin class have closely similar antimicrobial spectra, and cross resistance among them is common. Microorganisms may be considered susceptible if the M.I.C. (minimum inhibitory concentration) is not more than 4.0 mcg/ml and intermediate if the M.I.C. is 4.0 to 12.5 mcg/ml.

Susceptibility plate testing: A Terramycin disc may be used to determine microbial susceptibility to drugs in the Terramycin class. If the Kirby-Bauer method of disc susceptibility testing is used, a 30 mcg Terramycin disc should give a zone of at least 19 mm when tested against a Terramycin-susceptible bacterial strain.

Terramycins are readily absorbed and are bound to plasma proteins in varying degree. They are concentrated by the liver in the bile, and excreted in the urine and feces at high concentrations and in a biologically active form.

Dosage

The usual daily adult dose of Terramycin is 250 mg administered once every 24 hours or 300 mg given in divided doses at 8 to 12 hour intervals. For children above eight years of age the dose is determined by the child's body weight. Terramycin may interact with other drugs. Tell your doctor all medications and supplements you use. During pregnancy, Terramycin should be used only if prescribed. Use during the last half of pregnancy, or during infancy and childhood up to the age of 8 years may cause permanent discoloration of the teeth (yellow-gray-brown). Tell your doctor if you are pregnant or plan to become pregnant before taking Terramycin. This drug passes into breast milk. Consult your doctor before breastfeeding.

Overdose

If you overdose Generic Tetracycline and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Terramycin overdosage: retching, diarrhoea, nausea.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

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The most common side effects associated with Terramycin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

This drug is contraindicated in persons who have shown hypersensitivity to any of the tetracyclines.

As with other antibiotic preparations, use of this drug may result in overgrowth of nonsusceptible organisms, including fungi. If superinfection occurs, the antibiotic should be discontinued and appropriate therapy instituted.

In venereal diseases when coexistent syphilis is suspected, a dark field examination should be done before treatment is started and the blood serology repeated monthly for at least 4 months.

Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage.

In long term therapy, periodic laboratory evaluation of organ systems, including hematopoietic, renal and hepatic studies should be performed.

All infections due to Group A beta-hemolytic streptococci should be treated for at least 10 days.

Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracycline in conjunction with penicillin.

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