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Vitalpha (Calcitriol)
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Vitalpha

Vitalpha is a hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give Vitalpha.

Other names for this medication:
Actical, Admax, Alfacal, Alfacalcirol, Alfacip, Apcical, Arcium, Calbovic, Calcigra, Caldikind, Calgel, Calotec, Caltin, Caltop, Carcal, Citroj, Coecoral, Devita, Duracal, Estovon, Koncal, Minroset, Ostonex, Ostriol, Politrol, Primacal, Qpcal, Riecal, Roical, Rolsical, Solbiocal, Sorvate, Sunmic, Tobalt, Zaxial

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Imdur, Phenergan, Cycrin, Kamagra, Minipress, Hydrea, Furadantin, Daklinza

Also known as: Calcitriol

Description

Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are available in the foods that you eat. Vitamin D is necessary for strong bones and teeth.

Lack of vitamin D may lead to a condition called rickets, especially in children, in which bones and teeth are weak. In adults it may cause a condition called osteomalacia, in which calcium is lost from bones so that they become weak. Your doctor may treat these problems by prescribing vitamin D for you. Vitamin D is also sometimes used to treat other diseases in which calcium is not used properly by the body.

Ergocalciferol is the form of vitamin D used in vitamin supplements.

Some conditions may increase your need for vitamin D. These include:

Alcoholism Intestine diseases Kidney disease Liver disease Overactivity of the parathyroid glands with kidney failure Pancreas disease Surgical removal of stomach

In addition, individuals and breast-fed infants who lack exposure to sunlight, as well as dark-skinned individuals, may be more likely to have a vitamin D deficiency. Increased need for vitamin D should be determined by your health care professional.

Alfacalcidol, calcifediol, calcitriol, and dihydrotachysterol are forms of vitamin D used to treat hypocalcemia (not enough calcium in the blood). Alfacalcidol, calcifediol, and calcitriol are also used to treat certain types of bone disease that may occur with kidney disease in patients who are undergoing kidney dialysis.

Claims that vitamin D is effective for treatment of arthritis and prevention of nearsightedness or nerve problems have not been proven. Some psoriasis patients may benefit from vitamin D supplements; however, controlled studies have not been performed.

Injectable vitamin D is given by or under the supervision of a health care professional. Some strengths of ergocalciferol and all strengths of alfacalcidol, calcifediol, calcitriol, and dihydrotachysterol are available only with your doctor's prescription. Other strengths of ergocalciferol are available without a prescription. However, it may be a good idea to check with your health care professional before taking vitamin D on your own. Taking large amounts over long periods may cause serious unwanted effects.

Dosage

This section provides information on the proper use of a number of products that contain vitamin d and related compounds. It may not be specific to Vitalpha. Please read with care.

For use as a dietary supplement:

Do not take more than the recommended daily amount. Vitamin D is stored in the body, and taking too much over a period of time can cause poisoning and even death.

If you have any questions about this, check with your health care professional.

For individuals taking the oral liquid form of this dietary supplement:

This preparation should be taken by mouth even though it comes in a dropper bottle. This dietary supplement may be dropped directly into the mouth or mixed with cereal, fruit juice, or other food.

While you are taking alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, doxercalciferol or paricalcitol , your health care professional may want you to follow a special diet or take a calcium supplement. Be sure to follow instructions carefully. If you are already taking a calcium supplement or any medicine containing calcium, make sure your health care professional knows.

The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For alfacalcidol To treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For parenteral dosage form (injection): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 12 mcg a week. To treat diseases in which calcium is not used properly by the body: For oral dosage form (capsules): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 0.25 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day.

For calcifediol To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults, teenagers, and children over 10 years of age—At first, 300 to 350 micrograms (mcg) a week, taken in divided doses either once a day or every other day. Your doctor may change your dose if needed. Children 2 to 10 years of age—50 mcg a day. Children up to 2 years of age—20 to 50 mcg a day. To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage forms (capsules and solution): Adults, teenagers, and children—At first, 0.25 micrograms (mcg) a day. Your doctor may change your dose if needed. For parenteral dosage forms (injection): Adults and teenagers—At first, 0.5 mcg injected into a vein three times a week. Your doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For dihydrotachysterol To treat diseases in which calcium is not used properly by the body: For oral dosage forms (capsules, solution, or tablets): Adults and teenagers—At first, 100 micrograms (mcg) to 2.5 milligrams (mg) a day. Your doctor may change your dose if needed. Children—At first, 1 to 5 mg a day. Your doctor may change your dose if needed.

