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Zanaflex (Tizanidine)

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Zanaflex is a medication that is used to treat muscle spasticity due to spinal cord injury or multiple sclerosis. Effectiveness appears similar to baclofen or diazepam. It is taken by mouth.

Other names for this medication:

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Also known as: Tizanidine


Tizanidine is used to help relax certain muscles in your body. It relieves spasms, cramping, and tightness of the muscles caused by medical problems, such as multiple sclerosis or certain injuries to the spine. Tizanidine does not cure these problems, but it may allow other treatment, such as physical therapy, to be more helpful in improving your condition.

Tizanidine acts on the central nervous system (CNS) to produce its muscle relaxant effects. Its actions on the CNS may also cause some of the medicine's side effects.

This medicine is available only with your doctor's prescription.


You should take it by mouth. It usually is taken two or three times a day. If you want to achieve most effective results do not stop taking Generic Zanaflex suddenly.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include weakness, drowsiness, confusion, slow heart rate, shallow breathing, feeling light-headed, or fainting.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Tizanidine dosage information

Side effects

The most common side effects associated with Zanaflex are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Zanaflex if you are allergic to tizanidine, or if:

you also take the antidepressant fluvoxamine (Luvox); or you also take the antibiotic ciprofloxacin (Cipro).

To make sure Zanaflex is safe for you, tell your doctor if you have ever had:

liver disease; kidney disease; or low blood pressure; or high blood pressure.

It is not known whether Zanaflex will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breastfeed while using tizanidine. Ask your doctor about any risk.

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REHABILITATION OF TERMINAL URAEMIC PATIENTS BY PERIODIC HAEMODIALYSIS. In addition to standard functional and radiological examinations, total lung capacity and residual volume were measured with the plethysmographic and helium dilution technique. All of 26 M-type 12 strains lacked IgA and IgG Fc-receptors, whereas all 32 M-type 22 strains had IgG Fc-receptors and 20 of them also receptors for IgA Fc. New applications of the method involve systems of greater complexity, such as membrane-bound receptors and ribosomes. We here show that E(2) actions on G proteins, PRL production, and cell proliferation were maximally achieved in D2S cells, oppositely or marginally achieved in D2L cells, and absent in V cells. Minimal surgical trauma to both graft and the host bed is important for early revascularization of the graft, and, therefore, also contributes to a more complete incorporation of the graft.

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