For doxercalciferol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—10 micrograms (mcg) three times weekly at dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For ergocalciferol The amount of vitamin D to meet normal daily recommended intakes will be different for different individuals. The following information includes only the average amounts of vitamin D. To prevent deficiency, the amount taken by mouth is based on normal daily recommended intakes: For oral dosage form (capsules): For the U.S. Adults and teenagers—5 to 10 micrograms (mcg) (200 to 400 Units) per day. Pregnant and breast-feeding females—10 mcg (400 Units) per day. Children 4 to 10 years of age—10 mcg (400 Units) per day. Children birth to 3 years of age—7.5 to 10 mcg (300 to 400 Units) per day. For Canada Adults and teenagers—2.5 to 5 mcg (100 to 200 Units) per day. Pregnant and breast-feeding females—5 to 7.5 mcg (200 to 300 Units) per day. Children 7 to 10 years of age—2.5 to 5 mcg (100 to 200 Units) per day. Children 4 to 6 years of age—5 mcg (200 Units) per day. Children birth to 3 years of age—5 to 10 mcg (200 to 400 Units) per day. To treat deficiency: Adults, teenagers, and children—Treatment dose is determined by prescriber for each individual based on severity of deficiency. To treat diseases in which calcium and phosphate are not used properly by the body: Adults and teenagers—At first, 1000 to 500,000 Units a day. The doctor may change your dose if needed. Children—At first, 1000 to 200,000 Units a day. The doctor may change your dose if needed.

For paricalcitol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—1 to 2 micrograms (mcg) one time per day or 2 to 4 mcg three times a week (not more often than every other day). The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor. For parenteral dosage form (injection): Adults—0.04 to 0.1 micrograms (mcg) per kg no more than every other day during dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Generic Vitalpha and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Vitalpha are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Generic Vitalpha if you are allergic to Generic Vitalpha components. Do not take Generic Vitalpha if you are pregnant, planning to become pregnant, or are breast-feeding. It is not known if this medication appears in breast milk. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Be careful with Generic Vitalpha if you have heart disease, kidney disease or kidney stones, coronary artery disease (hardening of the arteries). Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. It can be dangerous to stop Generic Vitalpha taking suddenly.

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Acute biliary disease: initial CT and follow-up US versus initial US and follow-up CT. Intravenous hyaluronidase in the treatment of patients with cranial injuries. However, the integration of deregulated genes within coherent metabolic pathways is lacking. We analyzed the effect of the lack of OPN in the development of obesity and hepatic steatosis induced by a high-fat diet (HFD) using OPN-KO mice. Oxidative stress produced in response to infection or sterile injury activates the innate immune response. Self-seeding microwell chip for the isolation and characterization of single cells. They are also higher in aggregate surface fractions than in aggregate core fractions and in bulk soil samples than in aggregates. Tissue distribution and effects of fasting and obesity on the ghrelin axis in mice.

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Population-based analysis of the geographic distribution of Ontario ophthalmologists. Our results showed that the cone b-wave amplitude in the ERG is decreased, that there is a progression in this decrease during a follow-up period of 5 years, and that the cone b-wave implicit time is prolonged. Our aim was to evaluate the additional diagnostic value of these markers. The goal of this study was to determine whether development of vascular inward remodeling may depend on genetic factors. This study aims to synthesize microcapsules that are able to target and adsorb to specific proteins (i.e., collagen type IV and fibronectin) through antibody-antigen interactions, while simultaneously suppressing any unspecific binding, a characteristic that is commonly observed in polyelectrolyte microcapsule-protein interactions. Experiences in treating infantile pneumonia by traditional Chinese drugs. Influence of catecholamines on arterial oxygen tension in the anesthetized dog.

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This systematic review describes the current state of the literature on OOPPs, with particular focus on the effectiveness of these programs. LPIN1 rs33997857, rs6744682, and rs6708316 did not associate with type 2 diabetes, obesity, or related quantitative metabolic phenotypes in the Danish population examined. Fatty acid analyses of hepatocytes showed that EGF treatment resulted in a significant decrease in the relative levels of 20:4omega6 (arachidonic acid) and an increase in 18:2omega6 (linoleic acid). The mutation was found to weaken the interaction with DNA and also cause loss of helicity within the 141-144 region. When the same tissue was examined ultrastructurally, the patches were not restricted to synaptic specializations but were also found distributed on perikaryal and dendritic membranes sometimes associated with synapses and sometimes not. Our preliminary findings do not support use of MARS in patients with postoperative hepatic failure and progressive septic multiple organ dysfunction, particularly if the septic focus cannot be eliminated. So far, however, no analytic results for MSE or multivariate MSE have been reported. The enhanced transcriptional activity of the V-val subtype of Epstein-Barr virus nuclear antigen 1 in epithelial cell lines. The International Osteoporosis Foundation developed a Best Practice Framework to provide a quality benchmark. The ultrastructural analysis of the midgut of Cephalotes atratus, C.

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Running-induced muscle injury and myocellular enzyme release in rats. Barbiturate antagonism of isonipecaine convulsions and isonipecaine potentiation of barbiturate depression. More students reported receiving relevant instruction within the pharmacy school curriculum than outside the curriculum. G-CSF has immunomodulatory effects of neutrophilic granulocytes and monocytes/macrophages. The choroid plexus of the rat has been studied in detail by electron microscopy.

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Thus, although the pattern and sites of deposition-related acetylation appear to be highly conserved in H4, the same does not appear to be the case for histone H3. Sedimentation of poliomyelitis virus in the Sharples centrifuge. Influence of ageing on blastogenesis of mouse thymocytes in response to concanavalin A. Pharmacokinetics of ketorolac after intravenous and oral single dose administration in dogs. cruzi, Strongyloides stercoralis, HIV, human T cell lymphotropic virus (HTLV) and syphilis in Latin American immigrants admitted to hospital in Spain. As for the structure of the isolated protein, experimental results support the hypothesis that more globular conformations are sampled, but information at atomic resolution is still lacking. Sulfadimethoxine plus phenylazo-diamino-pyridine hydrochloride in the treatment of urogenital infections.

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This study presents the results of 139 children who sustained a total of 161 such fractures and were admitted to the Royal Hospital for Sick Children, Edinburgh, between January 1983 and December 1992. In our studies we have shown that miRNAs respond to swimming aerobic exercise by 1) decreasing cardiac fibrosis through miRNA-29 increasing and inhibiting collagen, 2) increasing angiogenesis through miRNA-126 by inhibiting negative regulators of the VEGF pathway, and 3) modulating the renin-angiotensin system through the miRNAs-27a/b and -143. Monitoring the clearance of fetal RhD-positive red cells in FMH following RhD immunoglobulin administration. The occupational and operational considerations for the military environment are also discussed. We also aimed to identify factors in both the caregiver and patient that are associated with significant levels of burden. Conserved molecular mechanisms underlying homeostasis of the Golgi complex.

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Beta-cell proliferation in normal and streptozotocin-treated newborn rats: site, dynamics and capacity. Cross-sectional study comparing diagnostic data with a recommended standard. The programs permit assessment of maximum luminance, display function, dynamic range, and contrast. Archaea in and on the Human Body: Health Implications and Future Directions. In this review we provide an overview of TF, describe mouse models used in the evaluation of the role of TF in thrombosis, as well as summarize recent work on TF and APS. Histopathological exam confirmed the diagnosis of a dentigerous cyst. The purpose of this study was to use a large population-based database to define the population that is at risk for cardiac device infections, determine the prevalence of device infections, and study changes in the rates of cardiac device implantation and infection in the past decade. Treatment of bovine pulmonary artery endothelial cells with the calcium ionophore, A23187, stimulates the cell membrane associated protease activity, phospholipase A2 (PLA2) activity, and arachidonic acid (AA) release from the cells.

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Here, we took advantage of its specific expression pattern in Arabidopsis (Arabidopsis thaliana) in a cell-sorting and transcriptomic approach to generate a lateral root-specific cell sorting SKP2B data set that represents the endogenous genetic developmental program. It is shown that the fullerene-exchange reaction from the cyclodextrin cavity to liposomes, to prepare lipid membrane-incorporating fullerenes, occurred above the phase transition temperature (T(m)) of liposomes. Overview: future approaches to renal replacement and regeneration. We measure axial diffusion in binary mixtures, completely embedded in water, by means of nuclear magnetic imaging (magnetic resonance imaging). Highly sensitive how much is clomid cost in nigeria gold nanoparticle-based colorimetric sensing of mercury(II) through simple ligand exchange reaction in aqueous media. The dielectrophoretic methods require only a few micro litres of blood, and should be applicable to the production of small, low-cost automated devices for assessing parasite concentrations with potential applicability to drug sensitivity studies and the diagnosis of malaria. LPS stimulated the release of PGE2, IL-1 and IFN activity in C3H/OuJ macrophages, but not in C3H/HeJ macrophages. Structural characterization and biological fluid interaction of Sol-Gel-derived Mg-substituted biphasic calcium phosphate ceramics.

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Various reporter-encoding IAV were generated to achieve these goals, however, one recurring difficulty was the genetic instability especially of larger reporter genes. The major components were 1,8-cineole, fragranol, fragranyl acetate and terpin-4-ol. Schistosoma japonicum: size of egg granulomas in vaccinated and non-vaccinated hosts as observed in bovines. Psoriasis is a common chronic relapsing, inflammatory, hyperproliferative skin disorder with genetic predisposition. Large-scale prevalence studies are needed to identify the full range of safety and quality problems in developing countries in Southeast Asia. We performed rpoB gene sequencing and multi-locus sequence typing (MLST) on M. Corticosteroid binding globulin: a new target for cortisol-driven obesity. Moving to place: childhood cancer treatment decision making in single-parent and repartnered family structures.

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Measurement of fetal urine production in mild infantile polycystic kidney disease--a case report. Patients with Parkinson disease revealed a significant delay of the N130 component only. Comparative characteristics of conditioned motor reactions on auditory stimuli in man produced on verbal and olfactory reinforcing stimuli. The European Pharmacopeia test did not detect any differences between the products. Thyroidectomy was performed on all 17 patients (8 subtotal, 9 total) through a low transverse collar incision. Quality of life related to oral mucositis of patients undergoing haematopoietic stem cell transplantation and receiving specialised oral care with low-level laser vasotec normal dosage therapy: a prospective observational study. These results support the importance of early-onset DD in parents as a risk factor for psychopathology in their offspring. These results demonstrated that although second-order stimuli maintained responding and caused the rat to check for primary reinforcement, overall response rates were increased when the second-order stimuli were omitted.

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Therapeutic community methods in methadone maintenance (Passages): an open clinical trial. Changes in respiratory resistance to low dose carbachol inhalation and to pneumatic trouser inflation are correlated. The catheter was then used for enteral nutrition and administration of the proximal jejunal effluent. Facile Preparation of a Thiol-Reactive (18)F-Labeling Agent and Synthesis of (18)F-DEG-VS-NT for PET Imaging of a Neurotensin Receptor-Positive Tumor. The study group consisted of 52 patients with advanced (stage IIIB and IV) non-small cell lung cancer. An analysis of the rollover backstroke turn by age-group swimmers. 20-min acupuncture on points E36 intensifies acid production while 40-min procedure inhibits acid production. De novo sequencing of the tryptic peptides used low-energy collisionally-induced dissociation (CID) in an electrospray ionization quadrupole-ToF orthogonal hybrid mass spectrometer (ESI Q-ToF MS/MS). Superiority of one method over another has not been demonstrated consistently from one study to the next.

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Provision of human milk has important implications for the health and outcomes of extremely preterm (EP) infants. A good response was obtained with a recovery of visual acuity of 20/25 on both eyes and an almost complete resolution of the SRDs. No causality assessment approach is perfectly suited for hepatotoxicity from HDS, but the Roussel Uclaf Causality Assessment Method is most used. We found LINE-1 hypomethylation levels between ameloblastoma and KCOT are different. Renal failure was produced zantac 75 mg recall in rats by feeding an adenine-containing diet for 4 weeks, and time-course changes in biochemical parameters, including Ca, Pi, creatinine (Cr), blood urea nitrogen (BUN), parathyroid hormone (PTH), 1,25-dihydroxyvitamin D(3), and N-telopeptide and cross-linked collagen type I (NTx), were monitored once a week during the feeding period. Herein, we report two cases of BMT nephropathy that developed coincident with retinoic acid therapy. Similarly, chicks observed for 7 days exhibited significantly elevated aggression 5 days after injection, after which their pecking decreased to control levels on days 6 and 7. The time course of the effect is within 3-4 hr of elevated PM(2.5).

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Recent data suggest the involvement of mRNA stability in the induction of specific apoptosis pathways. Quantitative export of FGF-2 occurs through an alternative, energy-dependent, non-ER/Golgi pathway. These dynamics are critical for controlling the activity of nitrate reductase, as the formation of polar assemblies potentiates the electron flux through the complex. Significant CoMFA results were obtained when crudely optimized geometries and simple charge schemes were used. Res has a what does tramadol look like 50 mg protective effect on neonatal rat cardiomyocyte lesion induced by hypoxia.

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pB264, a small, mobilizable, temperature sensitive plasmid from Rhodococcus. The relationship between survival after out-of-hospital cardiac arrest and process measures for emergency medical service ambulance team performance. This algorithm is the only one for the cerebellum that does not presume anatomical knowledge of whether the cells are in the molecular layer or the granular layer. We report here the long-term, complete, and functional hematopoietic repopulation of primary and serial recipients with AGM-derived cells. Measurement techniques or instruments are typically evaluated along the dimensions of reliability and validity. In essence, FANCJ deficiency alters the competition between two pathways: MGMT-prosurvival versus MMR-prodeath. Removal of serine at position one, N-acetylation, or replacement of the phenylalanine at position two with alanine resulted in analogues which were inactive in stimulating mesangial cell proliferation or calcium mobilization. In addition, there was a concomitant upregulation of active-caspase-3, which also co-localized with MAL in RGCs. Intracellular and field potential recordings reveal two re-entrant paths for interaction of presubicular and subicular neurons. In this article, I review the principles that are used to analyze costs that are identified in a typical dermatopathology laboratory.

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